FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306673424> ?p ?o ?g. }

• W4306673424 abstract "Background Non-alcoholic fatty liver disease (NAFLD), a metabolic disorder that develops from non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH), has become an epidemic of chronic liver dysfunction worldwide. However, mechanisms that govern the transition from NAFL to NASH have not been fully elucidated. Methods Gene expression profile data of NAFLD liver tissues were obtained from Gene Expression Omnibus (GEO), including three microarray datasets with 60 NAFL and 44 NASH patients. Integrative differentially expressed genes (DEGs) between NAFL and NASH patients were identified using robust rank aggregation (RRA) analysis. Hub genes were identified combined with gene ontology functional annotation and protein–protein interaction network construction and validated using a sequencing dataset. Huh-7 cells with palmitate-induced lipid overload and NAFLD-diet mouse model of different stages were used to verify our findings. Results RRA analysis determined 70 robust DEGs between NAFL and NASH. The most robustly upregulated genes were SPP1 , AKR1B10 , CHST9 , and ANXA2 , while the most robustly downregulated DEGs were SNORD94 , SCARNA10 , SNORA20 , and MT1M . Cellular response to zinc ion (GO: 0071294) ranked first in GO analysis of downregulated genes, and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment showed that mineral absorption (hsa04978) was significantly enriched. The involvement of the metallothionein pathway was further validated by the decrease of Mt1 expression during NAFL to NASH progression in NAFLD mice and the protection from lipotoxicity in liver cells by overexpressing MT1M. Conclusions Our integrated analysis identified novel gene signatures and provided comprehensive molecular mechanisms underlying the transition from NAFL to NASH. Metallothionein might be a potential intervention target for NAFLD progression." @default.
• W4306673424 created "2022-10-19" @default.
• W4306673424 creator A5010426520 @default.
• W4306673424 creator A5023689602 @default.
• W4306673424 creator A5025603106 @default.
• W4306673424 creator A5027835055 @default.
• W4306673424 creator A5028455460 @default.
• W4306673424 creator A5034579831 @default.
• W4306673424 creator A5037435568 @default.
• W4306673424 creator A5044367029 @default.
• W4306673424 creator A5071007138 @default.
• W4306673424 creator A5071282540 @default.
• W4306673424 creator A5078061801 @default.
• W4306673424 date "2022-10-18" @default.
• W4306673424 modified "2023-10-08" @default.
• W4306673424 title "Integration analysis identifies the role of metallothionein in the progression from hepatic steatosis to steatohepatitis" @default.
• W4306673424 cites W1598102702 @default.
• W4306673424 cites W1977036235 @default.
• W4306673424 cites W2003052058 @default.
• W4306673424 cites W2009909460 @default.
• W4306673424 cites W2022273281 @default.
• W4306673424 cites W2055082498 @default.
• W4306673424 cites W2076307783 @default.
• W4306673424 cites W2079904598 @default.
• W4306673424 cites W2090054300 @default.
• W4306673424 cites W2114986055 @default.
• W4306673424 cites W2144178804 @default.
• W4306673424 cites W2146511318 @default.
• W4306673424 cites W2154981570 @default.
• W4306673424 cites W2158217645 @default.
• W4306673424 cites W2159352938 @default.
• W4306673424 cites W2204688218 @default.
• W4306673424 cites W2288699132 @default.
• W4306673424 cites W2321179708 @default.
• W4306673424 cites W2349020488 @default.
• W4306673424 cites W2502991882 @default.
• W4306673424 cites W2726642211 @default.
• W4306673424 cites W2765883724 @default.
• W4306673424 cites W2767967189 @default.
• W4306673424 cites W2810423511 @default.
• W4306673424 cites W2913699817 @default.
• W4306673424 cites W2947945403 @default.
• W4306673424 cites W2969166296 @default.
• W4306673424 cites W2981306881 @default.
• W4306673424 cites W2989141882 @default.
• W4306673424 cites W2991127841 @default.
• W4306673424 cites W3011425408 @default.
• W4306673424 cites W3015815440 @default.
• W4306673424 cites W3047696176 @default.
• W4306673424 doi "https://doi.org/10.3389/fendo.2022.951093" @default.
• W4306673424 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36329886" @default.
• W4306673424 hasPublicationYear "2022" @default.
• W4306673424 type Work @default.
• W4306673424 citedByCount "0" @default.
• W4306673424 crossrefType "journal-article" @default.
• W4306673424 hasAuthorship W4306673424A5010426520 @default.
• W4306673424 hasAuthorship W4306673424A5023689602 @default.
• W4306673424 hasAuthorship W4306673424A5025603106 @default.
• W4306673424 hasAuthorship W4306673424A5027835055 @default.
• W4306673424 hasAuthorship W4306673424A5028455460 @default.
• W4306673424 hasAuthorship W4306673424A5034579831 @default.
• W4306673424 hasAuthorship W4306673424A5037435568 @default.
• W4306673424 hasAuthorship W4306673424A5044367029 @default.
• W4306673424 hasAuthorship W4306673424A5071007138 @default.
• W4306673424 hasAuthorship W4306673424A5071282540 @default.
• W4306673424 hasAuthorship W4306673424A5078061801 @default.
• W4306673424 hasBestOaLocation W43066734241 @default.
• W4306673424 hasConcept C104317684 @default.
• W4306673424 hasConcept C126322002 @default.
• W4306673424 hasConcept C134018914 @default.
• W4306673424 hasConcept C150194340 @default.
• W4306673424 hasConcept C152724338 @default.
• W4306673424 hasConcept C162317418 @default.
• W4306673424 hasConcept C2776175330 @default.
• W4306673424 hasConcept C2777391703 @default.
• W4306673424 hasConcept C2778772119 @default.
• W4306673424 hasConcept C2779134260 @default.
• W4306673424 hasConcept C2779478299 @default.
• W4306673424 hasConcept C44353895 @default.
• W4306673424 hasConcept C511355011 @default.
• W4306673424 hasConcept C54355233 @default.
• W4306673424 hasConcept C70721500 @default.
• W4306673424 hasConcept C71924100 @default.
• W4306673424 hasConcept C8415881 @default.
• W4306673424 hasConcept C86803240 @default.
• W4306673424 hasConceptScore W4306673424C104317684 @default.
• W4306673424 hasConceptScore W4306673424C126322002 @default.
• W4306673424 hasConceptScore W4306673424C134018914 @default.
• W4306673424 hasConceptScore W4306673424C150194340 @default.
• W4306673424 hasConceptScore W4306673424C152724338 @default.
• W4306673424 hasConceptScore W4306673424C162317418 @default.
• W4306673424 hasConceptScore W4306673424C2776175330 @default.
• W4306673424 hasConceptScore W4306673424C2777391703 @default.
• W4306673424 hasConceptScore W4306673424C2778772119 @default.
• W4306673424 hasConceptScore W4306673424C2779134260 @default.
• W4306673424 hasConceptScore W4306673424C2779478299 @default.
• W4306673424 hasConceptScore W4306673424C44353895 @default.
• W4306673424 hasConceptScore W4306673424C511355011 @default.
• W4306673424 hasConceptScore W4306673424C54355233 @default.
• W4306673424 hasConceptScore W4306673424C70721500 @default.

• next