FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306392728> ?p ?o ?g. }

• W4306392728 abstract "N-terminal Cys modification has been intensively studied to produce homogeneous bioconjugates essentially through two modes of reaction: reversible modification with the equilibrium shifted towards the formation of the desired conjugate or stable and irreversible conjugates. Herein, we report a new method of N-terminal cysteine modification using O-salicylaldehyde esters (OSAEs) through fast conjugation and irreversible deconjugation. These reagents can rapidly react with N-terminal Cys at low-micromolar concentration to form thiazolidines with subsequent hydrolysis of the ester moiety to the phenolic derivative. These phenolic thiazolidines can be hydrolyzed at acidic pH (≈4.5) to recover the intact N-terminal Cys. Bioconjugation reactions using OSAEs offer controlled reversibility to as act as a protecting group for N-terminal cysteines, allowing the modification of in-chain residues without perturbing the N-terminal Cys, which can then be deprotected and used as a conjugation site." @default.
• W4306392728 created "2022-10-17" @default.
• W4306392728 creator A5008477228 @default.
• W4306392728 creator A5046772276 @default.
• W4306392728 creator A5051569257 @default.
• W4306392728 creator A5053461180 @default.
• W4306392728 creator A5088300536 @default.
• W4306392728 date "2022-11-14" @default.
• W4306392728 modified "2023-10-15" @default.
• W4306392728 title "Interactive Bioconjugation at <i>N</i> ‐Terminal Cysteines by Using <i>O</i> ‐Salicylaldehyde Esters towards Dual Site‐Selective Functionalization" @default.
• W4306392728 cites W1969337165 @default.
• W4306392728 cites W1989297441 @default.
• W4306392728 cites W2254963963 @default.
• W4306392728 cites W2295408967 @default.
• W4306392728 cites W2333026048 @default.
• W4306392728 cites W2415807678 @default.
• W4306392728 cites W2428986104 @default.
• W4306392728 cites W2517960934 @default.
• W4306392728 cites W2670390373 @default.
• W4306392728 cites W2835434808 @default.
• W4306392728 cites W2883423514 @default.
• W4306392728 cites W2896887488 @default.
• W4306392728 cites W2897358702 @default.
• W4306392728 cites W2917912064 @default.
• W4306392728 cites W2979996461 @default.
• W4306392728 cites W2998934264 @default.
• W4306392728 cites W3008519780 @default.
• W4306392728 cites W3008740529 @default.
• W4306392728 cites W3028245233 @default.
• W4306392728 cites W3042135147 @default.
• W4306392728 cites W3124005408 @default.
• W4306392728 cites W3168245075 @default.
• W4306392728 cites W3172353681 @default.
• W4306392728 cites W3194866316 @default.
• W4306392728 cites W4234076445 @default.
• W4306392728 cites W4281719761 @default.
• W4306392728 cites W4306392728 @default.
• W4306392728 doi "https://doi.org/10.1002/chem.202202377" @default.
• W4306392728 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36245264" @default.
• W4306392728 hasPublicationYear "2022" @default.
• W4306392728 type Work @default.
• W4306392728 citedByCount "4" @default.
• W4306392728 countsByYear W43063927282022 @default.
• W4306392728 countsByYear W43063927282023 @default.
• W4306392728 crossrefType "journal-article" @default.
• W4306392728 hasAuthorship W4306392728A5008477228 @default.
• W4306392728 hasAuthorship W4306392728A5046772276 @default.
• W4306392728 hasAuthorship W4306392728A5051569257 @default.
• W4306392728 hasAuthorship W4306392728A5053461180 @default.
• W4306392728 hasAuthorship W4306392728A5088300536 @default.
• W4306392728 hasBestOaLocation W43063927281 @default.
• W4306392728 hasConcept C106159729 @default.
• W4306392728 hasConcept C111771559 @default.
• W4306392728 hasConcept C115537861 @default.
• W4306392728 hasConcept C134306372 @default.
• W4306392728 hasConcept C147789679 @default.
• W4306392728 hasConcept C162324750 @default.
• W4306392728 hasConcept C178790620 @default.
• W4306392728 hasConcept C180577832 @default.
• W4306392728 hasConcept C181199279 @default.
• W4306392728 hasConcept C184133267 @default.
• W4306392728 hasConcept C185592680 @default.
• W4306392728 hasConcept C188027245 @default.
• W4306392728 hasConcept C197336794 @default.
• W4306392728 hasConcept C21951064 @default.
• W4306392728 hasConcept C23963754 @default.
• W4306392728 hasConcept C2776428424 @default.
• W4306392728 hasConcept C2776568683 @default.
• W4306392728 hasConcept C2779201268 @default.
• W4306392728 hasConcept C2779256853 @default.
• W4306392728 hasConcept C2779664074 @default.
• W4306392728 hasConcept C33923547 @default.
• W4306392728 hasConcept C40875361 @default.
• W4306392728 hasConcept C41008148 @default.
• W4306392728 hasConcept C71240020 @default.
• W4306392728 hasConcept C76155785 @default.
• W4306392728 hasConcept C94412978 @default.
• W4306392728 hasConceptScore W4306392728C106159729 @default.
• W4306392728 hasConceptScore W4306392728C111771559 @default.
• W4306392728 hasConceptScore W4306392728C115537861 @default.
• W4306392728 hasConceptScore W4306392728C134306372 @default.
• W4306392728 hasConceptScore W4306392728C147789679 @default.
• W4306392728 hasConceptScore W4306392728C162324750 @default.
• W4306392728 hasConceptScore W4306392728C178790620 @default.
• W4306392728 hasConceptScore W4306392728C180577832 @default.
• W4306392728 hasConceptScore W4306392728C181199279 @default.
• W4306392728 hasConceptScore W4306392728C184133267 @default.
• W4306392728 hasConceptScore W4306392728C185592680 @default.
• W4306392728 hasConceptScore W4306392728C188027245 @default.
• W4306392728 hasConceptScore W4306392728C197336794 @default.
• W4306392728 hasConceptScore W4306392728C21951064 @default.
• W4306392728 hasConceptScore W4306392728C23963754 @default.
• W4306392728 hasConceptScore W4306392728C2776428424 @default.
• W4306392728 hasConceptScore W4306392728C2776568683 @default.
• W4306392728 hasConceptScore W4306392728C2779201268 @default.
• W4306392728 hasConceptScore W4306392728C2779256853 @default.
• W4306392728 hasConceptScore W4306392728C2779664074 @default.
• W4306392728 hasConceptScore W4306392728C33923547 @default.
• W4306392728 hasConceptScore W4306392728C40875361 @default.
• W4306392728 hasConceptScore W4306392728C41008148 @default.

• next