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- W4306362009 abstract "The phosphoinositide-3-kinase (PI3K) pathway is a highly conserved intracellular signaling pathway involving numerous key effectors which, in response to diverse extracellular stimuli, modulate the phenotype and function of most mammalian cell types in a pleiotropic manner. PI3K signaling plays a critical role in the development, activation, and differentiation of lymphocytes. In particular, the PI3Kδ and PI3Kγ isoforms have been shown to carry out essential, non-redundant roles in T cells, and therefore, tight regulation of the PI3K pathway is important to maintain the balance between immune tolerance and inflammation. Recent and ongoing efforts to manipulate the biology of T helper cell subsets in the treatment of autoimmune conditions, inflammatory disorders, as well as cancer have shown promising results, and targeting the PI3K pathway may be beneficial in these contexts. However, more insight as to the precise function of individual PI3K isoforms in pathogenic and protective immune cell subsets is still required, and how exactly PI3K signaling is regulated and integrated with classical immune pathways. This chapter provides an overview of the role of PI3K isoforms in the differentiation and function of T helper cell subsets, within the broader context of targeting this pathway to potentially alleviate immunopathology." @default.
- W4306362009 created "2022-10-17" @default.
- W4306362009 creator A5024088150 @default.
- W4306362009 creator A5054122736 @default.
- W4306362009 creator A5060630033 @default.
- W4306362009 date "2022-01-01" @default.
- W4306362009 modified "2023-10-17" @default.
- W4306362009 title "Control of CD4+ T Cell Differentiation and Function by PI3K Isoforms" @default.
- W4306362009 cites W1486346820 @default.
- W4306362009 cites W1552927675 @default.
- W4306362009 cites W1554976296 @default.
- W4306362009 cites W1590328537 @default.
- W4306362009 cites W1707619336 @default.
- W4306362009 cites W1893336375 @default.
- W4306362009 cites W1917589835 @default.
- W4306362009 cites W1944753949 @default.
- W4306362009 cites W19457734 @default.
- W4306362009 cites W1965759657 @default.
- W4306362009 cites W1977070803 @default.
- W4306362009 cites W1977319855 @default.
- W4306362009 cites W197802193 @default.
- W4306362009 cites W1981904703 @default.
- W4306362009 cites W1984683131 @default.
- W4306362009 cites W1988224683 @default.
- W4306362009 cites W1999553166 @default.
- W4306362009 cites W2008844540 @default.
- W4306362009 cites W2009649694 @default.
- W4306362009 cites W2010038061 @default.
- W4306362009 cites W2012228539 @default.
- W4306362009 cites W2014012091 @default.
- W4306362009 cites W2014219207 @default.
- W4306362009 cites W2017987372 @default.
- W4306362009 cites W2026602389 @default.
- W4306362009 cites W2028549997 @default.
- W4306362009 cites W2028684481 @default.
- W4306362009 cites W2034623756 @default.
- W4306362009 cites W2034691869 @default.
- W4306362009 cites W2035216470 @default.
- W4306362009 cites W2035601867 @default.
- W4306362009 cites W2055630249 @default.
- W4306362009 cites W2056721231 @default.
- W4306362009 cites W2057370954 @default.
- W4306362009 cites W2057781689 @default.
- W4306362009 cites W2058089640 @default.
- W4306362009 cites W2059423024 @default.
- W4306362009 cites W2059724105 @default.
- W4306362009 cites W2066740231 @default.
- W4306362009 cites W2070085523 @default.
- W4306362009 cites W2070361307 @default.
- W4306362009 cites W2078728575 @default.
- W4306362009 cites W2081689799 @default.
- W4306362009 cites W2085678099 @default.
- W4306362009 cites W2095434093 @default.
- W4306362009 cites W2096264324 @default.
- W4306362009 cites W2097863684 @default.
- W4306362009 cites W2100323431 @default.
- W4306362009 cites W2103228630 @default.
- W4306362009 cites W2103470187 @default.
- W4306362009 cites W2116879609 @default.
- W4306362009 cites W2124647461 @default.
- W4306362009 cites W2134053452 @default.
- W4306362009 cites W2142635339 @default.
- W4306362009 cites W2143344012 @default.
- W4306362009 cites W2146734285 @default.
- W4306362009 cites W2150026213 @default.
- W4306362009 cites W2155759076 @default.
- W4306362009 cites W2158224546 @default.
- W4306362009 cites W2164349125 @default.
- W4306362009 cites W2166456730 @default.
- W4306362009 cites W2169511301 @default.
- W4306362009 cites W2170938416 @default.
- W4306362009 cites W2171960842 @default.
- W4306362009 cites W2172712090 @default.
- W4306362009 cites W2213308312 @default.
- W4306362009 cites W2269911941 @default.
- W4306362009 cites W2286851210 @default.
- W4306362009 cites W2290724983 @default.
- W4306362009 cites W2397769881 @default.
- W4306362009 cites W2398183597 @default.
- W4306362009 cites W2489914332 @default.
- W4306362009 cites W2512972788 @default.
- W4306362009 cites W2523989131 @default.
- W4306362009 cites W2527404829 @default.
- W4306362009 cites W2558901993 @default.
- W4306362009 cites W2573719758 @default.
- W4306362009 cites W2587740521 @default.
- W4306362009 cites W2593250177 @default.
- W4306362009 cites W2602063615 @default.
- W4306362009 cites W2607508743 @default.
- W4306362009 cites W2608274564 @default.
- W4306362009 cites W2610283731 @default.
- W4306362009 cites W2735908057 @default.
- W4306362009 cites W2744377419 @default.
- W4306362009 cites W2761652334 @default.
- W4306362009 cites W2761829407 @default.
- W4306362009 cites W2762715294 @default.
- W4306362009 cites W2777469091 @default.
- W4306362009 cites W2783487840 @default.