FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306319700> ?p ?o ?g. }

• W4306319700 abstract "Abstract Chemotherapy (CTX)-induced neuropathy [CIPN] limits the maximal applicable dose. Static compression for prevention of CIPN is recommended by guidelines. The postulated underlying effect of reduced microvascular perfusion (MP), however, contradicts current knowledge of elegant in vivo studies. We, thus tested the hypothesis of increased MP combined with reduction of aerobic metabolism in response to pressure-adjusted static compression (PSC) in CTX-induced endothelial damage (CIED). Metabolic oxygen demand (dh), tissue oxygenation (StO2), oxygen supply (O2h) and microvascular perfusion (th) were measured with quantitative time-resolved near infra-red spectroscopy (NIRS) and temperature with thermography on upper extremities following standard procedures in healthy volunteers (n=12, 6 female; age 22±2), peripheral arterial disease patients (n=17, PAD; 75% male, age 68±9 years, 42%, positive controls) and CTX (n=22) with and without clinical CIPN (n=11 each, 46% male; age 64±11 years). Endothelial microvascular function was quantified during post-ischaemic reactive hyperaemia (PIRH). Resting muscle metabolism was quantified by dh during minute 1 of arterial occlusion. Perfusion was quantified by th during venous occlusion. PSC was applied with commercially available compression products and patented palmar pads for up to 90 minutes under standardised and controlled conditions. PSC induces instant and constant fall of temperature (−4.8±0.8°C, p&lt;0.05) and oxygen demand (−3.4±5.2μM, p&lt;0.05). PSC lead to further reduction of tissue metabolism (O2h: −27±38%, dh: −27±38.2%, PIRH-AUC: −20±27%, p&lt;0,05 each compared to without PSC). Oxygen supply increased time-dependently (O2h: 3.0±1.3 μM, p&lt;0.001) as consequence of locally increased perfusion (19±45%, p&lt;0.05) with subsequent rise of tissue oxygenation (StO2: 9.1±4.2, p&lt;0.01) that continued beyond the PSC-duration, indicating a rather metabolic mechanism. This effect is accompanied by a significant similar, albeit lesser reaction on the control hand (p&lt;0.05). PIRH was reduced in controls in response to PSC as a sign for reduced metabolism. In PAD, reaction to PSC was less pronounced and non-significant, reflecting effects of endothelial dysfunction. Patients with CTX with CIPN showed significant endothelial dysfunction compared to controls (StO2 downslope −7±2%, T95 (s) 13±5, PIRH-AUC 9±6, p&lt;0.05 each) and to CTX without CIPN (p&lt;0.05 each), like PAD. For the first time, CIED as result of CTX comparable to atherosclerotic disease is shown. In contrast to previous assumptions of clinicians propagating compression therapy for prevention of CIPN, the results presented prove that not constriction of the products, but rather a combination of increased local perfusion and oxygen delivery in combination with mechanical effects on the low pressure system and reduced metabolism is induced by PSC. These findings open the field for well-designed RCTs to develop novel treatment options for CIPN targeting CIED. Funding Acknowledgement Type of funding sources: Private company. Main funding source(s): MEDIACC GmbH" @default.
• W4306319700 created "2022-10-16" @default.
• W4306319700 creator A5014363876 @default.
• W4306319700 creator A5031196074 @default.
• W4306319700 creator A5045460955 @default.
• W4306319700 creator A5046553249 @default.
• W4306319700 creator A5056712955 @default.
• W4306319700 creator A5059280189 @default.
• W4306319700 creator A5059889570 @default.
• W4306319700 creator A5075914819 @default.
• W4306319700 creator A5082295104 @default.
• W4306319700 creator A5089221535 @default.
• W4306319700 date "2022-10-01" @default.
• W4306319700 modified "2023-10-01" @default.
• W4306319700 title "Reduction of aerobic metabolism and increased microvascular perfusion during pressure-adjusted static compression as underlying mechanism with potential of preventing chemotherapy-induced neuropathy" @default.
• W4306319700 doi "https://doi.org/10.1093/eurheartj/ehac544.1957" @default.
• W4306319700 hasPublicationYear "2022" @default.
• W4306319700 type Work @default.
• W4306319700 citedByCount "0" @default.
• W4306319700 crossrefType "journal-article" @default.
• W4306319700 hasAuthorship W4306319700A5014363876 @default.
• W4306319700 hasAuthorship W4306319700A5031196074 @default.
• W4306319700 hasAuthorship W4306319700A5045460955 @default.
• W4306319700 hasAuthorship W4306319700A5046553249 @default.
• W4306319700 hasAuthorship W4306319700A5056712955 @default.
• W4306319700 hasAuthorship W4306319700A5059280189 @default.
• W4306319700 hasAuthorship W4306319700A5059889570 @default.
• W4306319700 hasAuthorship W4306319700A5075914819 @default.
• W4306319700 hasAuthorship W4306319700A5082295104 @default.
• W4306319700 hasAuthorship W4306319700A5089221535 @default.
• W4306319700 hasBestOaLocation W43063197001 @default.
• W4306319700 hasConcept C126322002 @default.
• W4306319700 hasConcept C126894567 @default.
• W4306319700 hasConcept C134018914 @default.
• W4306319700 hasConcept C146957229 @default.
• W4306319700 hasConcept C158846371 @default.
• W4306319700 hasConcept C164705383 @default.
• W4306319700 hasConcept C2777691872 @default.
• W4306319700 hasConcept C3019128504 @default.
• W4306319700 hasConcept C42219234 @default.
• W4306319700 hasConcept C70289976 @default.
• W4306319700 hasConcept C71924100 @default.
• W4306319700 hasConceptScore W4306319700C126322002 @default.
• W4306319700 hasConceptScore W4306319700C126894567 @default.
• W4306319700 hasConceptScore W4306319700C134018914 @default.
• W4306319700 hasConceptScore W4306319700C146957229 @default.
• W4306319700 hasConceptScore W4306319700C158846371 @default.
• W4306319700 hasConceptScore W4306319700C164705383 @default.
• W4306319700 hasConceptScore W4306319700C2777691872 @default.
• W4306319700 hasConceptScore W4306319700C3019128504 @default.
• W4306319700 hasConceptScore W4306319700C42219234 @default.
• W4306319700 hasConceptScore W4306319700C70289976 @default.
• W4306319700 hasConceptScore W4306319700C71924100 @default.
• W4306319700 hasIssue "Supplement_2" @default.
• W4306319700 hasLocation W43063197001 @default.
• W4306319700 hasOpenAccess W4306319700 @default.
• W4306319700 hasPrimaryLocation W43063197001 @default.
• W4306319700 hasRelatedWork W1593992073 @default.
• W4306319700 hasRelatedWork W1970011649 @default.
• W4306319700 hasRelatedWork W1977083740 @default.
• W4306319700 hasRelatedWork W1984140182 @default.
• W4306319700 hasRelatedWork W1986318255 @default.
• W4306319700 hasRelatedWork W1993259366 @default.
• W4306319700 hasRelatedWork W2049007930 @default.
• W4306319700 hasRelatedWork W2067569137 @default.
• W4306319700 hasRelatedWork W2078862509 @default.
• W4306319700 hasRelatedWork W2401227442 @default.
• W4306319700 hasVolume "43" @default.
• W4306319700 isParatext "false" @default.
• W4306319700 isRetracted "false" @default.
• W4306319700 workType "article" @default.