Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306632390> ?p ?o ?g. }
- W4306632390 endingPage "112937" @default.
- W4306632390 startingPage "112937" @default.
- W4306632390 abstract "An ordered nanoporous carbon (ONC) was synthesized by the hard-template method and then superficially modified with amino groups from 3-aminopropyltrietoxisilane (ONC-A). Both carbons, ONC and ONC-A, were characterized and tested as carriers of a high-frequency dosing drug such as cephalexin (CFX). Density functional theory calculations were used to study the interactions between ONC and the amino groups of ONC-A and CFX. Finally, the biocompatibility of human colon carcinoma (Caco-2) cells and in vitro release kinetics at gastric and intestinal pH were evaluated. The results show that drug loading capacity was higher in ONC than in ONC-A, which was associated with a localized increase in adsorption energy and a decrease in the textural properties on the surface of the ONC-A sample. Both carbon materials showed cell viability above 80 %, even at high concentrations (1000 µg mL−1). The CFX release profiles of both carbons reached their maximum at 12 h, whereas the rapid release of pure CFX at gastric and intestinal pH was 30 min. The release mechanisms obeyed the Weibull model governed by Fickian diffusion, influenced by both porosity and functional groups in ONC and ONC-A." @default.
- W4306632390 created "2022-10-18" @default.
- W4306632390 creator A5000386245 @default.
- W4306632390 creator A5004466029 @default.
- W4306632390 creator A5005656173 @default.
- W4306632390 creator A5010948488 @default.
- W4306632390 creator A5021899067 @default.
- W4306632390 creator A5033042201 @default.
- W4306632390 creator A5050716411 @default.
- W4306632390 creator A5062278907 @default.
- W4306632390 creator A5078228330 @default.
- W4306632390 date "2022-12-01" @default.
- W4306632390 modified "2023-10-16" @default.
- W4306632390 title "Biocompatible nanoporous carbons as a carrier system for controlled release of cephalexin" @default.
- W4306632390 cites W1203351676 @default.
- W4306632390 cites W1476726116 @default.
- W4306632390 cites W1978265256 @default.
- W4306632390 cites W1979544533 @default.
- W4306632390 cites W1981368803 @default.
- W4306632390 cites W1981742486 @default.
- W4306632390 cites W2006860810 @default.
- W4306632390 cites W2008114741 @default.
- W4306632390 cites W2022034157 @default.
- W4306632390 cites W2035647309 @default.
- W4306632390 cites W2048670202 @default.
- W4306632390 cites W2088187323 @default.
- W4306632390 cites W2096196478 @default.
- W4306632390 cites W2107513023 @default.
- W4306632390 cites W2160874474 @default.
- W4306632390 cites W2168541124 @default.
- W4306632390 cites W2209413485 @default.
- W4306632390 cites W2253506047 @default.
- W4306632390 cites W2318029900 @default.
- W4306632390 cites W2336089678 @default.
- W4306632390 cites W2535966908 @default.
- W4306632390 cites W2620740824 @default.
- W4306632390 cites W2739145438 @default.
- W4306632390 cites W2750686301 @default.
- W4306632390 cites W2768075519 @default.
- W4306632390 cites W2789358547 @default.
- W4306632390 cites W2791929375 @default.
- W4306632390 cites W2799947210 @default.
- W4306632390 cites W2890167612 @default.
- W4306632390 cites W2912318137 @default.
- W4306632390 cites W2913339275 @default.
- W4306632390 cites W2922918904 @default.
- W4306632390 cites W2939036697 @default.
- W4306632390 cites W2946061808 @default.
- W4306632390 cites W2966668540 @default.
- W4306632390 cites W2973338374 @default.
- W4306632390 cites W2984361855 @default.
- W4306632390 cites W2992292488 @default.
- W4306632390 cites W2998213941 @default.
- W4306632390 cites W3008673236 @default.
- W4306632390 cites W3010480769 @default.
- W4306632390 cites W3013829430 @default.
- W4306632390 cites W3021916112 @default.
- W4306632390 cites W3027161162 @default.
- W4306632390 cites W3050250725 @default.
- W4306632390 cites W3083522063 @default.
- W4306632390 cites W3089028082 @default.
- W4306632390 cites W3138887136 @default.
- W4306632390 cites W3157426475 @default.
- W4306632390 cites W3158371894 @default.
- W4306632390 cites W637146182 @default.
- W4306632390 cites W770915126 @default.
- W4306632390 cites W843007777 @default.
- W4306632390 doi "https://doi.org/10.1016/j.colsurfb.2022.112937" @default.
- W4306632390 hasPublicationYear "2022" @default.
- W4306632390 type Work @default.
- W4306632390 citedByCount "1" @default.
- W4306632390 countsByYear W43066323902023 @default.
- W4306632390 crossrefType "journal-article" @default.
- W4306632390 hasAuthorship W4306632390A5000386245 @default.
- W4306632390 hasAuthorship W4306632390A5004466029 @default.
- W4306632390 hasAuthorship W4306632390A5005656173 @default.
- W4306632390 hasAuthorship W4306632390A5010948488 @default.
- W4306632390 hasAuthorship W4306632390A5021899067 @default.
- W4306632390 hasAuthorship W4306632390A5033042201 @default.
- W4306632390 hasAuthorship W4306632390A5050716411 @default.
- W4306632390 hasAuthorship W4306632390A5062278907 @default.
- W4306632390 hasAuthorship W4306632390A5078228330 @default.
- W4306632390 hasConcept C104779481 @default.
- W4306632390 hasConcept C121332964 @default.
- W4306632390 hasConcept C127413603 @default.
- W4306632390 hasConcept C13245373 @default.
- W4306632390 hasConcept C13965031 @default.
- W4306632390 hasConcept C140205800 @default.
- W4306632390 hasConcept C148898269 @default.
- W4306632390 hasConcept C150394285 @default.
- W4306632390 hasConcept C159985019 @default.
- W4306632390 hasConcept C163588942 @default.
- W4306632390 hasConcept C171250308 @default.
- W4306632390 hasConcept C178790620 @default.
- W4306632390 hasConcept C185592680 @default.
- W4306632390 hasConcept C192562407 @default.
- W4306632390 hasConcept C2777230088 @default.
- W4306632390 hasConcept C2779820397 @default.