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• W4306699097 abstract "Phytochemical study on the methanol extract of the stems and leaves of Kadsura induta led to the isolation of six dibenzocyclooctadiene lignans, including three new compounds named kadsindutalignans A-C (1-3), and three known ones, heteroclitalignan B (4), kadsuphilin C (5) and kadsulignan E (6). Their structures were elucidated based on extensive spectroscopic analyses, including HRESIMS, 1D- (1H NMR and 13C NMR), 2D-NMR (HSQC, HMBC, 1H-1H COSY and NOESY), and experimental circular dichroism (CD) spectra. All the isolates inhibited NO production in LPS-activated RAW264.7 cells with IC50 values in the range from 5.67 ± 0.54 µM to 38.19 ± 2.03 µM, compared to that of the positive control of NG-monomethyl-L-arginine acetate (L-NMMA) with an IC50 value of 8.90 ± 0.48 µM. Interestingly, the new compound 2 showed potential inhibition of NO production with an IC50 value of 5.67 ± 0.54 µM, which was higher than that of the positive control." @default.
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• W4306699097 date "2022-10-18" @default.
• W4306699097 modified "2023-10-18" @default.
• W4306699097 title "Kadsindutalignans A–C: three new dibenzocyclooctadiene lignans from <i>Kasura induta</i> A.C.Sm. and their nitric oxide production inhibitory activities" @default.
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• W4306699097 doi "https://doi.org/10.1080/14786419.2022.2134361" @default.
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