Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306386302> ?p ?o ?g. }
- W4306386302 endingPage "121090" @default.
- W4306386302 startingPage "121090" @default.
- W4306386302 abstract "Fractures are the result of fragile bone structures after trauma caused by direct or indirect external impact or strong muscular contraction. Most fracture patients undergo surgical fixation to accelerate the healing process and restore the function of mutilated bone. Promoting the healing process remains an important issue for the treatment of bone fractures. Our previous studies demonstrated the remarkable bone-protective effects of kefir peptides (KPs) in ovariectomized rats and mice. In this study, we further evaluate the efficacy of KPs on fracture healing using a rat model of femoral fracture. Fifteen 8-week-old male Sprague Dawley (SD) rats were divided into the sham, mock, and KPs groups, in which the mock and the KPs groups underwent femur-fracture surgery with nail fixation, while the sham group underwent a sham operation. The next day, rats were orally administered with daily 400 mg/kg of KPs (KPs group) or distilled water (sham and mock groups) for four weeks. X-ray imaging, histochemical staining and serum osteogenic markers were applied for fracture healing evaluation. In vitro, mouse bone marrow mesenchymal stem cells (BMMSCs) and MC3T3-E1 line were subjected to osteoblast differentiation in the presence of KPs and compared with no KPs treatment. The results demonstrated that KPs treatment improved the progression of the fracture healing process (p < 0.05) and significantly increased the expressions of Col1a1, Alp, Spp1, Vegfa and Cox2 mRNA in the femurs of the KPs-treated fractured rats compared to those of the mock-treated fracture rats. In vitro, KPs treatment promoted bone regeneration factor (Col1a1, Alp, M-csf and Phospho1) expression in MC3T3-E1-derived osteoblast cultures (on Day 3) and enhanced osteogenic differentiation and mineralization in BMMSC-derived osteoblast cultures (on Day 17 and Day 21). This is the first study to show that KPs can help with fracture healing by promoting osteogenic differentiation, and it also suggests that KPs can be used as a nutritional supplement to accelerate fracture healing." @default.
- W4306386302 created "2022-10-17" @default.
- W4306386302 creator A5008328625 @default.
- W4306386302 creator A5013503671 @default.
- W4306386302 creator A5024074809 @default.
- W4306386302 creator A5025996479 @default.
- W4306386302 creator A5035107736 @default.
- W4306386302 creator A5038616054 @default.
- W4306386302 creator A5065910530 @default.
- W4306386302 creator A5083510599 @default.
- W4306386302 creator A5087489224 @default.
- W4306386302 date "2022-12-01" @default.
- W4306386302 modified "2023-10-01" @default.
- W4306386302 title "Kefir peptides promote osteogenic differentiation to enhance bone fracture healing in rats" @default.
- W4306386302 cites W111042660 @default.
- W4306386302 cites W1510440645 @default.
- W4306386302 cites W1568324637 @default.
- W4306386302 cites W197424539 @default.
- W4306386302 cites W1974271416 @default.
- W4306386302 cites W2001016466 @default.
- W4306386302 cites W2010414844 @default.
- W4306386302 cites W2012764005 @default.
- W4306386302 cites W2034569221 @default.
- W4306386302 cites W2036557984 @default.
- W4306386302 cites W2049357990 @default.
- W4306386302 cites W2052247547 @default.
- W4306386302 cites W2053296436 @default.
- W4306386302 cites W2058642230 @default.
- W4306386302 cites W2059577818 @default.
- W4306386302 cites W2060416200 @default.
- W4306386302 cites W2068803604 @default.
- W4306386302 cites W2069668213 @default.
- W4306386302 cites W2076020535 @default.
- W4306386302 cites W2126754939 @default.
- W4306386302 cites W2138889138 @default.
- W4306386302 cites W2164898914 @default.
- W4306386302 cites W2168789685 @default.
- W4306386302 cites W2169887586 @default.
- W4306386302 cites W2192920945 @default.
- W4306386302 cites W2416710258 @default.
- W4306386302 cites W2565847609 @default.
- W4306386302 cites W2725056820 @default.
- W4306386302 cites W2749443843 @default.
- W4306386302 cites W2804139130 @default.
- W4306386302 cites W2805385615 @default.
- W4306386302 cites W2967431215 @default.
- W4306386302 cites W2981314017 @default.
- W4306386302 cites W3090396328 @default.
- W4306386302 cites W3102834925 @default.
- W4306386302 cites W3147614098 @default.
- W4306386302 cites W3174414492 @default.
- W4306386302 cites W3195195170 @default.
- W4306386302 cites W3213765342 @default.
- W4306386302 cites W4213005850 @default.
- W4306386302 cites W4236708194 @default.
- W4306386302 cites W4242572842 @default.
- W4306386302 cites W4281775653 @default.
- W4306386302 doi "https://doi.org/10.1016/j.lfs.2022.121090" @default.
- W4306386302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36257457" @default.
- W4306386302 hasPublicationYear "2022" @default.
- W4306386302 type Work @default.
- W4306386302 citedByCount "1" @default.
- W4306386302 countsByYear W43063863022023 @default.
- W4306386302 crossrefType "journal-article" @default.
- W4306386302 hasAuthorship W4306386302A5008328625 @default.
- W4306386302 hasAuthorship W4306386302A5013503671 @default.
- W4306386302 hasAuthorship W4306386302A5024074809 @default.
- W4306386302 hasAuthorship W4306386302A5025996479 @default.
- W4306386302 hasAuthorship W4306386302A5035107736 @default.
- W4306386302 hasAuthorship W4306386302A5038616054 @default.
- W4306386302 hasAuthorship W4306386302A5065910530 @default.
- W4306386302 hasAuthorship W4306386302A5083510599 @default.
- W4306386302 hasAuthorship W4306386302A5087489224 @default.
- W4306386302 hasBestOaLocation W43063863021 @default.
- W4306386302 hasConcept C126322002 @default.
- W4306386302 hasConcept C126838900 @default.
- W4306386302 hasConcept C134018914 @default.
- W4306386302 hasConcept C141071460 @default.
- W4306386302 hasConcept C142724271 @default.
- W4306386302 hasConcept C146249460 @default.
- W4306386302 hasConcept C185592680 @default.
- W4306386302 hasConcept C198826908 @default.
- W4306386302 hasConcept C202751555 @default.
- W4306386302 hasConcept C2776441800 @default.
- W4306386302 hasConcept C2777164284 @default.
- W4306386302 hasConcept C2778260815 @default.
- W4306386302 hasConcept C2780007613 @default.
- W4306386302 hasConcept C2780012534 @default.
- W4306386302 hasConcept C2780554211 @default.
- W4306386302 hasConcept C2908647359 @default.
- W4306386302 hasConcept C55493867 @default.
- W4306386302 hasConcept C71924100 @default.
- W4306386302 hasConcept C8264082 @default.
- W4306386302 hasConcept C8337478 @default.
- W4306386302 hasConcept C99454951 @default.
- W4306386302 hasConceptScore W4306386302C126322002 @default.
- W4306386302 hasConceptScore W4306386302C126838900 @default.
- W4306386302 hasConceptScore W4306386302C134018914 @default.