FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306381808> ?p ?o ?g. }

• W4306381808 endingPage "13354" @default.
• W4306381808 startingPage "13354" @default.
• W4306381808 abstract "Chronic low back pain (CLBP) due to osteoarthritis represents a therapeutic challenge worldwide. Opioids are extensively used to treat such pain, but the development of tolerance, i.e., less susceptibility to the effects of the opioid, which can result in a need for higher doses to achieve the same analgesic effect, may limit their use. Animal models suggest that ultra-low doses of opioid antagonists combined with opioid agonists can decrease or block the development of opioid tolerance. In this retrospective study, we tested this hypothesis in humans. In 2019, 53 patients suffering from CLBP were treated with either Oxycodone and Naloxone Prolonged Release (27 patients, OXN patients) or Oxycodone Controlled Release (26 patients, OXY patients). The follow-up period lasted 2 years, during which 10 patients discontinued the treatment, 5 out of each group. The remaining 43 patients reached and maintained the targeted pain relief, but at 18 and 24 months, the OXY patients showed a significantly higher oxycodone consumption than OXN patients to reach the same level of pain relief. No cases of respiratory depression or opioid abuse were reported. There were no significant differences in the incidence of adverse effects between the two treatments, except for constipation, more common in OXY patients. From our results, we can affirm that a long-term opioid treatment with oxycodone-naloxone combination, when compared with oxycodone only, may significantly hinder the development of opioid tolerance. We were also able to confirm, in our cohort, the well known positive effect of naloxone in terms of opioid-induced bowel dysfunction incidence reduction." @default.
• W4306381808 created "2022-10-17" @default.
• W4306381808 creator A5019859846 @default.
• W4306381808 creator A5022463569 @default.
• W4306381808 creator A5024125343 @default.
• W4306381808 creator A5047796715 @default.
• W4306381808 creator A5048895004 @default.
• W4306381808 creator A5057153699 @default.
• W4306381808 creator A5057876293 @default.
• W4306381808 creator A5059138853 @default.
• W4306381808 creator A5062251926 @default.
• W4306381808 creator A5075059224 @default.
• W4306381808 creator A5084774263 @default.
• W4306381808 creator A5090366160 @default.
• W4306381808 date "2022-10-16" @default.
• W4306381808 modified "2023-10-16" @default.
• W4306381808 title "Oxycodone-Naloxone Combination Hinders Opioid Consumption in Osteoarthritic Chronic Low Back Pain: A Retrospective Study with Two Years of Follow-Up" @default.
• W4306381808 cites W1556179618 @default.
• W4306381808 cites W1561275320 @default.
• W4306381808 cites W1575537386 @default.
• W4306381808 cites W1622150373 @default.
• W4306381808 cites W1809058072 @default.
• W4306381808 cites W1891696008 @default.
• W4306381808 cites W1945672276 @default.
• W4306381808 cites W1978242526 @default.
• W4306381808 cites W1979282061 @default.
• W4306381808 cites W1984377490 @default.
• W4306381808 cites W1992314523 @default.
• W4306381808 cites W199724056 @default.
• W4306381808 cites W2003883053 @default.
• W4306381808 cites W2003970587 @default.
• W4306381808 cites W2009383738 @default.
• W4306381808 cites W2009642026 @default.
• W4306381808 cites W2021665715 @default.
• W4306381808 cites W2040668587 @default.
• W4306381808 cites W2040832386 @default.
• W4306381808 cites W2048029697 @default.
• W4306381808 cites W2049608435 @default.
• W4306381808 cites W2052308524 @default.
• W4306381808 cites W2058589594 @default.
• W4306381808 cites W2073523765 @default.
• W4306381808 cites W2082276527 @default.
• W4306381808 cites W2108163830 @default.
• W4306381808 cites W2109480445 @default.
• W4306381808 cites W2113933207 @default.
• W4306381808 cites W2124990868 @default.
• W4306381808 cites W2126273530 @default.
• W4306381808 cites W2128848460 @default.
• W4306381808 cites W2145783290 @default.
• W4306381808 cites W2162638563 @default.
• W4306381808 cites W2163255559 @default.
• W4306381808 cites W2163861668 @default.
• W4306381808 cites W2186287946 @default.
• W4306381808 cites W2587222353 @default.
• W4306381808 cites W2612284626 @default.
• W4306381808 cites W2766338780 @default.
• W4306381808 cites W2794524455 @default.
• W4306381808 cites W2806045085 @default.
• W4306381808 cites W2889252324 @default.
• W4306381808 cites W2896006201 @default.
• W4306381808 cites W2914151791 @default.
• W4306381808 cites W2914174171 @default.
• W4306381808 cites W2977629639 @default.
• W4306381808 cites W3132839697 @default.
• W4306381808 cites W3137938605 @default.
• W4306381808 cites W3209986775 @default.
• W4306381808 cites W4205928251 @default.
• W4306381808 cites W4234097198 @default.
• W4306381808 doi "https://doi.org/10.3390/ijerph192013354" @default.
• W4306381808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36293936" @default.
• W4306381808 hasPublicationYear "2022" @default.
• W4306381808 type Work @default.
• W4306381808 citedByCount "3" @default.
• W4306381808 countsByYear W43063818082022 @default.
• W4306381808 countsByYear W43063818082023 @default.
• W4306381808 crossrefType "journal-article" @default.
• W4306381808 hasAuthorship W4306381808A5019859846 @default.
• W4306381808 hasAuthorship W4306381808A5022463569 @default.
• W4306381808 hasAuthorship W4306381808A5024125343 @default.
• W4306381808 hasAuthorship W4306381808A5047796715 @default.
• W4306381808 hasAuthorship W4306381808A5048895004 @default.
• W4306381808 hasAuthorship W4306381808A5057153699 @default.
• W4306381808 hasAuthorship W4306381808A5057876293 @default.
• W4306381808 hasAuthorship W4306381808A5059138853 @default.
• W4306381808 hasAuthorship W4306381808A5062251926 @default.
• W4306381808 hasAuthorship W4306381808A5075059224 @default.
• W4306381808 hasAuthorship W4306381808A5084774263 @default.
• W4306381808 hasAuthorship W4306381808A5090366160 @default.
• W4306381808 hasBestOaLocation W43063818081 @default.
• W4306381808 hasConcept C126322002 @default.
• W4306381808 hasConcept C167135981 @default.
• W4306381808 hasConcept C170493617 @default.
• W4306381808 hasConcept C1862650 @default.
• W4306381808 hasConcept C197934379 @default.
• W4306381808 hasConcept C2776029756 @default.
• W4306381808 hasConcept C2777389121 @default.
• W4306381808 hasConcept C2778750930 @default.
• W4306381808 hasConcept C2780820201 @default.

• next