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• W4306649918 startingPage "3941" @default.
• W4306649918 abstract "A selective intermolecular amino-trifluoromethylation of alkenes is developed to produce a range of biologically active β-trifluoromethyl amines. This method exploits a crucial high-valent Cu(III)−CF3 complex as a combined source of CF3 radical and Cu(II) oxidant through homolytic Cu(III)−CF3 bond cleavage. This unique mode of CF3 radical generation is distinct from current dominant methods that rely largely on photoredox catalysis or the use of sacrificing radical initiator. This represents a significant advantage in that it greatly simplifies the reaction conditions, brings about operational convenience, and is beneficial to suppress various side reactions under otherwise more complicated conditions. A tertiary alkyl radical generated from addition of CF3 radical to alkenes is proposed to react with amines to enable C−N formation with the assistance of in-situ Cu(II) oxidant. This reaction shows good chemo- and regio-selectivity, suppressing a number of potential side reactions. The free manipulation of readily available Cu(III)−CF3 compound and feedstock compounds of alkenes and anilines greatly broadens the reaction scope. The good chemo- and regioselectivity, and operational convenience make this reaction attractive from the synthetic viewpoint. The reactivity of high-valent Cu(III)−CF3 compounds disclosed in this study may be exploited to develop other interesting reactions, and to enrich the currently underdeveloped Cu(III) chemistry." @default.
• W4306649918 created "2022-10-18" @default.
• W4306649918 creator A5044314141 @default.
• W4306649918 creator A5080298585 @default.
• W4306649918 date "2022-11-07" @default.
• W4306649918 modified "2023-09-29" @default.
• W4306649918 title "Selective Intermolecular Dual Amino‐Trifluoromethylation of Alkenes by High‐Valent Cu(III)−CF ₃ Compounds" @default.
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