FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306366852> ?p ?o ?g. }

• W4306366852 endingPage "5031" @default.
• W4306366852 startingPage "5031" @default.
• W4306366852 abstract "As microRNA-142 (miR-142) is the only human microRNA gene where mutations have consistently been found in about 20% of all cases of diffuse large B-cell lymphoma (DLBCL), we wanted to determine the impact of miR-142 inactivation on protein expression of DLBCL cell lines.miR-142 was deleted by CRISPR/Cas9 knockout in cell lines from DLBCL.By proteome analyses, miR-142 knockout resulted in a consistent up-regulation of 52 but also down-regulation of 41 proteins in GC-DLBCL lines BJAB and SUDHL4. Various mitochondrial ribosomal proteins were up-regulated in line with their pro-tumorigenic properties, while proteins necessary for MHC-I presentation were down-regulated in accordance with the finding that miR-142 knockout mice have a defective immune response. CFL2, CLIC4, STAU1, and TWF1 are known targets of miR-142, and we could additionally confirm AKT1S1, CCNB1, LIMA1, and TFRC as new targets of miR-142-3p or -5p.Seed-sequence mutants of miR-142 confirmed potential targets and novel targets of miRNAs can be identified in miRNA knockout cell lines. Due to the complex contribution of miRNAs within cellular regulatory networks, in particular when miRNAs highly present in RISC complexes are replaced by other miRNAs, primary effects on gene expression may be covered by secondary layers of regulation." @default.
• W4306366852 created "2022-10-17" @default.
• W4306366852 creator A5010867829 @default.
• W4306366852 creator A5013727205 @default.
• W4306366852 creator A5015424965 @default.
• W4306366852 creator A5021006948 @default.
• W4306366852 creator A5023390553 @default.
• W4306366852 creator A5027597205 @default.
• W4306366852 creator A5032737258 @default.
• W4306366852 creator A5034352333 @default.
• W4306366852 creator A5037299634 @default.
• W4306366852 creator A5049468599 @default.
• W4306366852 creator A5054514348 @default.
• W4306366852 creator A5063365367 @default.
• W4306366852 creator A5069175552 @default.
• W4306366852 creator A5073943430 @default.
• W4306366852 creator A5074653262 @default.
• W4306366852 creator A5085594740 @default.
• W4306366852 date "2022-10-14" @default.
• W4306366852 modified "2023-09-27" @default.
• W4306366852 title "Changes of Protein Expression after CRISPR/Cas9 Knockout of miRNA-142 in Cell Lines Derived from Diffuse Large B-Cell Lymphoma" @default.
• W4306366852 cites W1539353539 @default.
• W4306366852 cites W1621440205 @default.
• W4306366852 cites W1803838592 @default.
• W4306366852 cites W1933299947 @default.
• W4306366852 cites W1974254202 @default.
• W4306366852 cites W1976980352 @default.
• W4306366852 cites W1984771273 @default.
• W4306366852 cites W1988202153 @default.
• W4306366852 cites W1990022083 @default.
• W4306366852 cites W1993652391 @default.
• W4306366852 cites W1995232179 @default.
• W4306366852 cites W1996963134 @default.
• W4306366852 cites W2000946983 @default.
• W4306366852 cites W2002995168 @default.
• W4306366852 cites W2030499735 @default.
• W4306366852 cites W2036727594 @default.
• W4306366852 cites W2045399297 @default.
• W4306366852 cites W2047748450 @default.
• W4306366852 cites W2055167407 @default.
• W4306366852 cites W2060897864 @default.
• W4306366852 cites W2064254099 @default.
• W4306366852 cites W2070765029 @default.
• W4306366852 cites W2075039650 @default.
• W4306366852 cites W2080752012 @default.
• W4306366852 cites W2099719455 @default.
• W4306366852 cites W2102612894 @default.
• W4306366852 cites W2110300245 @default.
• W4306366852 cites W2110857241 @default.
• W4306366852 cites W2111655556 @default.
• W4306366852 cites W2113319942 @default.
• W4306366852 cites W2117692326 @default.
• W4306366852 cites W2128635872 @default.
• W4306366852 cites W2129682764 @default.
• W4306366852 cites W2135007926 @default.
• W4306366852 cites W2158217645 @default.
• W4306366852 cites W2162674813 @default.
• W4306366852 cites W2162877061 @default.
• W4306366852 cites W2163506769 @default.
• W4306366852 cites W2193707124 @default.
• W4306366852 cites W2278880049 @default.
• W4306366852 cites W2295919652 @default.
• W4306366852 cites W2325004843 @default.
• W4306366852 cites W2345035704 @default.
• W4306366852 cites W2429248020 @default.
• W4306366852 cites W2432055868 @default.
• W4306366852 cites W2461798448 @default.
• W4306366852 cites W2463195069 @default.
• W4306366852 cites W2470277042 @default.
• W4306366852 cites W2516584807 @default.
• W4306366852 cites W2534266625 @default.
• W4306366852 cites W2541856909 @default.
• W4306366852 cites W2568089639 @default.
• W4306366852 cites W2587954422 @default.
• W4306366852 cites W2597632520 @default.
• W4306366852 cites W2608190552 @default.
• W4306366852 cites W2610284834 @default.
• W4306366852 cites W2753580600 @default.
• W4306366852 cites W2760706849 @default.
• W4306366852 cites W2765536161 @default.
• W4306366852 cites W2768096340 @default.
• W4306366852 cites W2790033844 @default.
• W4306366852 cites W2800000662 @default.
• W4306366852 cites W2800497993 @default.
• W4306366852 cites W2890187240 @default.
• W4306366852 cites W2896348655 @default.
• W4306366852 cites W2900391496 @default.
• W4306366852 cites W2900569176 @default.
• W4306366852 cites W2901692650 @default.
• W4306366852 cites W2902116368 @default.
• W4306366852 cites W2912904176 @default.
• W4306366852 cites W2916326638 @default.
• W4306366852 cites W2936293163 @default.
• W4306366852 cites W2949758352 @default.
• W4306366852 cites W2952944787 @default.
• W4306366852 cites W2964069817 @default.
• W4306366852 cites W2965461038 @default.
• W4306366852 cites W2970938906 @default.

• next