FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306642893> ?p ?o ?g. }

• W4306642893 abstract "The distribution of Ly6C/G-positive cells in response to an infection of the mouse respiratory tract with influenza A virus was followed noninvasively over time by immuno-positron emission tomography. We converted nanobodies that recognize Ly6C and Ly6G, markers of neutrophils and other myeloid cells, as well as an influenza hemagglutinin–specific nanobody, into 89 Zr-labeled PEGylated positron emission tomography (PET) imaging agents. The PET images showed strong accumulation of these imaging agents in the lungs of infected mice. Immunohistochemistry of influenza virus–infected mice and control mice, injected with a biotinylated and PEGylated version of the Ly6C/G-specific nanobody, showed the presence of abundant Ly6C/G-positive myeloid cells and positivity for Ly6C/G on bronchial epithelium in influenza virus–infected mice. This is consistent with focal inflammation in the lungs, a finding that correlated well with the immuno-PET results. No such signals were detected in control mice. Having shown by PET the accumulation of the Ly6C/G-specific nanobody in infected lungs, we synthesized conjugates of Ly6C/G-specific nanobodies with dexamethasone to enable targeted delivery of this immunosuppressive corticosteroid to sites of inflammation. Such conjugates reduced the weight loss that accompanies infection, while the equivalent amount of free dexamethasone was without effect. Nanobody-drug conjugates thus enable delivery of drugs to particular cell types at the appropriate anatomic site(s). By avoiding systemic exposure to free dexamethasone, this strategy minimizes its undesirable side effects because of the much lower effective dose of the nanobody-dexamethasone conjugate. The ability to selectively target inflammatory cells may find application in the treatment of other infections or other immune-mediated diseases." @default.
• W4306642893 created "2022-10-18" @default.
• W4306642893 creator A5021687717 @default.
• W4306642893 creator A5031744682 @default.
• W4306642893 creator A5036817329 @default.
• W4306642893 creator A5043764806 @default.
• W4306642893 creator A5049800814 @default.
• W4306642893 creator A5061138417 @default.
• W4306642893 creator A5064951816 @default.
• W4306642893 creator A5081514135 @default.
• W4306642893 creator A5089960696 @default.
• W4306642893 date "2022-10-17" @default.
• W4306642893 modified "2023-10-01" @default.
• W4306642893 title "Targeted delivery of an anti-inflammatory corticosteroid to Ly6C/G-positive cells abates severity of influenza A symptoms" @default.
• W4306642893 cites W1973431219 @default.
• W4306642893 cites W1976549834 @default.
• W4306642893 cites W1979209500 @default.
• W4306642893 cites W1997052774 @default.
• W4306642893 cites W2032636844 @default.
• W4306642893 cites W2037179014 @default.
• W4306642893 cites W2038934200 @default.
• W4306642893 cites W2093389287 @default.
• W4306642893 cites W2166830385 @default.
• W4306642893 cites W2233887337 @default.
• W4306642893 cites W2587710725 @default.
• W4306642893 cites W2733010680 @default.
• W4306642893 cites W2755028013 @default.
• W4306642893 cites W2775123272 @default.
• W4306642893 cites W2810972439 @default.
• W4306642893 cites W2898660562 @default.
• W4306642893 cites W2898721059 @default.
• W4306642893 cites W3004626187 @default.
• W4306642893 cites W3005565657 @default.
• W4306642893 cites W3007742756 @default.
• W4306642893 cites W3016393661 @default.
• W4306642893 cites W3016572511 @default.
• W4306642893 cites W3047139190 @default.
• W4306642893 cites W3082108964 @default.
• W4306642893 cites W3083633589 @default.
• W4306642893 cites W3085242789 @default.
• W4306642893 cites W3092135625 @default.
• W4306642893 cites W3103233549 @default.
• W4306642893 cites W3103789918 @default.
• W4306642893 cites W3134299762 @default.
• W4306642893 cites W3141014958 @default.
• W4306642893 cites W3164161224 @default.
• W4306642893 cites W3171214906 @default.
• W4306642893 cites W3213276455 @default.
• W4306642893 cites W4210642183 @default.
• W4306642893 cites W98831573 @default.
• W4306642893 cites W3193618397 @default.
• W4306642893 doi "https://doi.org/10.1073/pnas.2211065119" @default.
• W4306642893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36252038" @default.
• W4306642893 hasPublicationYear "2022" @default.
• W4306642893 type Work @default.
• W4306642893 citedByCount "2" @default.
• W4306642893 countsByYear W43066428932023 @default.
• W4306642893 crossrefType "journal-article" @default.
• W4306642893 hasAuthorship W4306642893A5021687717 @default.
• W4306642893 hasAuthorship W4306642893A5031744682 @default.
• W4306642893 hasAuthorship W4306642893A5036817329 @default.
• W4306642893 hasAuthorship W4306642893A5043764806 @default.
• W4306642893 hasAuthorship W4306642893A5049800814 @default.
• W4306642893 hasAuthorship W4306642893A5061138417 @default.
• W4306642893 hasAuthorship W4306642893A5064951816 @default.
• W4306642893 hasAuthorship W4306642893A5081514135 @default.
• W4306642893 hasAuthorship W4306642893A5089960696 @default.
• W4306642893 hasBestOaLocation W43066428931 @default.
• W4306642893 hasConcept C126322002 @default.
• W4306642893 hasConcept C142724271 @default.
• W4306642893 hasConcept C159047783 @default.
• W4306642893 hasConcept C203014093 @default.
• W4306642893 hasConcept C2522874641 @default.
• W4306642893 hasConcept C2776914184 @default.
• W4306642893 hasConcept C2777546802 @default.
• W4306642893 hasConcept C2779282312 @default.
• W4306642893 hasConcept C2780401358 @default.
• W4306642893 hasConcept C71924100 @default.
• W4306642893 hasConceptScore W4306642893C126322002 @default.
• W4306642893 hasConceptScore W4306642893C142724271 @default.
• W4306642893 hasConceptScore W4306642893C159047783 @default.
• W4306642893 hasConceptScore W4306642893C203014093 @default.
• W4306642893 hasConceptScore W4306642893C2522874641 @default.
• W4306642893 hasConceptScore W4306642893C2776914184 @default.
• W4306642893 hasConceptScore W4306642893C2777546802 @default.
• W4306642893 hasConceptScore W4306642893C2779282312 @default.
• W4306642893 hasConceptScore W4306642893C2780401358 @default.
• W4306642893 hasConceptScore W4306642893C71924100 @default.
• W4306642893 hasFunder F4320310758 @default.
• W4306642893 hasIssue "43" @default.
• W4306642893 hasLocation W43066428931 @default.
• W4306642893 hasLocation W43066428932 @default.
• W4306642893 hasLocation W43066428933 @default.
• W4306642893 hasOpenAccess W4306642893 @default.
• W4306642893 hasPrimaryLocation W43066428931 @default.
• W4306642893 hasRelatedWork W2016052042 @default.
• W4306642893 hasRelatedWork W2107100610 @default.
• W4306642893 hasRelatedWork W2121676840 @default.
• W4306642893 hasRelatedWork W2137571122 @default.
• W4306642893 hasRelatedWork W2147629250 @default.

• next