FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306398895> ?p ?o ?g. }

• W4306398895 abstract "Acquired resistance to osimertinib is inevitable and heterogeneous despite its documented efficacy against EGFR-mutated non-small cell lung cancer (NSCLC). Subsequent therapeutic options assume the dominant form of the resistance mechanism; however, the more rare oncogenic driver, NTRK1 fusion, has also reportedly conferred osimertinib resistance. Nevertheless, clear-cut options when NSCLCs are driven by EGFR mutation and the subsequent NTRK fusion are lacking. This is a case of NSCLC wherein exon 19 deletion in EGFR (19del) and acquired LMNA-NTRK1 fusion were accompanied by the persistence of EGFR T790M. The patient underwent peritoneal metastasis after multiple targeted therapies: gefitinib, osimertinib, chemotherapy, and anlotinib plus docetaxel (in clinical trials). Osimertinib was subsequently re-administered with the NTRK fusion inhibitor entrectinib, resulting in remission of peritoneal metastases even after slow progression of pancreatic metastasis over the following 5 months. An extensive literature review to identify the efficacies of therapies for NTRK fusion as the means to acquired resistance to EGFR TKIs revealed that blocking both the EGFR mutation and the subsequent NTRK fusion can provide clinical benefits following EGFR TKIs resistance; however, the efficacy and safety of combination therapies must be further investigated. To precisely manage EGFR-mutated NSCLCs, it is also essential to identify the resistance mechanisms by repeating biopsies." @default.
• W4306398895 created "2022-10-17" @default.
• W4306398895 creator A5014483694 @default.
• W4306398895 creator A5023017024 @default.
• W4306398895 creator A5031927680 @default.
• W4306398895 creator A5052304130 @default.
• W4306398895 creator A5059296721 @default.
• W4306398895 creator A5078783548 @default.
• W4306398895 date "2022-10-17" @default.
• W4306398895 modified "2023-10-17" @default.
• W4306398895 title "Survival benefit of combinatorial osimertinib rechallenge and entrectinib in an <scp>EGFR</scp>‐mutant <scp>NSCLC</scp> patient with acquired <scp>LMNA‐NTRK1</scp> fusion following osimertinib resistance" @default.
• W4306398895 cites W1975784282 @default.
• W4306398895 cites W2259419843 @default.
• W4306398895 cites W2560717039 @default.
• W4306398895 cites W2770828094 @default.
• W4306398895 cites W2784371446 @default.
• W4306398895 cites W2790254562 @default.
• W4306398895 cites W2805346544 @default.
• W4306398895 cites W2809120579 @default.
• W4306398895 cites W2885210084 @default.
• W4306398895 cites W2885289995 @default.
• W4306398895 cites W2889503014 @default.
• W4306398895 cites W2894066036 @default.
• W4306398895 cites W2898171786 @default.
• W4306398895 cites W2907628865 @default.
• W4306398895 cites W2915437889 @default.
• W4306398895 cites W2925781938 @default.
• W4306398895 cites W2931648851 @default.
• W4306398895 cites W2976640752 @default.
• W4306398895 cites W2982467384 @default.
• W4306398895 cites W2995220921 @default.
• W4306398895 cites W2996574710 @default.
• W4306398895 cites W2999801017 @default.
• W4306398895 cites W3008107700 @default.
• W4306398895 cites W3016720073 @default.
• W4306398895 cites W3096837883 @default.
• W4306398895 cites W3110682386 @default.
• W4306398895 cites W3119005666 @default.
• W4306398895 cites W3120351897 @default.
• W4306398895 cites W3121410155 @default.
• W4306398895 cites W3121714975 @default.
• W4306398895 cites W3138641935 @default.
• W4306398895 cites W3153780968 @default.
• W4306398895 cites W3167219830 @default.
• W4306398895 cites W3176623048 @default.
• W4306398895 cites W3200947479 @default.
• W4306398895 cites W4205405376 @default.
• W4306398895 cites W4206810621 @default.
• W4306398895 cites W4226504665 @default.
• W4306398895 cites W4280533169 @default.
• W4306398895 doi "https://doi.org/10.1002/rcr2.1054" @default.
• W4306398895 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36258694" @default.
• W4306398895 hasPublicationYear "2022" @default.
• W4306398895 type Work @default.
• W4306398895 citedByCount "2" @default.
• W4306398895 countsByYear W43063988952023 @default.
• W4306398895 crossrefType "journal-article" @default.
• W4306398895 hasAuthorship W4306398895A5014483694 @default.
• W4306398895 hasAuthorship W4306398895A5023017024 @default.
• W4306398895 hasAuthorship W4306398895A5031927680 @default.
• W4306398895 hasAuthorship W4306398895A5052304130 @default.
• W4306398895 hasAuthorship W4306398895A5059296721 @default.
• W4306398895 hasAuthorship W4306398895A5078783548 @default.
• W4306398895 hasBestOaLocation W43063988951 @default.
• W4306398895 hasConcept C121608353 @default.
• W4306398895 hasConcept C126322002 @default.
• W4306398895 hasConcept C143998085 @default.
• W4306398895 hasConcept C2775999482 @default.
• W4306398895 hasConcept C2776232967 @default.
• W4306398895 hasConcept C2776256026 @default.
• W4306398895 hasConcept C2777626846 @default.
• W4306398895 hasConcept C2777930144 @default.
• W4306398895 hasConcept C2779422266 @default.
• W4306398895 hasConcept C2779438470 @default.
• W4306398895 hasConcept C2780580887 @default.
• W4306398895 hasConcept C2781182431 @default.
• W4306398895 hasConcept C2781190966 @default.
• W4306398895 hasConcept C502942594 @default.
• W4306398895 hasConcept C71924100 @default.
• W4306398895 hasConceptScore W4306398895C121608353 @default.
• W4306398895 hasConceptScore W4306398895C126322002 @default.
• W4306398895 hasConceptScore W4306398895C143998085 @default.
• W4306398895 hasConceptScore W4306398895C2775999482 @default.
• W4306398895 hasConceptScore W4306398895C2776232967 @default.
• W4306398895 hasConceptScore W4306398895C2776256026 @default.
• W4306398895 hasConceptScore W4306398895C2777626846 @default.
• W4306398895 hasConceptScore W4306398895C2777930144 @default.
• W4306398895 hasConceptScore W4306398895C2779422266 @default.
• W4306398895 hasConceptScore W4306398895C2779438470 @default.
• W4306398895 hasConceptScore W4306398895C2780580887 @default.
• W4306398895 hasConceptScore W4306398895C2781182431 @default.
• W4306398895 hasConceptScore W4306398895C2781190966 @default.
• W4306398895 hasConceptScore W4306398895C502942594 @default.
• W4306398895 hasConceptScore W4306398895C71924100 @default.
• W4306398895 hasFunder F4320321001 @default.
• W4306398895 hasIssue "11" @default.
• W4306398895 hasLocation W43063988951 @default.
• W4306398895 hasLocation W43063988952 @default.
• W4306398895 hasLocation W43063988953 @default.
• W4306398895 hasLocation W43063988954 @default.

• next