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• W4306391370 endingPage "1719" @default.
• W4306391370 startingPage "1719" @default.
• W4306391370 abstract "Reward Deficiency Syndrome (RDS) is defined as a breakdown of reward neurotransmission that results in a wide range of addictive, compulsive, and impulsive behaviors. RDS is caused by a combination of environmental (epigenetic) influences and DNA-based (genetic) neurotransmission deficits that interfere with the normal satisfaction of human physiological drives (i.e., food, water, and sex). An essential feature of RDS is the lack of integration between perception, cognition, and emotions that occurs because of (1) significant dopaminergic surges in motivation, reward, and learning centers causing neuroplasticity in the striato-thalamic-frontal cortical loop; (2) hypo-functionality of the excitatory glutamatergic afferents from the amygdala-hippocampus complex. A large volume of literature regarding the known neurogenetic and psychological underpinnings of RDS has revealed a significant risk of dopaminergic gene polymorphic allele overlap between cohorts of depression and subsets of schizophrenia. The suggestion is that instead of alcohol, opioids, gambling disorders, etc. being endophenotypes, the true phenotype is RDS. Additionally, reward deficiency can result from depleted or hereditary hypodopaminergia, which can manifest as a variety of personality traits and mental/medical disorders that have been linked to genetic studies with dopamine-depleting alleles. The carrying of known DNA antecedents, including epigenetic insults, results in a life-long vulnerability to RDS conditions and addictive behaviors. Epigenetic repair of hypodopaminergia, the causative basis of addictive behaviors, may involve precision DNA-guided therapy achieved by combining the Genetic Addiction Risk Severity (GARS) test with a researched neutraceutical having a number of variant names, including KB220Z. This nutraceutical formulation with pro-dopamine regulatory capabilities has been studied and published in peer-reviewed journals, mostly from our laboratory. Finally, it is our opinion that RDS should be given an ICD code and deserves to be included in the DSM-VI because while the DSM features symptomology, it is equally important to feature etiological roots as portrayed in the RDS model." @default.
• W4306391370 created "2022-10-17" @default.
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• W4306391370 date "2022-10-14" @default.
• W4306391370 modified "2023-10-14" @default.
• W4306391370 title "Should Reward Deficiency Syndrome (RDS) Be Considered an Umbrella Disorder for Mental Illness and Associated Genetic and Epigenetic Induced Dysregulation of Brain Reward Circuitry?" @default.
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• W4306391370 cites W1924190890 @default.
• W4306391370 cites W1983177153 @default.
• W4306391370 cites W1987488180 @default.
• W4306391370 cites W1997159235 @default.
• W4306391370 cites W2000512982 @default.
• W4306391370 cites W2023373692 @default.
• W4306391370 cites W2028561938 @default.
• W4306391370 cites W2041667502 @default.
• W4306391370 cites W2045462862 @default.
• W4306391370 cites W2045766361 @default.
• W4306391370 cites W2050084080 @default.
• W4306391370 cites W2065841438 @default.
• W4306391370 cites W2077529325 @default.
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• W4306391370 cites W2080079285 @default.
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• W4306391370 cites W2088829922 @default.
• W4306391370 cites W2090038734 @default.
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• W4306391370 cites W2113949363 @default.
• W4306391370 cites W2115207541 @default.
• W4306391370 cites W2116138658 @default.
• W4306391370 cites W2116754256 @default.
• W4306391370 cites W2136246479 @default.
• W4306391370 cites W2144747578 @default.
• W4306391370 cites W2165520785 @default.
• W4306391370 cites W2228504785 @default.
• W4306391370 cites W2290789544 @default.
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• W4306391370 cites W2413791982 @default.
• W4306391370 cites W2514984695 @default.
• W4306391370 cites W2545618671 @default.
• W4306391370 cites W2548433084 @default.
• W4306391370 cites W2561646545 @default.
• W4306391370 cites W2588924122 @default.
• W4306391370 cites W2598561210 @default.
• W4306391370 cites W2608331258 @default.
• W4306391370 cites W2789447644 @default.
• W4306391370 cites W2790368363 @default.
• W4306391370 cites W2898489445 @default.
• W4306391370 cites W2899605630 @default.
• W4306391370 cites W2980983796 @default.
• W4306391370 cites W2984836846 @default.
• W4306391370 cites W2994708861 @default.
• W4306391370 cites W3005772501 @default.
• W4306391370 cites W3010621841 @default.
• W4306391370 cites W3023186816 @default.
• W4306391370 cites W3029080535 @default.
• W4306391370 cites W3039053277 @default.
• W4306391370 cites W3087165214 @default.
• W4306391370 cites W3117348217 @default.
• W4306391370 cites W3119401745 @default.
• W4306391370 cites W3130498772 @default.
• W4306391370 cites W3130511887 @default.
• W4306391370 cites W3134734702 @default.
• W4306391370 cites W3160286893 @default.
• W4306391370 cites W3164229919 @default.
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• W4306391370 cites W3216034796 @default.
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• W4306391370 cites W4210603432 @default.
• W4306391370 cites W4213328214 @default.
• W4306391370 cites W4223456543 @default.
• W4306391370 cites W4225014735 @default.
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• W4306391370 doi "https://doi.org/10.3390/jpm12101719" @default.
• W4306391370 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36294858" @default.
• W4306391370 hasPublicationYear "2022" @default.
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