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- W4306684311 abstract "Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines ALS using published data (3, 4). We found significant differential expression of CXCL5, encoding C-X-C motif chemokine ligand 5, in iPSC-derived motor neurons of patients with ALS. CXCL5 was also differentially expressed in fibroblasts isolated from patients with ALS. CXCL5 transcript was present at significantly higher levels in ALS patient iPSC-derived motor neurons. These analyses will begin to define the transcriptional landscape of ALS." @default.
- W4306684311 created "2022-10-19" @default.
- W4306684311 creator A5024900493 @default.
- W4306684311 date "2022-10-17" @default.
- W4306684311 modified "2023-09-27" @default.
- W4306684311 title "Differential expression of CXCL5 in amyotrophic lateral sclerosis." @default.
- W4306684311 doi "https://doi.org/10.31219/osf.io/r2tve" @default.
- W4306684311 hasPublicationYear "2022" @default.
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