FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306412572> ?p ?o ?g. }

• W4306412572 endingPage "109299" @default.
• W4306412572 startingPage "109299" @default.
• W4306412572 abstract "During the Rituximab era, high dose intravenous methotrexate (HD) and intrathecal methotrexate (IT) are recommended prophylaxis in preventing central nervous system (CNS) relapse of diffuse large B-cell lymphoma (DLBCL) patients. However, the optimal CNS prophylaxis strategies remained uncertain. This meta-analysis research explored the findings of previous studies and highlighted the efficacy of HD and/or IT on CNS prophylaxis of DLBCL patients at intermediate to high risk. Specifically, it aims to answer the following research questions: (1) Is there a difference on CNS relapse rate between HD and IT cohorts? (2) Is there a correlation between CNS prophylaxis and survival? This meta-analysis research performed an in-depth examination of pertinent studies available in PubMed, Embase, and Cochrane databases. The primary endpoints included: CNS relapse rate and 2-year or 3-year survival rate. The findings of the qualified studies were reviewed and analyzed using 5.3 version of the Review Manager software. After thorough analysis of 12 studies involving 5950 DLBCL patients, it was revealed that in comparison with IT alone, HD with or without additional IT (HD ± IT) significantly reduced the risk of CNS relapse (Risk Ratio (RR)= 0.41, 95 % CI (0.24-0.68), P = 0.0007). Besides, the efficacy of HD alone was comparable to HD + IT (RR = 1.08, 95 % CI (0.19-6.32), P = 0.93), which was also considered to be more optimal than IT alone on CNS prophylaxis (RR = 0.39, 95 % CI (0.15-1.06), P = 0.06).Based on these results, IT alone or no-prophylaxis were viewed as a group of inadequate prophylaxis. Comparing to HD ± IT, the 3-year survival rate of inadequate prophylaxis group was lower (RR = 1.17, 95 % CI (1.03-1.32), P = 0.01). The results of this study reveals that in the Rituximab Era, prophylaxis strategies containing HD is better than IT alone or no-prophylaxis on preventing CNS relapse of DLBCL patients with intermediate to high risk." @default.
• W4306412572 created "2022-10-17" @default.
• W4306412572 creator A5013347594 @default.
• W4306412572 creator A5014268203 @default.
• W4306412572 creator A5043824848 @default.
• W4306412572 creator A5045957567 @default.
• W4306412572 creator A5061801481 @default.
• W4306412572 creator A5090815103 @default.
• W4306412572 date "2022-12-01" @default.
• W4306412572 modified "2023-09-26" @default.
• W4306412572 title "Prophylaxis strategies containing high dose intravenous methotrexate on preventing CNS relapse for patients with diffuse large B-cell lymphoma at intermediate to high risk: A study based on 12 cohorts in the rituximab era" @default.
• W4306412572 cites W2018071905 @default.
• W4306412572 cites W2018708925 @default.
• W4306412572 cites W2052011631 @default.
• W4306412572 cites W2057942347 @default.
• W4306412572 cites W2072228041 @default.
• W4306412572 cites W2100885061 @default.
• W4306412572 cites W2115845791 @default.
• W4306412572 cites W2142991507 @default.
• W4306412572 cites W2154868392 @default.
• W4306412572 cites W2310716991 @default.
• W4306412572 cites W2662929969 @default.
• W4306412572 cites W2734666624 @default.
• W4306412572 cites W2740331593 @default.
• W4306412572 cites W2944839297 @default.
• W4306412572 cites W2953052900 @default.
• W4306412572 cites W3037127281 @default.
• W4306412572 cites W3047361396 @default.
• W4306412572 cites W3146194150 @default.
• W4306412572 cites W3151335737 @default.
• W4306412572 cites W3154920207 @default.
• W4306412572 cites W3173034811 @default.
• W4306412572 cites W3188520970 @default.
• W4306412572 cites W3201743266 @default.
• W4306412572 cites W3211838148 @default.
• W4306412572 cites W3212609199 @default.
• W4306412572 cites W3216341107 @default.
• W4306412572 cites W4205858886 @default.
• W4306412572 cites W4206925436 @default.
• W4306412572 doi "https://doi.org/10.1016/j.intimp.2022.109299" @default.
• W4306412572 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36252471" @default.
• W4306412572 hasPublicationYear "2022" @default.
• W4306412572 type Work @default.
• W4306412572 citedByCount "0" @default.
• W4306412572 crossrefType "journal-article" @default.
• W4306412572 hasAuthorship W4306412572A5013347594 @default.
• W4306412572 hasAuthorship W4306412572A5014268203 @default.
• W4306412572 hasAuthorship W4306412572A5043824848 @default.
• W4306412572 hasAuthorship W4306412572A5045957567 @default.
• W4306412572 hasAuthorship W4306412572A5061801481 @default.
• W4306412572 hasAuthorship W4306412572A5090815103 @default.
• W4306412572 hasConcept C126322002 @default.
• W4306412572 hasConcept C143998085 @default.
• W4306412572 hasConcept C2778559949 @default.
• W4306412572 hasConcept C2779338263 @default.
• W4306412572 hasConcept C2780653079 @default.
• W4306412572 hasConcept C2781059491 @default.
• W4306412572 hasConcept C2781173314 @default.
• W4306412572 hasConcept C44249647 @default.
• W4306412572 hasConcept C71924100 @default.
• W4306412572 hasConcept C82789193 @default.
• W4306412572 hasConcept C95190672 @default.
• W4306412572 hasConceptScore W4306412572C126322002 @default.
• W4306412572 hasConceptScore W4306412572C143998085 @default.
• W4306412572 hasConceptScore W4306412572C2778559949 @default.
• W4306412572 hasConceptScore W4306412572C2779338263 @default.
• W4306412572 hasConceptScore W4306412572C2780653079 @default.
• W4306412572 hasConceptScore W4306412572C2781059491 @default.
• W4306412572 hasConceptScore W4306412572C2781173314 @default.
• W4306412572 hasConceptScore W4306412572C44249647 @default.
• W4306412572 hasConceptScore W4306412572C71924100 @default.
• W4306412572 hasConceptScore W4306412572C82789193 @default.
• W4306412572 hasConceptScore W4306412572C95190672 @default.
• W4306412572 hasFunder F4320321001 @default.
• W4306412572 hasLocation W43064125721 @default.
• W4306412572 hasLocation W43064125722 @default.
• W4306412572 hasOpenAccess W4306412572 @default.
• W4306412572 hasPrimaryLocation W43064125721 @default.
• W4306412572 hasRelatedWork W2219644495 @default.
• W4306412572 hasRelatedWork W2318987646 @default.
• W4306412572 hasRelatedWork W2982754619 @default.
• W4306412572 hasRelatedWork W2990044732 @default.
• W4306412572 hasRelatedWork W3024712659 @default.
• W4306412572 hasRelatedWork W3107525433 @default.
• W4306412572 hasRelatedWork W3134284752 @default.
• W4306412572 hasRelatedWork W3191611251 @default.
• W4306412572 hasRelatedWork W4248707236 @default.
• W4306412572 hasRelatedWork W4306412572 @default.
• W4306412572 hasVolume "113" @default.
• W4306412572 isParatext "false" @default.
• W4306412572 isRetracted "false" @default.
• W4306412572 workType "article" @default.