Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306408058> ?p ?o ?g. }
- W4306408058 endingPage "37" @default.
- W4306408058 startingPage "23" @default.
- W4306408058 abstract "Trained immunity is a functional state of the innate immune response and is characterized by long-term epigenetic reprogramming of innate immune cells. This concept originated in the field of infectious diseases — training of innate immune cells, such as monocytes, macrophages and/or natural killer cells, by infection or vaccination enhances immune responses against microbial pathogens after restimulation. Although initially reported in circulating monocytes and tissue macrophages (termed peripheral trained immunity), subsequent findings indicate that immune progenitor cells in the bone marrow can also be trained (that is, central trained immunity), which explains the long-term innate immunity-mediated protective effects of vaccination against heterologous infections. Although trained immunity is beneficial against infections, its inappropriate induction by endogenous stimuli can also lead to aberrant inflammation. For example, in systemic lupus erythematosus and systemic sclerosis, trained immunity might contribute to inflammatory activity, which promotes disease progression. In organ transplantation, trained immunity has been associated with acute rejection and suppression of trained immunity prolonged allograft survival. This novel concept provides a better understanding of the involvement of the innate immune response in different pathological conditions, and provides a new framework for the development of therapies and treatment strategies that target epigenetic and metabolic pathways of the innate immune system. Trained immunity refers to the development of immunological memory in innate immune cells. Here, the authors examine the basic features of trained immunity, as well as its role and potential therapeutic targeting in immunopathologies that involve the kidney." @default.
- W4306408058 created "2022-10-17" @default.
- W4306408058 creator A5008616618 @default.
- W4306408058 creator A5053775273 @default.
- W4306408058 creator A5063763204 @default.
- W4306408058 creator A5077664248 @default.
- W4306408058 creator A5084623835 @default.
- W4306408058 date "2022-10-17" @default.
- W4306408058 modified "2023-10-13" @default.
- W4306408058 title "Trained immunity — basic concepts and contributions to immunopathology" @default.
- W4306408058 cites W145549817 @default.
- W4306408058 cites W1520434148 @default.
- W4306408058 cites W1573831036 @default.
- W4306408058 cites W1579566330 @default.
- W4306408058 cites W1586476801 @default.
- W4306408058 cites W1798881623 @default.
- W4306408058 cites W1814713647 @default.
- W4306408058 cites W1873909974 @default.
- W4306408058 cites W1874828689 @default.
- W4306408058 cites W1890269349 @default.
- W4306408058 cites W1913363998 @default.
- W4306408058 cites W1972847358 @default.
- W4306408058 cites W1973404097 @default.
- W4306408058 cites W1975899274 @default.
- W4306408058 cites W1976611543 @default.
- W4306408058 cites W1976884472 @default.
- W4306408058 cites W1976925504 @default.
- W4306408058 cites W1984378291 @default.
- W4306408058 cites W1986612506 @default.
- W4306408058 cites W1992260112 @default.
- W4306408058 cites W1992789370 @default.
- W4306408058 cites W1996845627 @default.
- W4306408058 cites W1996960782 @default.
- W4306408058 cites W1996978408 @default.
- W4306408058 cites W2003820403 @default.
- W4306408058 cites W2003867931 @default.
- W4306408058 cites W2009443236 @default.
- W4306408058 cites W2009800174 @default.
- W4306408058 cites W2018466091 @default.
- W4306408058 cites W2018643167 @default.
- W4306408058 cites W2026576172 @default.
- W4306408058 cites W2027543663 @default.
- W4306408058 cites W2028131879 @default.
- W4306408058 cites W2043371713 @default.
- W4306408058 cites W2044757050 @default.
- W4306408058 cites W2051073305 @default.
- W4306408058 cites W2051328227 @default.
- W4306408058 cites W2051872988 @default.
- W4306408058 cites W2053150221 @default.
- W4306408058 cites W2056739827 @default.
- W4306408058 cites W2057159822 @default.
- W4306408058 cites W2058969608 @default.
- W4306408058 cites W2059403792 @default.
- W4306408058 cites W2062147513 @default.
- W4306408058 cites W2067031028 @default.
- W4306408058 cites W2067507533 @default.
- W4306408058 cites W2067924210 @default.
- W4306408058 cites W2068504803 @default.
- W4306408058 cites W2069917993 @default.
- W4306408058 cites W2072805330 @default.
- W4306408058 cites W2073021729 @default.
- W4306408058 cites W2075420367 @default.
- W4306408058 cites W2079709122 @default.
- W4306408058 cites W2080147816 @default.
- W4306408058 cites W2083159498 @default.
- W4306408058 cites W2083556305 @default.
- W4306408058 cites W2085281378 @default.
- W4306408058 cites W2089162544 @default.
- W4306408058 cites W2100018765 @default.
- W4306408058 cites W2107202424 @default.
- W4306408058 cites W2108373994 @default.
- W4306408058 cites W2108639843 @default.
- W4306408058 cites W2109491705 @default.
- W4306408058 cites W2111443452 @default.
- W4306408058 cites W2114975963 @default.
- W4306408058 cites W2116169915 @default.
- W4306408058 cites W2116797415 @default.
- W4306408058 cites W2117757143 @default.
- W4306408058 cites W2119828139 @default.
- W4306408058 cites W2122136428 @default.
- W4306408058 cites W2123580195 @default.
- W4306408058 cites W2125461612 @default.
- W4306408058 cites W2126924404 @default.
- W4306408058 cites W2127063807 @default.
- W4306408058 cites W2127802406 @default.
- W4306408058 cites W2128337342 @default.
- W4306408058 cites W2129896562 @default.
- W4306408058 cites W2132394487 @default.
- W4306408058 cites W2134862628 @default.
- W4306408058 cites W2140876277 @default.
- W4306408058 cites W2144072179 @default.
- W4306408058 cites W2147406541 @default.
- W4306408058 cites W2150594596 @default.
- W4306408058 cites W2151247869 @default.
- W4306408058 cites W2151823150 @default.
- W4306408058 cites W2155558043 @default.
- W4306408058 cites W2158380859 @default.
- W4306408058 cites W2158667202 @default.