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- W4306385744 abstract "Interferons (IFNs) bind to cell surface receptors and activate the expression of interferon-stimulated genes (ISGs) through intracellular signaling cascades. ISGs and their expression products have various biological functions, such as antiviral and immunomodulatory effects, and are essential effector molecules for IFN function. ISGs limit the invasion and replication of the virus in a cell-specific and region-specific manner in the central nervous system (CNS). In addition to participating in natural immunity against viral infections, studies have shown that ISGs are essential in the pathogenesis of CNS disorders such as neuroinflammation and neurodegenerative diseases. The aim of this review is to present a macroscopic overview of the characteristics of ISGs that restrict viral neural invasion and the expression of the ISGs underlying viral infection of CNS cells. Furthermore, we elucidate the characteristics of ISGs expression in neurological inflammation, neuropsychiatric disorders such as depression as well as neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). Finally, we summarize several ISGs (ISG15, IFIT2, IFITM3) that have been studied more in recent years for their antiviral infection in the CNS and their research progress in neurological diseases." @default.
- W4306385744 created "2022-10-17" @default.
- W4306385744 creator A5001630289 @default.
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- W4306385744 creator A5077764638 @default.
- W4306385744 creator A5090971703 @default.
- W4306385744 date "2022-10-17" @default.
- W4306385744 modified "2023-10-14" @default.
- W4306385744 title "Expression and mechanisms of interferon-stimulated genes in viral infection of the central nervous system (CNS) and neurological diseases" @default.
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