FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306319395> ?p ?o ?g. }

• W4306319395 abstract "Abstract Introduction In patients with diabetes mellitus (DM), the presence of myocardial dysfunction in the absence of coronary artery disease, valvular disease and other conventional cardiovascular risk factors has been defined as diabetic cardiomyopathy. Left ventricle concentric hypertrophy and myocardial fibrosis are the structural hallmarks that lead to overt diastolic dysfunction. The impact of DM in imaging features and clinical outcomes of patients with non-ischaemic dilated cardiomyopathy (DCM) has not been completely elucidated yet. Purpose We aim to describe advance imaging and clinical characteristics of DCM's patients with DM, and its potential impact on cardiac morphology and function in comparison to non-diabetic patients. Methods From 2014 to 2021, all patients with DCM were prospectively evaluated in our tertiary care hospital. All patients underwent a transthoracic echocardiogram and 165 patients underwent a 1.5 Tesla scanner cardiac magnetic resonance (CMR) as part of the diagnostic workup. Left ventricle ejection fraction (LVEF), mechanical dyssynchrony, and diastolic function were analyzed according to current guidelines. Late gadolinium enhancement (LGE) was assessed visually and its extent was calculated as the number of affected myocardial segments. Heart failure (HF) hospitalizations, arrhythmic events and mortality were assessed during follow-up. Results The median age of our cohort (n=227) was 61.6 (14.7) years, 66% were male, and DM was present in 57 patients (25.1%). Mean follow-up was 37.6 (33.9) months. Diabetic patients were significantly older, more frequently male, and with more comorbidity. Left bundle branch block was more frequent in patients with DM. The use of SGLT2 inhibitors was higher in diabetic patients (47.4% vs 21.1%; p&lt;0.05). No significant differences were observed regarding other guideline-recommended HF drugs. With regard to imaging features, no significant differences were found in LVEF and global longitudinal strain between the two groups. There was a trend toward a higher left ventricle mass index measured by CMR in diabetic patients (p=0.364). Parameters of mechanical dyssynchrony and diastolic dysfunction were worse in diabetic patients (Table 1). High-risk LGE pattern (defined as the presence of epicardial, transmural or septal plus free-wall LGE) was more frequently observed in the diabetes group (p&lt;0.05). Finally, the diabetic group had a higher incidence of HF hospitalization (45.61% vs 22%, p&lt;0.001) and all-cause mortality (24.6% vs 11.8%, p&lt;0.05), as shown in Figure 1. There was also a trend toward a higher cardiovascular mortality (12.3% vs 6.5%, p=0.164) in this group. Conclusion DM confers a high-risk profile to DCM patients, explained by extracardiac (more comorbidities) and cardiac (more diastolic dysfunction and high-risk LGE pattern) reasons. These patients may benefit from a close monitoring, and new therapies should be developed to improve their prognosis. Funding Acknowledgement Type of funding sources: None." @default.
• W4306319395 created "2022-10-16" @default.
• W4306319395 creator A5015810315 @default.
• W4306319395 creator A5018214378 @default.
• W4306319395 creator A5027067127 @default.
• W4306319395 creator A5040224978 @default.
• W4306319395 creator A5081384249 @default.
• W4306319395 creator A5085128550 @default.
• W4306319395 creator A5088885810 @default.
• W4306319395 creator A5090152322 @default.
• W4306319395 date "2022-10-01" @default.
• W4306319395 modified "2023-10-17" @default.
• W4306319395 title "Impact of diabetes mellitus in non-ischemic dilated cardiomyopathy: focus on diastolic dysfunction" @default.
• W4306319395 doi "https://doi.org/10.1093/eurheartj/ehac544.1689" @default.
• W4306319395 hasPublicationYear "2022" @default.
• W4306319395 type Work @default.
• W4306319395 citedByCount "0" @default.
• W4306319395 crossrefType "journal-article" @default.
• W4306319395 hasAuthorship W4306319395A5015810315 @default.
• W4306319395 hasAuthorship W4306319395A5018214378 @default.
• W4306319395 hasAuthorship W4306319395A5027067127 @default.
• W4306319395 hasAuthorship W4306319395A5040224978 @default.
• W4306319395 hasAuthorship W4306319395A5081384249 @default.
• W4306319395 hasAuthorship W4306319395A5085128550 @default.
• W4306319395 hasAuthorship W4306319395A5088885810 @default.
• W4306319395 hasAuthorship W4306319395A5090152322 @default.
• W4306319395 hasBestOaLocation W43063193951 @default.
• W4306319395 hasConcept C126322002 @default.
• W4306319395 hasConcept C126838900 @default.
• W4306319395 hasConcept C134018914 @default.
• W4306319395 hasConcept C143409427 @default.
• W4306319395 hasConcept C164705383 @default.
• W4306319395 hasConcept C2776008845 @default.
• W4306319395 hasConcept C2776383484 @default.
• W4306319395 hasConcept C2776553924 @default.
• W4306319395 hasConcept C2777473070 @default.
• W4306319395 hasConcept C2778198053 @default.
• W4306319395 hasConcept C2778213512 @default.
• W4306319395 hasConcept C2778797674 @default.
• W4306319395 hasConcept C2778921608 @default.
• W4306319395 hasConcept C500558357 @default.
• W4306319395 hasConcept C555293320 @default.
• W4306319395 hasConcept C57900726 @default.
• W4306319395 hasConcept C71924100 @default.
• W4306319395 hasConcept C78085059 @default.
• W4306319395 hasConcept C84393581 @default.
• W4306319395 hasConceptScore W4306319395C126322002 @default.
• W4306319395 hasConceptScore W4306319395C126838900 @default.
• W4306319395 hasConceptScore W4306319395C134018914 @default.
• W4306319395 hasConceptScore W4306319395C143409427 @default.
• W4306319395 hasConceptScore W4306319395C164705383 @default.
• W4306319395 hasConceptScore W4306319395C2776008845 @default.
• W4306319395 hasConceptScore W4306319395C2776383484 @default.
• W4306319395 hasConceptScore W4306319395C2776553924 @default.
• W4306319395 hasConceptScore W4306319395C2777473070 @default.
• W4306319395 hasConceptScore W4306319395C2778198053 @default.
• W4306319395 hasConceptScore W4306319395C2778213512 @default.
• W4306319395 hasConceptScore W4306319395C2778797674 @default.
• W4306319395 hasConceptScore W4306319395C2778921608 @default.
• W4306319395 hasConceptScore W4306319395C500558357 @default.
• W4306319395 hasConceptScore W4306319395C555293320 @default.
• W4306319395 hasConceptScore W4306319395C57900726 @default.
• W4306319395 hasConceptScore W4306319395C71924100 @default.
• W4306319395 hasConceptScore W4306319395C78085059 @default.
• W4306319395 hasConceptScore W4306319395C84393581 @default.
• W4306319395 hasIssue "Supplement_2" @default.
• W4306319395 hasLocation W43063193951 @default.
• W4306319395 hasOpenAccess W4306319395 @default.
• W4306319395 hasPrimaryLocation W43063193951 @default.
• W4306319395 hasRelatedWork W1965748328 @default.
• W4306319395 hasRelatedWork W1981569396 @default.
• W4306319395 hasRelatedWork W2152500376 @default.
• W4306319395 hasRelatedWork W2347245660 @default.
• W4306319395 hasRelatedWork W2362265450 @default.
• W4306319395 hasRelatedWork W2388618798 @default.
• W4306319395 hasRelatedWork W2390973779 @default.
• W4306319395 hasRelatedWork W2404087378 @default.
• W4306319395 hasRelatedWork W2999204693 @default.
• W4306319395 hasRelatedWork W3035006171 @default.
• W4306319395 hasVolume "43" @default.
• W4306319395 isParatext "false" @default.
• W4306319395 isRetracted "false" @default.
• W4306319395 workType "article" @default.