FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306641798> ?p ?o ?g. }

• W4306641798 abstract "The alarming rise of multidrug-resistant Gram-positive bacteria has precipitated a healthcare crisis, necessitating the development of new antimicrobial therapies. Here we describe a new class of antibiotics based on a ring-fused 2-pyridone backbone, which are active against vancomycin-resistant enterococci (VRE), a serious threat as classified by the Centers for Disease Control and Prevention, and other multidrug-resistant Gram-positive bacteria. Ring-fused 2-pyridone antibiotics have bacteriostatic activity against actively dividing exponential phase enterococcal cells and bactericidal activity against nondividing stationary phase enterococcal cells. The molecular mechanism of drug-induced killing of stationary phase cells mimics aspects of fratricide observed in enterococcal biofilms, where both are mediated by the Atn autolysin and the GelE protease. In addition, combinations of sublethal concentrations of ring-fused 2-pyridones and standard-of-care antibiotics, such as vancomycin, were found to synergize to kill clinical strains of VRE. Furthermore, a broad range of antibiotic resistant Gram-positive pathogens, including those responsible for the increasing incidence of antibiotic resistant healthcare-associated infections, are susceptible to this new class of 2-pyridone antibiotics. Given the broad antibacterial activities of ring-fused 2-pyridone compounds against Gram-positive (GmP) bacteria we term these compounds GmPcides, which hold promise in combating the rising tide of antibiotic resistant Gram-positive pathogens." @default.
• W4306641798 created "2022-10-18" @default.
• W4306641798 creator A5006919917 @default.
• W4306641798 creator A5012738183 @default.
• W4306641798 creator A5015603057 @default.
• W4306641798 creator A5035728249 @default.
• W4306641798 creator A5040456770 @default.
• W4306641798 creator A5042367226 @default.
• W4306641798 creator A5045156146 @default.
• W4306641798 creator A5045260641 @default.
• W4306641798 creator A5051017654 @default.
• W4306641798 creator A5061646423 @default.
• W4306641798 creator A5064213849 @default.
• W4306641798 creator A5066554041 @default.
• W4306641798 creator A5077172977 @default.
• W4306641798 creator A5081020729 @default.
• W4306641798 date "2022-10-17" @default.
• W4306641798 modified "2023-09-25" @default.
• W4306641798 title "Ring-fused 2-pyridones effective against multidrug-resistant Gram-positive pathogens and synergistic with standard-of-care antibiotics" @default.
• W4306641798 cites W1591477834 @default.
• W4306641798 cites W1975361143 @default.
• W4306641798 cites W1980111518 @default.
• W4306641798 cites W1993320463 @default.
• W4306641798 cites W1996346210 @default.
• W4306641798 cites W2002091468 @default.
• W4306641798 cites W2007422762 @default.
• W4306641798 cites W2009889907 @default.
• W4306641798 cites W2012251902 @default.
• W4306641798 cites W2013926844 @default.
• W4306641798 cites W2030047547 @default.
• W4306641798 cites W2032893012 @default.
• W4306641798 cites W2034979953 @default.
• W4306641798 cites W2045286729 @default.
• W4306641798 cites W2047658961 @default.
• W4306641798 cites W2058952776 @default.
• W4306641798 cites W2065689013 @default.
• W4306641798 cites W2074198759 @default.
• W4306641798 cites W2088726933 @default.
• W4306641798 cites W2092017773 @default.
• W4306641798 cites W2092196558 @default.
• W4306641798 cites W2092523399 @default.
• W4306641798 cites W2103599303 @default.
• W4306641798 cites W2115550568 @default.
• W4306641798 cites W2123610732 @default.
• W4306641798 cites W2127113854 @default.
• W4306641798 cites W2131256712 @default.
• W4306641798 cites W2140642812 @default.
• W4306641798 cites W2142433665 @default.
• W4306641798 cites W2145105787 @default.
• W4306641798 cites W2145271077 @default.
• W4306641798 cites W2151675629 @default.
• W4306641798 cites W2151921983 @default.
• W4306641798 cites W2153668434 @default.
• W4306641798 cites W2153972223 @default.
• W4306641798 cites W2157265409 @default.
• W4306641798 cites W2162260428 @default.
• W4306641798 cites W2167956674 @default.
• W4306641798 cites W2170589482 @default.
• W4306641798 cites W2177643459 @default.
• W4306641798 cites W2312698043 @default.
• W4306641798 cites W2600830049 @default.
• W4306641798 cites W2763098842 @default.
• W4306641798 cites W2766000565 @default.
• W4306641798 cites W2770011032 @default.
• W4306641798 cites W2779199667 @default.
• W4306641798 cites W2795903858 @default.
• W4306641798 cites W2890029298 @default.
• W4306641798 cites W2951329233 @default.
• W4306641798 cites W2951981149 @default.
• W4306641798 cites W2989135569 @default.
• W4306641798 cites W2999736815 @default.
• W4306641798 cites W3022750147 @default.
• W4306641798 cites W3194188670 @default.
• W4306641798 cites W4206677002 @default.
• W4306641798 cites W4210969014 @default.
• W4306641798 cites W4242318543 @default.
• W4306641798 doi "https://doi.org/10.1073/pnas.2210912119" @default.
• W4306641798 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36252016" @default.
• W4306641798 hasPublicationYear "2022" @default.
• W4306641798 type Work @default.
• W4306641798 citedByCount "2" @default.
• W4306641798 countsByYear W43066417982023 @default.
• W4306641798 crossrefType "journal-article" @default.
• W4306641798 hasAuthorship W4306641798A5006919917 @default.
• W4306641798 hasAuthorship W4306641798A5012738183 @default.
• W4306641798 hasAuthorship W4306641798A5015603057 @default.
• W4306641798 hasAuthorship W4306641798A5035728249 @default.
• W4306641798 hasAuthorship W4306641798A5040456770 @default.
• W4306641798 hasAuthorship W4306641798A5042367226 @default.
• W4306641798 hasAuthorship W4306641798A5045156146 @default.
• W4306641798 hasAuthorship W4306641798A5045260641 @default.
• W4306641798 hasAuthorship W4306641798A5051017654 @default.
• W4306641798 hasAuthorship W4306641798A5061646423 @default.
• W4306641798 hasAuthorship W4306641798A5064213849 @default.
• W4306641798 hasAuthorship W4306641798A5066554041 @default.
• W4306641798 hasAuthorship W4306641798A5077172977 @default.
• W4306641798 hasAuthorship W4306641798A5081020729 @default.
• W4306641798 hasBestOaLocation W43066417981 @default.
• W4306641798 hasConcept C133936738 @default.
• W4306641798 hasConcept C2778980435 @default.

• next