Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306367174> ?p ?o ?g. }
- W4306367174 endingPage "3226" @default.
- W4306367174 startingPage "3226" @default.
- W4306367174 abstract "Background: Lung cancer (LC) tissue for immunological characterization is often scarce. We explored and compared T cell characteristics between broncho-alveolar lavage from tumor affected (t-BAL) and contralateral lung (cl-BAL), with matched peripheral blood (PB). Methods: BAL and PB were collected during bronchoscopy for diagnostic and/or therapeutic purposes in patients with monolateral primary lesion. Results: Of 33 patients undergoing BAL and PB sampling, 21 had histologically-confirmed LC. Most cases were locally-advanced or metastatic non-small cell LC. T cell characteristics were not significantly different in t-BAL vs. cl-BAL. Compared to PB, CD8 T cells in BAL presented features of immune activation and exhaustion (high PD-1, low IFN-g production). Accordingly, regulatory CD4 T cells were also higher in BAL vs. PB. When dichotomizing T cell density in t-BAL in high and low, we found that PD-L1 expression in LC was associated with T cell density in t-BAL. T-BAL with high T cell density had higher %IFN-g+CD8 T cells and lower %T-regs. Conclusion: In BAL from advanced LC patients, T cells present features of exhaustion. T cells in t-BAL could be the best surrogate of tumor-infiltrating T cell, and future studies should evaluate T cell phenotype and density as potential biomarkers for cancer immunotherapy outcome." @default.
- W4306367174 created "2022-10-17" @default.
- W4306367174 creator A5000995161 @default.
- W4306367174 creator A5007575010 @default.
- W4306367174 creator A5016597914 @default.
- W4306367174 creator A5026153195 @default.
- W4306367174 creator A5036568332 @default.
- W4306367174 creator A5037759399 @default.
- W4306367174 creator A5037932676 @default.
- W4306367174 creator A5039778094 @default.
- W4306367174 creator A5040742554 @default.
- W4306367174 creator A5041240875 @default.
- W4306367174 creator A5041463664 @default.
- W4306367174 creator A5050303493 @default.
- W4306367174 creator A5056915317 @default.
- W4306367174 creator A5062403027 @default.
- W4306367174 creator A5065720871 @default.
- W4306367174 creator A5072032174 @default.
- W4306367174 creator A5075028644 @default.
- W4306367174 creator A5076067136 @default.
- W4306367174 creator A5079600573 @default.
- W4306367174 creator A5084174977 @default.
- W4306367174 creator A5087054688 @default.
- W4306367174 creator A5088683354 @default.
- W4306367174 date "2022-10-14" @default.
- W4306367174 modified "2023-09-27" @default.
- W4306367174 title "Comparing T Cell Subsets in Broncho-Alveolar Lavage (BAL) and Peripheral Blood in Patients with Advanced Lung Cancer" @default.
- W4306367174 cites W1483442587 @default.
- W4306367174 cites W1987735044 @default.
- W4306367174 cites W2028232370 @default.
- W4306367174 cites W2103938724 @default.
- W4306367174 cites W2124427232 @default.
- W4306367174 cites W2163351155 @default.
- W4306367174 cites W2298468092 @default.
- W4306367174 cites W2340166080 @default.
- W4306367174 cites W2404485673 @default.
- W4306367174 cites W2560367415 @default.
- W4306367174 cites W2592666036 @default.
- W4306367174 cites W2756492491 @default.
- W4306367174 cites W2794713051 @default.
- W4306367174 cites W2804957255 @default.
- W4306367174 cites W2807534769 @default.
- W4306367174 cites W2911865233 @default.
- W4306367174 cites W2914335731 @default.
- W4306367174 cites W2921047712 @default.
- W4306367174 cites W2939240280 @default.
- W4306367174 cites W2969643975 @default.
- W4306367174 cites W2997141683 @default.
- W4306367174 cites W2999417355 @default.
- W4306367174 cites W2999475127 @default.
- W4306367174 cites W3003415550 @default.
- W4306367174 cites W3018791677 @default.
- W4306367174 cites W3021264705 @default.
- W4306367174 cites W3082740939 @default.
- W4306367174 cites W3118310819 @default.
- W4306367174 cites W3135105663 @default.
- W4306367174 cites W3158306799 @default.
- W4306367174 cites W3164393174 @default.
- W4306367174 cites W3175170112 @default.
- W4306367174 cites W3194569086 @default.
- W4306367174 cites W4210992155 @default.
- W4306367174 doi "https://doi.org/10.3390/cells11203226" @default.
- W4306367174 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36291098" @default.
- W4306367174 hasPublicationYear "2022" @default.
- W4306367174 type Work @default.
- W4306367174 citedByCount "0" @default.
- W4306367174 crossrefType "journal-article" @default.
- W4306367174 hasAuthorship W4306367174A5000995161 @default.
- W4306367174 hasAuthorship W4306367174A5007575010 @default.
- W4306367174 hasAuthorship W4306367174A5016597914 @default.
- W4306367174 hasAuthorship W4306367174A5026153195 @default.
- W4306367174 hasAuthorship W4306367174A5036568332 @default.
- W4306367174 hasAuthorship W4306367174A5037759399 @default.
- W4306367174 hasAuthorship W4306367174A5037932676 @default.
- W4306367174 hasAuthorship W4306367174A5039778094 @default.
- W4306367174 hasAuthorship W4306367174A5040742554 @default.
- W4306367174 hasAuthorship W4306367174A5041240875 @default.
- W4306367174 hasAuthorship W4306367174A5041463664 @default.
- W4306367174 hasAuthorship W4306367174A5050303493 @default.
- W4306367174 hasAuthorship W4306367174A5056915317 @default.
- W4306367174 hasAuthorship W4306367174A5062403027 @default.
- W4306367174 hasAuthorship W4306367174A5065720871 @default.
- W4306367174 hasAuthorship W4306367174A5072032174 @default.
- W4306367174 hasAuthorship W4306367174A5075028644 @default.
- W4306367174 hasAuthorship W4306367174A5076067136 @default.
- W4306367174 hasAuthorship W4306367174A5079600573 @default.
- W4306367174 hasAuthorship W4306367174A5084174977 @default.
- W4306367174 hasAuthorship W4306367174A5087054688 @default.
- W4306367174 hasAuthorship W4306367174A5088683354 @default.
- W4306367174 hasBestOaLocation W43063671741 @default.
- W4306367174 hasConcept C126322002 @default.
- W4306367174 hasConcept C137061746 @default.
- W4306367174 hasConcept C142724271 @default.
- W4306367174 hasConcept C1491633281 @default.
- W4306367174 hasConcept C154317977 @default.
- W4306367174 hasConcept C167672396 @default.
- W4306367174 hasConcept C202751555 @default.
- W4306367174 hasConcept C203014093 @default.