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- W4306362017 abstract "This chapter is an introduction to phosphoinositide 3-kinases (PI3K), with class I PI3Ks as the central focus. First, the various PI3K isoforms in class I are presented with emphasis on their overall structure, subunits, subunit constitutive domains, domain-domain interactions, and functional relevance. This structural analysis is followed by a comprehensive history of seminal investigations into PI3K activity. Next, we highlight the divergent roles of the isoforms: PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ. This section details signaling pathways in which these PI3K isoforms are involved, including the key upstream regulators of PI3K activity and some downstream cellular effects. Nodes of the PI3K pathway are also presented. Inhibitors of some isoforms are discussed to give an overview of the basis of some immunotherapies that are being used to target cell signaling. Finally, the chapter ends with a discussion of the dysregulation of PI3Ks in diseases including APDS, asthma, arthritis, and oncogenic mutations." @default.
- W4306362017 created "2022-10-17" @default.
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- W4306362017 creator A5067086182 @default.
- W4306362017 creator A5090884597 @default.
- W4306362017 date "2022-01-01" @default.
- W4306362017 modified "2023-09-23" @default.
- W4306362017 title "Class I PI3K Biology" @default.
- W4306362017 cites W10482017 @default.
- W4306362017 cites W133456552 @default.
- W4306362017 cites W1481756857 @default.
- W4306362017 cites W1492329260 @default.
- W4306362017 cites W1496974366 @default.
- W4306362017 cites W1501383613 @default.
- W4306362017 cites W1507160997 @default.
- W4306362017 cites W1510385947 @default.
- W4306362017 cites W1524333424 @default.
- W4306362017 cites W1524405192 @default.
- W4306362017 cites W1525343967 @default.
- W4306362017 cites W1529396499 @default.
- W4306362017 cites W1529636865 @default.
- W4306362017 cites W1538845089 @default.
- W4306362017 cites W1541596409 @default.
- W4306362017 cites W1542778840 @default.
- W4306362017 cites W1545503281 @default.
- W4306362017 cites W1547466369 @default.
- W4306362017 cites W1552727140 @default.
- W4306362017 cites W1553733060 @default.
- W4306362017 cites W1554485696 @default.
- W4306362017 cites W1555536872 @default.
- W4306362017 cites W1555947589 @default.
- W4306362017 cites W1559597555 @default.
- W4306362017 cites W1570524896 @default.
- W4306362017 cites W1571670108 @default.
- W4306362017 cites W1590182320 @default.
- W4306362017 cites W1599961357 @default.
- W4306362017 cites W1668086213 @default.
- W4306362017 cites W1689754237 @default.
- W4306362017 cites W1726025741 @default.
- W4306362017 cites W1789958833 @default.
- W4306362017 cites W1818313483 @default.
- W4306362017 cites W1833591189 @default.
- W4306362017 cites W1838131144 @default.
- W4306362017 cites W1867136150 @default.
- W4306362017 cites W1875037981 @default.
- W4306362017 cites W1876455218 @default.
- W4306362017 cites W1887846854 @default.
- W4306362017 cites W1908612571 @default.
- W4306362017 cites W1920523949 @default.
- W4306362017 cites W1920844816 @default.
- W4306362017 cites W1923816168 @default.
- W4306362017 cites W1927626441 @default.
- W4306362017 cites W1930693802 @default.
- W4306362017 cites W1931843124 @default.
- W4306362017 cites W1964822816 @default.
- W4306362017 cites W1964841658 @default.
- W4306362017 cites W1966831459 @default.
- W4306362017 cites W1968186500 @default.
- W4306362017 cites W1969292035 @default.
- W4306362017 cites W1969974933 @default.
- W4306362017 cites W1970575648 @default.
- W4306362017 cites W1971333358 @default.
- W4306362017 cites W1972285445 @default.
- W4306362017 cites W1972974751 @default.
- W4306362017 cites W1973837499 @default.
- W4306362017 cites W1974128502 @default.
- W4306362017 cites W1974241409 @default.
- W4306362017 cites W1974530349 @default.
- W4306362017 cites W1975612877 @default.
- W4306362017 cites W1975642651 @default.
- W4306362017 cites W1976698065 @default.
- W4306362017 cites W1977701732 @default.
- W4306362017 cites W1979253402 @default.
- W4306362017 cites W1980972379 @default.
- W4306362017 cites W1983055247 @default.
- W4306362017 cites W1983276056 @default.
- W4306362017 cites W1983344122 @default.
- W4306362017 cites W1984090535 @default.
- W4306362017 cites W1984158636 @default.
- W4306362017 cites W1984159784 @default.
- W4306362017 cites W1984453879 @default.
- W4306362017 cites W1984621921 @default.
- W4306362017 cites W1985113364 @default.
- W4306362017 cites W1985736108 @default.
- W4306362017 cites W1986694073 @default.
- W4306362017 cites W1986976113 @default.
- W4306362017 cites W1987343571 @default.
- W4306362017 cites W1987642183 @default.
- W4306362017 cites W1988864736 @default.
- W4306362017 cites W1991710558 @default.
- W4306362017 cites W1991761103 @default.
- W4306362017 cites W1992139451 @default.
- W4306362017 cites W1992250994 @default.
- W4306362017 cites W1992643899 @default.
- W4306362017 cites W1994063020 @default.
- W4306362017 cites W1994105285 @default.