FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306320175> ?p ?o ?g. }

• W4306320175 abstract "Abstract Background We previously observed that: 1) physical activity (PA) decreases stress-related neural activity (SNA) in a dose-dependent manner and 2) resting SNA predicts incident heart failure (HF). Thus, we hypothesize that PA may decrease the risk of incident HF in part through its beneficial effect on SNA. Methods Self-reported PA data were acquired from Partners Biobank participants. Metabolic equivalent of task-minutes per week (MET*minutes/week) were calculated and participants were categorized according to their adherence to current PA recommendations (&lt;500 and ≥500 MET-min/wk). In a subset with clinically indicated 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) imaging (n=744), SNA was measured as a ratio of amygdalar to ventromedial prefrontal cortical activity. Subsequent HF and baseline CVD risk factor data were obtained using International Classification of Diseases Codes. Kaplan-Meier and Cox regression analyses were used to evaluate the relationship between PA vs HF risk. Mediation analysis was used to test whether PA's impact on SNA significantly mediated the association between PA and HF. Results Among 50,363 participants (median age 59 years [IQR 42, 70], 40% male), 13,850 (11.6%) were diagnosed with HF over a median period of 3.1 years. PA within recommendations was associated with lower risk of subsequent HF (hazard ratio (HR) [95% confidence interval (CI)]: 0.849 [0.760, 0.948], p=0.004, Figure 1) in a model adjusted for CVD risk factors and history of myocardial infarction. As noted previously, higher SNA associated with higher risk of subsequent HF (HR [95% CI]: 1.34 [1.08, 1.66], p=0.007); and PA within guideline recommendations (vs.below) associated with lower SNA (Zscore ± SD: −0.14±0.92 vs 0.02±1, p=0.037). Moreover, mediation analysis shows that exercise reduces HF risk in part via reductions in SNA, accounting for 9% of the total relationship between exercise and HF risk (p&lt;0.05, Figure 2). Conclusion PA associates with reductions in: A) stress-associated neural activity and B) subsequent HF risk. Moreover, the mechanism by which PA reduces HF risk may involve salutary effects on stress-related neural pathways. Funding Acknowledgement Type of funding sources: None." @default.
• W4306320175 created "2022-10-16" @default.
• W4306320175 creator A5020779219 @default.
• W4306320175 creator A5024067795 @default.
• W4306320175 creator A5054047716 @default.
• W4306320175 creator A5072752504 @default.
• W4306320175 creator A5074053599 @default.
• W4306320175 creator A5085825612 @default.
• W4306320175 date "2022-10-01" @default.
• W4306320175 modified "2023-09-26" @default.
• W4306320175 title "Stress related neural activity: potential mechanism contributing to benefit of physical activity on heart failure incidence" @default.
• W4306320175 doi "https://doi.org/10.1093/eurheartj/ehac544.2439" @default.
• W4306320175 hasPublicationYear "2022" @default.
• W4306320175 type Work @default.
• W4306320175 citedByCount "0" @default.
• W4306320175 crossrefType "journal-article" @default.
• W4306320175 hasAuthorship W4306320175A5020779219 @default.
• W4306320175 hasAuthorship W4306320175A5024067795 @default.
• W4306320175 hasAuthorship W4306320175A5054047716 @default.
• W4306320175 hasAuthorship W4306320175A5072752504 @default.
• W4306320175 hasAuthorship W4306320175A5074053599 @default.
• W4306320175 hasAuthorship W4306320175A5085825612 @default.
• W4306320175 hasBestOaLocation W43063201751 @default.
• W4306320175 hasConcept C120665830 @default.
• W4306320175 hasConcept C121332964 @default.
• W4306320175 hasConcept C126322002 @default.
• W4306320175 hasConcept C164705383 @default.
• W4306320175 hasConcept C1862650 @default.
• W4306320175 hasConcept C190512316 @default.
• W4306320175 hasConcept C207103383 @default.
• W4306320175 hasConcept C2778198053 @default.
• W4306320175 hasConcept C3020255362 @default.
• W4306320175 hasConcept C44249647 @default.
• W4306320175 hasConcept C500558357 @default.
• W4306320175 hasConcept C50382708 @default.
• W4306320175 hasConcept C61511704 @default.
• W4306320175 hasConcept C71924100 @default.
• W4306320175 hasConcept C78085059 @default.
• W4306320175 hasConceptScore W4306320175C120665830 @default.
• W4306320175 hasConceptScore W4306320175C121332964 @default.
• W4306320175 hasConceptScore W4306320175C126322002 @default.
• W4306320175 hasConceptScore W4306320175C164705383 @default.
• W4306320175 hasConceptScore W4306320175C1862650 @default.
• W4306320175 hasConceptScore W4306320175C190512316 @default.
• W4306320175 hasConceptScore W4306320175C207103383 @default.
• W4306320175 hasConceptScore W4306320175C2778198053 @default.
• W4306320175 hasConceptScore W4306320175C3020255362 @default.
• W4306320175 hasConceptScore W4306320175C44249647 @default.
• W4306320175 hasConceptScore W4306320175C500558357 @default.
• W4306320175 hasConceptScore W4306320175C50382708 @default.
• W4306320175 hasConceptScore W4306320175C61511704 @default.
• W4306320175 hasConceptScore W4306320175C71924100 @default.
• W4306320175 hasConceptScore W4306320175C78085059 @default.
• W4306320175 hasIssue "Supplement_2" @default.
• W4306320175 hasLocation W43063201751 @default.
• W4306320175 hasOpenAccess W4306320175 @default.
• W4306320175 hasPrimaryLocation W43063201751 @default.
• W4306320175 hasRelatedWork W2045987832 @default.
• W4306320175 hasRelatedWork W2063369692 @default.
• W4306320175 hasRelatedWork W2098118216 @default.
• W4306320175 hasRelatedWork W2155913505 @default.
• W4306320175 hasRelatedWork W2779222010 @default.
• W4306320175 hasRelatedWork W2803714001 @default.
• W4306320175 hasRelatedWork W2921981527 @default.
• W4306320175 hasRelatedWork W2999308310 @default.
• W4306320175 hasRelatedWork W3095613549 @default.
• W4306320175 hasRelatedWork W2035069710 @default.
• W4306320175 hasVolume "43" @default.
• W4306320175 isParatext "false" @default.
• W4306320175 isRetracted "false" @default.
• W4306320175 workType "article" @default.