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- W4306353463 endingPage "D69" @default.
- W4306353463 startingPage "D57" @default.
- W4306353463 abstract "Chromatin loops (or chromatin interactions) are important elements of chromatin structures. Disruption of chromatin loops is associated with many diseases, such as cancer and polydactyly. A few methods, including ChIA-PET, HiChIP and PLAC-Seq, have been proposed to detect high-resolution, specific protein-mediated chromatin loops. With rapid progress in 3D genomic research, ChIA-PET, HiChIP and PLAC-Seq datasets continue to accumulate, and effective collection and processing for these datasets are urgently needed. Here, we developed a comprehensive, multispecies and specific protein-mediated chromatin loop database (ChromLoops, https://3dgenomics.hzau.edu.cn/chromloops), which integrated 1030 ChIA-PET, HiChIP and PLAC-Seq datasets from 13 species, and documented 1 491 416 813 high-quality chromatin loops. We annotated genes and regions overlapping with chromatin loop anchors with rich functional annotations, such as regulatory elements (enhancers, super-enhancers and silencers), variations (common SNPs, somatic SNPs and eQTLs), and transcription factor binding sites. Moreover, we identified genes with high-frequency chromatin interactions in the collected species. In particular, we identified genes with high-frequency interactions in cancer samples. We hope that ChromLoops will provide a new platform for studying chromatin interaction regulation in relation to biological processes and disease." @default.
- W4306353463 created "2022-10-16" @default.
- W4306353463 creator A5008485039 @default.
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- W4306353463 creator A5088022479 @default.
- W4306353463 date "2022-10-16" @default.
- W4306353463 modified "2023-10-18" @default.
- W4306353463 title "ChromLoops: a comprehensive database for specific protein-mediated chromatin loops in diverse organisms" @default.
- W4306353463 cites W1980383179 @default.
- W4306353463 cites W1993440360 @default.
- W4306353463 cites W1999368908 @default.
- W4306353463 cites W2000798782 @default.
- W4306353463 cites W2010846728 @default.
- W4306353463 cites W2011463791 @default.
- W4306353463 cites W2018838463 @default.
- W4306353463 cites W2033201031 @default.
- W4306353463 cites W2043398720 @default.
- W4306353463 cites W2048263136 @default.
- W4306353463 cites W2090037139 @default.
- W4306353463 cites W2091417752 @default.
- W4306353463 cites W2101600343 @default.
- W4306353463 cites W2102619694 @default.
- W4306353463 cites W2118258530 @default.
- W4306353463 cites W2121284504 @default.
- W4306353463 cites W2121906867 @default.
- W4306353463 cites W2122732537 @default.
- W4306353463 cites W2142433690 @default.
- W4306353463 cites W2145144631 @default.
- W4306353463 cites W2154726187 @default.
- W4306353463 cites W2158485828 @default.
- W4306353463 cites W2176574121 @default.
- W4306353463 cites W2183091920 @default.
- W4306353463 cites W2195190137 @default.
- W4306353463 cites W2195359644 @default.
- W4306353463 cites W2316537321 @default.
- W4306353463 cites W2338408645 @default.
- W4306353463 cites W2507445921 @default.
- W4306353463 cites W2537679995 @default.
- W4306353463 cites W2553838260 @default.
- W4306353463 cites W2557097554 @default.
- W4306353463 cites W2606675097 @default.
- W4306353463 cites W2614144400 @default.
- W4306353463 cites W2750857187 @default.
- W4306353463 cites W2760366406 @default.
- W4306353463 cites W2763836527 @default.
- W4306353463 cites W2770300814 @default.
- W4306353463 cites W2774297138 @default.
- W4306353463 cites W2792944991 @default.
- W4306353463 cites W2890965399 @default.
- W4306353463 cites W2896719374 @default.
- W4306353463 cites W2898789672 @default.
- W4306353463 cites W2901303766 @default.
- W4306353463 cites W2905183150 @default.
- W4306353463 cites W2910305771 @default.
- W4306353463 cites W2914398292 @default.
- W4306353463 cites W2946098668 @default.
- W4306353463 cites W2951856336 @default.
- W4306353463 cites W2952947531 @default.
- W4306353463 cites W2955816935 @default.
- W4306353463 cites W2963347990 @default.
- W4306353463 cites W2964674548 @default.
- W4306353463 cites W2982376737 @default.
- W4306353463 cites W2983759518 @default.
- W4306353463 cites W2988126442 @default.
- W4306353463 cites W2989837622 @default.
- W4306353463 cites W2990435446 @default.
- W4306353463 cites W2993022331 @default.
- W4306353463 cites W3007150393 @default.
- W4306353463 cites W3008725968 @default.
- W4306353463 cites W3008828407 @default.
- W4306353463 cites W3020614442 @default.
- W4306353463 cites W3046151504 @default.
- W4306353463 cites W3092353457 @default.
- W4306353463 cites W3094523844 @default.
- W4306353463 cites W3094642951 @default.
- W4306353463 cites W3096002368 @default.
- W4306353463 cites W3108737349 @default.
- W4306353463 cites W3109279595 @default.
- W4306353463 cites W3177078124 @default.
- W4306353463 cites W3201305288 @default.
- W4306353463 cites W3201334827 @default.
- W4306353463 cites W3205605155 @default.
- W4306353463 cites W3207672631 @default.
- W4306353463 cites W3209761205 @default.
- W4306353463 cites W3212334377 @default.
- W4306353463 cites W3212477617 @default.
- W4306353463 cites W3215804303 @default.
- W4306353463 cites W3216065158 @default.
- W4306353463 cites W4220938426 @default.
- W4306353463 cites W4221102522 @default.
- W4306353463 cites W4281976431 @default.
- W4306353463 cites W4282023856 @default.