FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306382104> ?p ?o ?g. }

• W4306382104 abstract "Osteoporosis is a disease that impacts the elderly. Low estrogen is related to changes in DNA methylation and consequent alterations in gene expression, leading to a new direction in research related to the pathophysiology of osteoporosis. We constructed an Ovariectomized (OVX) mouse model in our study, and the mouse models had osteoporosis based on the phenotype and methylation levels in the mouse's bone. Furthermore, the methylation level of the OVX mice was significantly changed compared to that of SHAM mice. Therefore, we performed genome-level analysis on the mouse model using transcriptome and Whole Genome Bisulfite Sequencing (WGBS) by combining the data of two omics and discovered that the changes in gene expression level caused by osteoporosis primarily focused on the decrease of bone and muscle development and the activation of the immune system. According to intersection analysis of methylation and transcriptome data, the differentially expressed genes and pathways are consistent with the differentially expressed methylation locations and regions. Further, the differentially expressed methylation sites were mainly concentrated in promoters, exons, and other critical functional regions of essential differentially expressed genes. This is also the primary cause of gene differential expression variations, indicating that estrogen deficiency might regulate gene expression by altering methylation modification, leading to osteoporosis. We demonstrated the clinical value of methylation modification research, and these findings would improve the current understanding of underlying molecular mechanisms of osteoporosis incidence and development and provide new ideas for early detection and treatment of osteoporosis." @default.
• W4306382104 created "2022-10-17" @default.
• W4306382104 creator A5000936951 @default.
• W4306382104 creator A5002069152 @default.
• W4306382104 creator A5004437840 @default.
• W4306382104 creator A5004791791 @default.
• W4306382104 creator A5013412892 @default.
• W4306382104 creator A5039728001 @default.
• W4306382104 creator A5046287902 @default.
• W4306382104 creator A5060643741 @default.
• W4306382104 creator A5064842058 @default.
• W4306382104 creator A5065482772 @default.
• W4306382104 creator A5066525634 @default.
• W4306382104 creator A5074755396 @default.
• W4306382104 creator A5084022869 @default.
• W4306382104 date "2022-10-17" @default.
• W4306382104 modified "2023-10-16" @default.
• W4306382104 title "Mechanisms of estrogen deficiency-induced osteoporosis based on transcriptome and DNA methylation" @default.
• W4306382104 cites W1964891491 @default.
• W4306382104 cites W1978038109 @default.
• W4306382104 cites W2033329654 @default.
• W4306382104 cites W2081197989 @default.
• W4306382104 cites W2108664872 @default.
• W4306382104 cites W2170280274 @default.
• W4306382104 cites W2170830174 @default.
• W4306382104 cites W2199847904 @default.
• W4306382104 cites W2305364952 @default.
• W4306382104 cites W2412992442 @default.
• W4306382104 cites W2525941243 @default.
• W4306382104 cites W256671842 @default.
• W4306382104 cites W2590579283 @default.
• W4306382104 cites W2737885423 @default.
• W4306382104 cites W2762510801 @default.
• W4306382104 cites W2769513749 @default.
• W4306382104 cites W2801091160 @default.
• W4306382104 cites W2810699323 @default.
• W4306382104 cites W2883635070 @default.
• W4306382104 cites W2884426132 @default.
• W4306382104 cites W2900423390 @default.
• W4306382104 cites W2923907660 @default.
• W4306382104 cites W2994655911 @default.
• W4306382104 cites W3010468069 @default.
• W4306382104 cites W3024812655 @default.
• W4306382104 cites W3038248580 @default.
• W4306382104 cites W3088859470 @default.
• W4306382104 cites W3092292927 @default.
• W4306382104 cites W3155543161 @default.
• W4306382104 cites W3194665116 @default.
• W4306382104 cites W3209735370 @default.
• W4306382104 cites W3211014030 @default.
• W4306382104 cites W4211221406 @default.
• W4306382104 doi "https://doi.org/10.3389/fcell.2022.1011725" @default.
• W4306382104 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36325359" @default.
• W4306382104 hasPublicationYear "2022" @default.
• W4306382104 type Work @default.
• W4306382104 citedByCount "3" @default.
• W4306382104 countsByYear W43063821042023 @default.
• W4306382104 crossrefType "journal-article" @default.
• W4306382104 hasAuthorship W4306382104A5000936951 @default.
• W4306382104 hasAuthorship W4306382104A5002069152 @default.
• W4306382104 hasAuthorship W4306382104A5004437840 @default.
• W4306382104 hasAuthorship W4306382104A5004791791 @default.
• W4306382104 hasAuthorship W4306382104A5013412892 @default.
• W4306382104 hasAuthorship W4306382104A5039728001 @default.
• W4306382104 hasAuthorship W4306382104A5046287902 @default.
• W4306382104 hasAuthorship W4306382104A5060643741 @default.
• W4306382104 hasAuthorship W4306382104A5064842058 @default.
• W4306382104 hasAuthorship W4306382104A5065482772 @default.
• W4306382104 hasAuthorship W4306382104A5066525634 @default.
• W4306382104 hasAuthorship W4306382104A5074755396 @default.
• W4306382104 hasAuthorship W4306382104A5084022869 @default.
• W4306382104 hasBestOaLocation W43063821041 @default.
• W4306382104 hasConcept C104317684 @default.
• W4306382104 hasConcept C134018914 @default.
• W4306382104 hasConcept C150194340 @default.
• W4306382104 hasConcept C162317418 @default.
• W4306382104 hasConcept C165864922 @default.
• W4306382104 hasConcept C190727270 @default.
• W4306382104 hasConcept C2776541429 @default.
• W4306382104 hasConcept C33288867 @default.
• W4306382104 hasConcept C41091548 @default.
• W4306382104 hasConcept C54355233 @default.
• W4306382104 hasConcept C86803240 @default.
• W4306382104 hasConceptScore W4306382104C104317684 @default.
• W4306382104 hasConceptScore W4306382104C134018914 @default.
• W4306382104 hasConceptScore W4306382104C150194340 @default.
• W4306382104 hasConceptScore W4306382104C162317418 @default.
• W4306382104 hasConceptScore W4306382104C165864922 @default.
• W4306382104 hasConceptScore W4306382104C190727270 @default.
• W4306382104 hasConceptScore W4306382104C2776541429 @default.
• W4306382104 hasConceptScore W4306382104C33288867 @default.
• W4306382104 hasConceptScore W4306382104C41091548 @default.
• W4306382104 hasConceptScore W4306382104C54355233 @default.
• W4306382104 hasConceptScore W4306382104C86803240 @default.
• W4306382104 hasLocation W43063821041 @default.
• W4306382104 hasLocation W43063821042 @default.
• W4306382104 hasLocation W43063821043 @default.
• W4306382104 hasOpenAccess W4306382104 @default.
• W4306382104 hasPrimaryLocation W43063821041 @default.
• W4306382104 hasRelatedWork W2046964473 @default.

• next