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- W4306411241 endingPage "116280" @default.
- W4306411241 startingPage "116280" @default.
- W4306411241 abstract "Pesticides are toxic and biological substances used for mitigating harmful pests. Their application in agricultural fields and homes increased environmental pollution. Studies showed their harmful effects on human health, specifically children, who are more vulnerable than adults. The International Agency for Research on Cancer (IARC) has introduced several pesticides as carcinogens. This study aims to systematically summarize and review all studies related to pesticides and cancer. This systematic review is based on PRISMA rules. Three central databases were employed to find studies on pesticide exposure and cancer correlation published from 2017 to September 2022. After reviewing several studies, we found that most studies revealed a significant relationship between pesticide exposure and an increased cancer incidence rate. Among the most studied group of pesticides is organochlorine (OC) pesticides. OC pesticides and their residues could significantly increase cancer in children and adults. Mechanistic studies revealed that pesticides could increase the risk of different cancers by genetics, like an increased expression of some genes like p21, p53 or epigenetic impairments. Cell cycle impairments like expanding the G1 to S phase transition are another mechanism of causing cancer. DNA methylation and histone modifications increase the risk of numerous cancers. Based on epidemiological studies, pesticides are a significant concern to human health, specifically cancer development, and should be more restrained. Their most reported mechanism of action were genetic and epigenetic impairments which cause cancers." @default.
- W4306411241 created "2022-10-17" @default.
- W4306411241 creator A5018770850 @default.
- W4306411241 creator A5073860107 @default.
- W4306411241 date "2022-12-01" @default.
- W4306411241 modified "2023-10-11" @default.
- W4306411241 title "A systematic review of mechanistic studies on the relationship between pesticide exposure and cancer induction" @default.
- W4306411241 cites W1969671744 @default.
- W4306411241 cites W2147305349 @default.
- W4306411241 cites W2159372512 @default.
- W4306411241 cites W2161374186 @default.
- W4306411241 cites W2474391438 @default.
- W4306411241 cites W2528418013 @default.
- W4306411241 cites W2546882642 @default.
- W4306411241 cites W2555366770 @default.
- W4306411241 cites W2566478975 @default.
- W4306411241 cites W2568164776 @default.
- W4306411241 cites W2580525894 @default.
- W4306411241 cites W2586054114 @default.
- W4306411241 cites W2588253167 @default.
- W4306411241 cites W2588272821 @default.
- W4306411241 cites W2595598475 @default.
- W4306411241 cites W2611530662 @default.
- W4306411241 cites W2614707158 @default.
- W4306411241 cites W2626587624 @default.
- W4306411241 cites W2626867137 @default.
- W4306411241 cites W2732835126 @default.
- W4306411241 cites W2738577117 @default.
- W4306411241 cites W2740198759 @default.
- W4306411241 cites W2744732861 @default.
- W4306411241 cites W2748891261 @default.
- W4306411241 cites W2751213144 @default.
- W4306411241 cites W2754205729 @default.
- W4306411241 cites W2758731328 @default.
- W4306411241 cites W2764089011 @default.
- W4306411241 cites W2765426709 @default.
- W4306411241 cites W2767139575 @default.
- W4306411241 cites W2767657316 @default.
- W4306411241 cites W2767764959 @default.
- W4306411241 cites W2769815726 @default.
- W4306411241 cites W2788944184 @default.
- W4306411241 cites W2793005189 @default.
- W4306411241 cites W2797303473 @default.
- W4306411241 cites W2799930637 @default.
- W4306411241 cites W2801750553 @default.
- W4306411241 cites W2802050505 @default.
- W4306411241 cites W2802775949 @default.
- W4306411241 cites W2806267591 @default.
- W4306411241 cites W2808231991 @default.
- W4306411241 cites W2808965130 @default.
- W4306411241 cites W2809321908 @default.
- W4306411241 cites W2809384550 @default.
- W4306411241 cites W2883220213 @default.
- W4306411241 cites W2883610143 @default.
- W4306411241 cites W2889414204 @default.
- W4306411241 cites W2889827834 @default.
- W4306411241 cites W2891625517 @default.
- W4306411241 cites W2895305196 @default.
- W4306411241 cites W2896150921 @default.
- W4306411241 cites W2896560468 @default.
- W4306411241 cites W2900974273 @default.
- W4306411241 cites W2903800089 @default.
- W4306411241 cites W2913620103 @default.
- W4306411241 cites W2913664547 @default.
- W4306411241 cites W2915063273 @default.
- W4306411241 cites W2924004199 @default.
- W4306411241 cites W2925277406 @default.
- W4306411241 cites W2929417470 @default.
- W4306411241 cites W2938865112 @default.
- W4306411241 cites W2940564983 @default.
- W4306411241 cites W2943124283 @default.
- W4306411241 cites W2943939145 @default.
- W4306411241 cites W2944178106 @default.
- W4306411241 cites W2947051991 @default.
- W4306411241 cites W2947205765 @default.
- W4306411241 cites W2951973012 @default.
- W4306411241 cites W2958335281 @default.
- W4306411241 cites W2960415539 @default.
- W4306411241 cites W2963633640 @default.
- W4306411241 cites W2963799360 @default.
- W4306411241 cites W2964245196 @default.
- W4306411241 cites W2964654300 @default.
- W4306411241 cites W2967388225 @default.
- W4306411241 cites W2971436984 @default.
- W4306411241 cites W2971493854 @default.
- W4306411241 cites W2974051163 @default.
- W4306411241 cites W2974680009 @default.
- W4306411241 cites W2975087603 @default.
- W4306411241 cites W2978170145 @default.
- W4306411241 cites W2978773889 @default.
- W4306411241 cites W2980820480 @default.
- W4306411241 cites W2981006039 @default.
- W4306411241 cites W2982194790 @default.
- W4306411241 cites W2987469986 @default.
- W4306411241 cites W2987756849 @default.
- W4306411241 cites W2988854847 @default.
- W4306411241 cites W2997540594 @default.
- W4306411241 cites W2997833519 @default.