Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306683000> ?p ?o ?g. }
- W4306683000 endingPage "109281" @default.
- W4306683000 startingPage "109281" @default.
- W4306683000 abstract "Photorefractive keratectomy (PRK) is an alternative to LASIK and can cause intense acute pain that is often not relieved by standard treatments. To assess potential therapeutics for this type of acute pain, appropriate preclinical models are needed. We describe a preclinical corneal abrasion rat model that simulates the initial stages of PRK surgery and demonstrates similar pain and tear dysfunction as seen clinically. We used both behavioral and homeostatic assays to determine the therapeutic potential of resveratrol on pain and tear production. Studies were conducted in male and female Sprague-Dawley rats. Heptanol was applied to one eye and the superficial corneal epithelium was removed, mimicking the abrasion used in PRK. Spontaneous pain was assessed with orbital tightening (OT) scores for 7 days. Topical resveratrol increased OT scores sex-specifically in abraded males, but not females, at 72 h and 1 week after abrasion. Resveratrol increased tear production in abraded males, with no effect in abraded females. There was no correlation between OT score at 1 week and tear production measurements, demonstrating no relationship between spontaneous ocular pain and tear dysfunction in this model. These findings demonstrate the usefulness of our corneal abrasion preclinical PRK model for the assessment of ocular pain therapeutics and indicate that topical resveratrol may not be useful for managing PRK-induced pain." @default.
- W4306683000 created "2022-10-19" @default.
- W4306683000 creator A5002928969 @default.
- W4306683000 creator A5009859329 @default.
- W4306683000 creator A5026867291 @default.
- W4306683000 creator A5053650946 @default.
- W4306683000 creator A5056024832 @default.
- W4306683000 creator A5063017665 @default.
- W4306683000 creator A5064899043 @default.
- W4306683000 creator A5075056690 @default.
- W4306683000 date "2022-12-01" @default.
- W4306683000 modified "2023-10-10" @default.
- W4306683000 title "Resveratrol increases tear production and ocular pain after corneal abrasion in male, but not female, rats using a photorefractive keratectomy model" @default.
- W4306683000 cites W1273806924 @default.
- W4306683000 cites W1488123975 @default.
- W4306683000 cites W1781581452 @default.
- W4306683000 cites W1929334858 @default.
- W4306683000 cites W1963898471 @default.
- W4306683000 cites W1967257204 @default.
- W4306683000 cites W1977924327 @default.
- W4306683000 cites W1979501382 @default.
- W4306683000 cites W1981323427 @default.
- W4306683000 cites W2004698731 @default.
- W4306683000 cites W2005198003 @default.
- W4306683000 cites W2018661336 @default.
- W4306683000 cites W2035154605 @default.
- W4306683000 cites W2036064915 @default.
- W4306683000 cites W2048729493 @default.
- W4306683000 cites W2057198873 @default.
- W4306683000 cites W2062890300 @default.
- W4306683000 cites W2063037683 @default.
- W4306683000 cites W2064849125 @default.
- W4306683000 cites W2065567466 @default.
- W4306683000 cites W2074600897 @default.
- W4306683000 cites W2084500631 @default.
- W4306683000 cites W2104689898 @default.
- W4306683000 cites W2127934652 @default.
- W4306683000 cites W2128228874 @default.
- W4306683000 cites W2150974892 @default.
- W4306683000 cites W2165756914 @default.
- W4306683000 cites W2235736669 @default.
- W4306683000 cites W2239354195 @default.
- W4306683000 cites W2341566283 @default.
- W4306683000 cites W2410079542 @default.
- W4306683000 cites W2416076068 @default.
- W4306683000 cites W2582640368 @default.
- W4306683000 cites W2588897146 @default.
- W4306683000 cites W2607356893 @default.
- W4306683000 cites W2735693687 @default.
- W4306683000 cites W2765864581 @default.
- W4306683000 cites W2770966699 @default.
- W4306683000 cites W2792012938 @default.
- W4306683000 cites W2797719508 @default.
- W4306683000 cites W2883749679 @default.
- W4306683000 cites W2885414854 @default.
- W4306683000 cites W2913737767 @default.
- W4306683000 cites W2920044645 @default.
- W4306683000 cites W2936561167 @default.
- W4306683000 cites W2940813786 @default.
- W4306683000 cites W2950301126 @default.
- W4306683000 cites W2980799755 @default.
- W4306683000 cites W2995021309 @default.
- W4306683000 cites W3008834816 @default.
- W4306683000 cites W3032101410 @default.
- W4306683000 cites W3036725125 @default.
- W4306683000 cites W3081914143 @default.
- W4306683000 cites W3087571887 @default.
- W4306683000 cites W3094249009 @default.
- W4306683000 cites W3121990332 @default.
- W4306683000 cites W3125562536 @default.
- W4306683000 cites W3154973448 @default.
- W4306683000 cites W3212052749 @default.
- W4306683000 cites W1979278485 @default.
- W4306683000 doi "https://doi.org/10.1016/j.exer.2022.109281" @default.
- W4306683000 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36265575" @default.
- W4306683000 hasPublicationYear "2022" @default.
- W4306683000 type Work @default.
- W4306683000 citedByCount "1" @default.
- W4306683000 crossrefType "journal-article" @default.
- W4306683000 hasAuthorship W4306683000A5002928969 @default.
- W4306683000 hasAuthorship W4306683000A5009859329 @default.
- W4306683000 hasAuthorship W4306683000A5026867291 @default.
- W4306683000 hasAuthorship W4306683000A5053650946 @default.
- W4306683000 hasAuthorship W4306683000A5056024832 @default.
- W4306683000 hasAuthorship W4306683000A5063017665 @default.
- W4306683000 hasAuthorship W4306683000A5064899043 @default.
- W4306683000 hasAuthorship W4306683000A5075056690 @default.
- W4306683000 hasConcept C118231568 @default.
- W4306683000 hasConcept C118487528 @default.
- W4306683000 hasConcept C127413603 @default.
- W4306683000 hasConcept C141071460 @default.
- W4306683000 hasConcept C2776621570 @default.
- W4306683000 hasConcept C2776882836 @default.
- W4306683000 hasConcept C2778275304 @default.
- W4306683000 hasConcept C2779257441 @default.
- W4306683000 hasConcept C2779513239 @default.
- W4306683000 hasConcept C2780603455 @default.
- W4306683000 hasConcept C42219234 @default.