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- W4306660738 endingPage "e202201526" @default.
- W4306660738 startingPage "e202201526" @default.
- W4306660738 abstract "Mitochondria play a key role in cellular energy metabolism. Transitions between glycolytic and respiratory conditions induce considerable adaptations of the cellular proteome. These metabolism-dependent changes are particularly pronounced for the protein composition of mitochondria. Here, we show that the yeast cytosolic ubiquitin conjugase Ubc8 plays a crucial role in the remodeling process when cells transition from respiratory to fermentative conditions. Ubc8 is a conserved and well-studied component of the catabolite control system that is known to regulate the stability of gluconeogenic enzymes. Unexpectedly, we found that Ubc8 also promotes the assembly of the translocase of the outer membrane of mitochondria (TOM) and increases the levels of its cytosol-exposed receptor subunit Tom22. Ubc8 deficiency results in compromised protein import into mitochondria and reduced steady-state levels of mitochondrial proteins. Our observations show that Ubc8, which is controlled by the prevailing metabolic conditions, promotes the switch from glucose synthesis to glucose usage in the cytosol and induces the biogenesis of the mitochondrial TOM machinery to improve mitochondrial protein import during phases of metabolic transition." @default.
- W4306660738 created "2022-10-18" @default.
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- W4306660738 date "2022-10-17" @default.
- W4306660738 modified "2023-10-14" @default.
- W4306660738 title "The metabolite-controlled ubiquitin conjugase Ubc8 promotes mitochondrial protein import" @default.
- W4306660738 cites W120247693 @default.
- W4306660738 cites W1486030469 @default.
- W4306660738 cites W1790363592 @default.
- W4306660738 cites W1966813886 @default.
- W4306660738 cites W1966918880 @default.
- W4306660738 cites W1968403457 @default.
- W4306660738 cites W1970587132 @default.
- W4306660738 cites W1972399884 @default.
- W4306660738 cites W1972576217 @default.
- W4306660738 cites W1980445163 @default.
- W4306660738 cites W1984442538 @default.
- W4306660738 cites W2000702106 @default.
- W4306660738 cites W2002364392 @default.
- W4306660738 cites W2004427906 @default.
- W4306660738 cites W2004912302 @default.
- W4306660738 cites W2005166958 @default.
- W4306660738 cites W2006587882 @default.
- W4306660738 cites W2012861249 @default.
- W4306660738 cites W2019050932 @default.
- W4306660738 cites W2031722533 @default.
- W4306660738 cites W2033062319 @default.
- W4306660738 cites W2036321220 @default.
- W4306660738 cites W2036727331 @default.
- W4306660738 cites W2036799174 @default.
- W4306660738 cites W2042688172 @default.
- W4306660738 cites W2046714225 @default.
- W4306660738 cites W2047862727 @default.
- W4306660738 cites W2056026047 @default.
- W4306660738 cites W2057015366 @default.
- W4306660738 cites W2068068551 @default.
- W4306660738 cites W2071719438 @default.
- W4306660738 cites W2076972400 @default.
- W4306660738 cites W2080752012 @default.
- W4306660738 cites W2084520521 @default.
- W4306660738 cites W2086660631 @default.
- W4306660738 cites W2088170262 @default.
- W4306660738 cites W2102878034 @default.
- W4306660738 cites W2105754268 @default.
- W4306660738 cites W2107277218 @default.
- W4306660738 cites W2110065044 @default.
- W4306660738 cites W2122598723 @default.
- W4306660738 cites W2127107002 @default.
- W4306660738 cites W2133376865 @default.
- W4306660738 cites W2135588013 @default.
- W4306660738 cites W2137158408 @default.
- W4306660738 cites W2140946052 @default.
- W4306660738 cites W2142437744 @default.
- W4306660738 cites W2146512944 @default.
- W4306660738 cites W2148356887 @default.
- W4306660738 cites W2152012295 @default.
- W4306660738 cites W2154046032 @default.
- W4306660738 cites W2165011536 @default.
- W4306660738 cites W2169333620 @default.
- W4306660738 cites W2192080449 @default.
- W4306660738 cites W2192505968 @default.
- W4306660738 cites W2415868510 @default.
- W4306660738 cites W2514536052 @default.
- W4306660738 cites W2529905170 @default.
- W4306660738 cites W2544360569 @default.
- W4306660738 cites W2582862246 @default.
- W4306660738 cites W2594933406 @default.
- W4306660738 cites W2697643565 @default.
- W4306660738 cites W2742457004 @default.
- W4306660738 cites W2770295596 @default.
- W4306660738 cites W2770699742 @default.
- W4306660738 cites W2795376620 @default.
- W4306660738 cites W2806543441 @default.
- W4306660738 cites W2808848024 @default.
- W4306660738 cites W2891994229 @default.
- W4306660738 cites W2899760200 @default.
- W4306660738 cites W2914081190 @default.
- W4306660738 cites W2921442251 @default.
- W4306660738 cites W2945313386 @default.
- W4306660738 cites W2946361803 @default.
- W4306660738 cites W2963569350 @default.
- W4306660738 cites W2979472203 @default.
- W4306660738 cites W2981762839 @default.
- W4306660738 cites W2989453214 @default.
- W4306660738 cites W3002262305 @default.
- W4306660738 cites W3010882806 @default.
- W4306660738 cites W3011606873 @default.