FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306366802> ?p ?o ?g. }

• W4306366802 endingPage "5044" @default.
• W4306366802 startingPage "5044" @default.
• W4306366802 abstract "Renal medullary carcinomas (RMC) are rare aggressive tumors of the kidneys, characterized by a loss of SMARCB1. Characteristically, these tumors arise in patients with sickle cell trait or other hemoglobinopathies. Recent characterization efforts have unraveled oncogenic pathways that drive tumorigenesis. Among these, gene sets that characterize replicative stress and the innate immune response are upregulated in RMCs. Despite comprehensive genetic and transcriptomic characterizations, commonalities or differences to other SMARCB1 deficient entities so far have not been investigated. We analyzed the methylome of seven primary RMC and compared it to other SMARCB1 deficient entities such as rhabdoid tumors (RT) and epithelioid sarcomas using 850 K methylation arrays. Moreover, we evaluated the differential gene expression of RMC using RNA-sequencing in comparison to other rhabdoid tumors. In accordance with previous gene expression data, we found that RMCs separate from other SMARCB1 deficient entities, pointing to a potentially different cell of origin and a role of additional genetic aberrations that may drive tumorigenesis and thus alter the methylome when compared to rhabdoid tumors. In a focused analysis of genes that are important for nephrogenesis, we particularly detected genes that govern early nephrogenesis such as FOXI1 to be hypomethylated and expressed at high levels in RMC. Overall, our analyses underscore the fact that RMCs represent a separate entity with limited similarities to rhabdoid tumors, warranting specific treatment tailored to the aggressiveness of the disease." @default.
• W4306366802 created "2022-10-17" @default.
• W4306366802 creator A5003119579 @default.
• W4306366802 creator A5021550857 @default.
• W4306366802 creator A5042661460 @default.
• W4306366802 creator A5049527133 @default.
• W4306366802 creator A5059749084 @default.
• W4306366802 creator A5069803667 @default.
• W4306366802 date "2022-10-14" @default.
• W4306366802 modified "2023-10-18" @default.
• W4306366802 title "Renal Medullary Carcinomas Harbor a Distinct Methylation Phenotype and Display Aberrant Methylation of Genes Related to Early Nephrogenesis" @default.
• W4306366802 cites W1501609166 @default.
• W4306366802 cites W1948128888 @default.
• W4306366802 cites W1985408575 @default.
• W4306366802 cites W2011115717 @default.
• W4306366802 cites W2040730809 @default.
• W4306366802 cites W2048121496 @default.
• W4306366802 cites W2052747035 @default.
• W4306366802 cites W2055279984 @default.
• W4306366802 cites W2079743297 @default.
• W4306366802 cites W2093734994 @default.
• W4306366802 cites W2103233599 @default.
• W4306366802 cites W2132310381 @default.
• W4306366802 cites W2143323073 @default.
• W4306366802 cites W2149588159 @default.
• W4306366802 cites W2194206656 @default.
• W4306366802 cites W2286341552 @default.
• W4306366802 cites W2335159862 @default.
• W4306366802 cites W2460673340 @default.
• W4306366802 cites W2514121045 @default.
• W4306366802 cites W2607935491 @default.
• W4306366802 cites W2793269959 @default.
• W4306366802 cites W2794375114 @default.
• W4306366802 cites W2804455338 @default.
• W4306366802 cites W2808615542 @default.
• W4306366802 cites W2890964319 @default.
• W4306366802 cites W2891539948 @default.
• W4306366802 cites W2893494891 @default.
• W4306366802 cites W2898199771 @default.
• W4306366802 cites W2903048998 @default.
• W4306366802 cites W2937391264 @default.
• W4306366802 cites W2949756524 @default.
• W4306366802 cites W2985435545 @default.
• W4306366802 cites W2986901366 @default.
• W4306366802 cites W2991701263 @default.
• W4306366802 cites W2998197281 @default.
• W4306366802 cites W3014736130 @default.
• W4306366802 cites W3023801326 @default.
• W4306366802 cites W3111326859 @default.
• W4306366802 cites W3203646638 @default.
• W4306366802 cites W4255028331 @default.
• W4306366802 doi "https://doi.org/10.3390/cancers14205044" @default.
• W4306366802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36291828" @default.
• W4306366802 hasPublicationYear "2022" @default.
• W4306366802 type Work @default.
• W4306366802 citedByCount "0" @default.
• W4306366802 crossrefType "journal-article" @default.
• W4306366802 hasAuthorship W4306366802A5003119579 @default.
• W4306366802 hasAuthorship W4306366802A5021550857 @default.
• W4306366802 hasAuthorship W4306366802A5042661460 @default.
• W4306366802 hasAuthorship W4306366802A5049527133 @default.
• W4306366802 hasAuthorship W4306366802A5059749084 @default.
• W4306366802 hasAuthorship W4306366802A5069803667 @default.
• W4306366802 hasBestOaLocation W43063668021 @default.
• W4306366802 hasConcept C104317684 @default.
• W4306366802 hasConcept C127716648 @default.
• W4306366802 hasConcept C150194340 @default.
• W4306366802 hasConcept C162317418 @default.
• W4306366802 hasConcept C167227067 @default.
• W4306366802 hasConcept C177450382 @default.
• W4306366802 hasConcept C190727270 @default.
• W4306366802 hasConcept C33288867 @default.
• W4306366802 hasConcept C41091548 @default.
• W4306366802 hasConcept C502942594 @default.
• W4306366802 hasConcept C54355233 @default.
• W4306366802 hasConcept C555283112 @default.
• W4306366802 hasConcept C86803240 @default.
• W4306366802 hasConceptScore W4306366802C104317684 @default.
• W4306366802 hasConceptScore W4306366802C127716648 @default.
• W4306366802 hasConceptScore W4306366802C150194340 @default.
• W4306366802 hasConceptScore W4306366802C162317418 @default.
• W4306366802 hasConceptScore W4306366802C167227067 @default.
• W4306366802 hasConceptScore W4306366802C177450382 @default.
• W4306366802 hasConceptScore W4306366802C190727270 @default.
• W4306366802 hasConceptScore W4306366802C33288867 @default.
• W4306366802 hasConceptScore W4306366802C41091548 @default.
• W4306366802 hasConceptScore W4306366802C502942594 @default.
• W4306366802 hasConceptScore W4306366802C54355233 @default.
• W4306366802 hasConceptScore W4306366802C555283112 @default.
• W4306366802 hasConceptScore W4306366802C86803240 @default.
• W4306366802 hasIssue "20" @default.
• W4306366802 hasLocation W43063668021 @default.
• W4306366802 hasLocation W43063668022 @default.
• W4306366802 hasLocation W43063668023 @default.
• W4306366802 hasLocation W43063668024 @default.
• W4306366802 hasOpenAccess W4306366802 @default.
• W4306366802 hasPrimaryLocation W43063668021 @default.
• W4306366802 hasRelatedWork W1982470198 @default.

• next