FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306381779> ?p ?o ?g. }

• W4306381779 abstract "The skeletal muscle tissue can adapt to exercise and environmental stressors with a remarkable plasticity. Prolonged cold stress exposure has been associated to increased skeletal muscle capillarization. Angioadaptation refers to the coordinated molecular and cellular processes that influence the remodeling of skeletal muscle microvasculature. Two cell types are central to angioadaptation: the myocytes, representing an important source of angiokines; and the skeletal muscle endothelial cell (SMECs), targets of these angiokines and main constituents of muscle capillaries. The influence of cold stress on skeletal muscle angioadaptation remains largely unknown, particularly with respect to myocyte-specific angiokines secretion or endothelial cell angioadaptive responses. Here, we use an in vitro model to investigate the impact of cold stress (28°C versus 37°C) on C2C12 myotubes and SMECs. Our main objectives were to evaluate: 1) the direct impact of cold stress on C2C12 cellular expression of angiokines and their release in the extracellular environment; 2) the indirect impact of cold stress on SMECs migration via these C2C12-derived angiokines; and 3) the direct effect of cold stress on SMECs angioadaptive responses, including migration, proliferation, and the activation of the vascular endothelial growth factor receptor-2 (VEGFR2). Cold stress reduced the secretion of angiokines in C2C12 myotubes culture media irrespective their pro-angiogenic or angiostatic nature. In SMECs, cold stress abrogated cell proliferation and reduced the activation of VEGFR2 despite a greater expression of this receptor. Finally, SMECs pre-conditioned to cold stress displayed an enhanced migratory response when migration was stimulated in rewarming conditions. Altogether our results suggest that cold stress may be overall angiostatic. However, cold stress accompanied by rewarming may be seen as a pro-angiogenic stressor for SMECs. This observation questions the potential for using pre-cooling in sport-performance or therapeutic exercise prescription to enhance skeletal muscle angioadaptive responses to exercise." @default.
• W4306381779 created "2022-10-17" @default.
• W4306381779 creator A5021551592 @default.
• W4306381779 creator A5032517154 @default.
• W4306381779 creator A5077807082 @default.
• W4306381779 date "2022-10-17" @default.
• W4306381779 modified "2023-09-25" @default.
• W4306381779 title "Angiostatic freeze or angiogenic move? Acute cold stress prevents angiokine secretion from murine myotubes but primes primary endothelial cells for greater migratory capacity" @default.
• W4306381779 cites W1483918663 @default.
• W4306381779 cites W1494785414 @default.
• W4306381779 cites W1554055837 @default.
• W4306381779 cites W1567632829 @default.
• W4306381779 cites W1605022460 @default.
• W4306381779 cites W1915963872 @default.
• W4306381779 cites W1944809462 @default.
• W4306381779 cites W1967788538 @default.
• W4306381779 cites W1971501239 @default.
• W4306381779 cites W1972174983 @default.
• W4306381779 cites W1974228020 @default.
• W4306381779 cites W1975834259 @default.
• W4306381779 cites W1982912692 @default.
• W4306381779 cites W1986361201 @default.
• W4306381779 cites W2006619771 @default.
• W4306381779 cites W2007740489 @default.
• W4306381779 cites W2007906731 @default.
• W4306381779 cites W2021404690 @default.
• W4306381779 cites W2022130519 @default.
• W4306381779 cites W2030362048 @default.
• W4306381779 cites W2042443353 @default.
• W4306381779 cites W2044039324 @default.
• W4306381779 cites W2046525214 @default.
• W4306381779 cites W2055207619 @default.
• W4306381779 cites W2057657670 @default.
• W4306381779 cites W2059431829 @default.
• W4306381779 cites W2060302807 @default.
• W4306381779 cites W2070664770 @default.
• W4306381779 cites W2083405476 @default.
• W4306381779 cites W2086891360 @default.
• W4306381779 cites W2088057986 @default.
• W4306381779 cites W2096048497 @default.
• W4306381779 cites W2105599117 @default.
• W4306381779 cites W2105720678 @default.
• W4306381779 cites W2109204497 @default.
• W4306381779 cites W2114723564 @default.
• W4306381779 cites W2115446927 @default.
• W4306381779 cites W2122140047 @default.
• W4306381779 cites W2123727938 @default.
• W4306381779 cites W2130995336 @default.
• W4306381779 cites W2133897282 @default.
• W4306381779 cites W2139927700 @default.
• W4306381779 cites W2140609274 @default.
• W4306381779 cites W2147918847 @default.
• W4306381779 cites W2149277503 @default.
• W4306381779 cites W2159428568 @default.
• W4306381779 cites W2164171778 @default.
• W4306381779 cites W2184397596 @default.
• W4306381779 cites W2188047995 @default.
• W4306381779 cites W2202803087 @default.
• W4306381779 cites W2275028861 @default.
• W4306381779 cites W2277947727 @default.
• W4306381779 cites W2279374144 @default.
• W4306381779 cites W2282342405 @default.
• W4306381779 cites W2302120004 @default.
• W4306381779 cites W2344839589 @default.
• W4306381779 cites W2345969280 @default.
• W4306381779 cites W2414244820 @default.
• W4306381779 cites W2528453571 @default.
• W4306381779 cites W2767526169 @default.
• W4306381779 cites W2789019272 @default.
• W4306381779 cites W2898310387 @default.
• W4306381779 cites W2902555929 @default.
• W4306381779 cites W2914996014 @default.
• W4306381779 cites W2918622940 @default.
• W4306381779 cites W2948342670 @default.
• W4306381779 cites W2959707418 @default.
• W4306381779 cites W2970341561 @default.
• W4306381779 cites W3083659958 @default.
• W4306381779 cites W3086952308 @default.
• W4306381779 cites W3099076257 @default.
• W4306381779 cites W3152146330 @default.
• W4306381779 cites W3155216012 @default.
• W4306381779 cites W3156575565 @default.
• W4306381779 cites W3157447267 @default.
• W4306381779 cites W3196336590 @default.
• W4306381779 cites W3216682199 @default.
• W4306381779 cites W623999939 @default.
• W4306381779 doi "https://doi.org/10.3389/fphys.2022.975652" @default.
• W4306381779 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36324307" @default.
• W4306381779 hasPublicationYear "2022" @default.
• W4306381779 type Work @default.
• W4306381779 citedByCount "0" @default.
• W4306381779 crossrefType "journal-article" @default.
• W4306381779 hasAuthorship W4306381779A5021551592 @default.
• W4306381779 hasAuthorship W4306381779A5032517154 @default.
• W4306381779 hasAuthorship W4306381779A5077807082 @default.
• W4306381779 hasBestOaLocation W43063817791 @default.
• W4306381779 hasConcept C123012128 @default.
• W4306381779 hasConcept C126322002 @default.
• W4306381779 hasConcept C134018914 @default.
• W4306381779 hasConcept C202751555 @default.

• next