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- W4306398802 abstract "Long-term high fructose intake drives oxidative stress, causing glomerular podocyte injury. Polydatin, isolated from Chinese herbal medicine Polygonum cuspidatum, is used as an antioxidant agent that protects kidney function. However, it remains unclear how polydatin prevents oxidative stress-driven podocyte damage. In this study, polydatin attenuated high fructose-induced high expression of HIF-1α, inhibited NOX4-mediated stromal cell-derived factor-1α/C-X-C chemokine receptor type 4 (SDF-1α/CXCR4) axis activation, reduced reactive oxygen species (ROS) production in rat glomeruli and cultured podocytes. As a result, polydatin up-regulated nephrin and podocin, down-regulated transient receptor potential cation channel 6 (TRPC6) in these animal and cell models. Moreover, the data from HIF-1α siRNA transfection showed that high fructose increased NOX4 expression and aggravated SDF-1α/CXCR4 axis activation in an HIF-1α-dependent manner, whereas polydatin down-regulated HIF-1α to inhibit NOX4 and suppressed SDF-1α/CXCR4 axis activation, ameliorating high fructose-induced podocyte oxidative stress and injury. These findings demonstrated that high fructose-driven HIF-1α/NOX4 pathway controlled podocyte oxidative stress damage. Intervention of this disturbance by polydatin could help the development of the therapeutic strategy to combat podocyte damage associated with high fructose diet." @default.
- W4306398802 created "2022-10-17" @default.
- W4306398802 creator A5019994019 @default.
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- W4306398802 creator A5082839498 @default.
- W4306398802 creator A5088201472 @default.
- W4306398802 date "2022-10-16" @default.
- W4306398802 modified "2023-10-17" @default.
- W4306398802 title "Polydatin Ameliorates High Fructose-Induced Podocyte Oxidative Stress via Suppressing HIF-1α/NOX4 Pathway" @default.
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- W4306398802 doi "https://doi.org/10.3390/pharmaceutics14102202" @default.
- W4306398802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36297636" @default.
- W4306398802 hasPublicationYear "2022" @default.
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