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- W4306702141 abstract "Cyanoacrylates define a class of inhibitors which are capable to form a transient covalent bond with a cysteine flanking the binding site, thereby increasing the residence time and prolonging the inhibitory effect on the target protein under nonequilibrium conditions. Herein, we describe the synthetic access to cyanoacrylate-based HDAC4 inhibitors and the procedures for the characterization of the transient nature of the covalent bond between cyanoacrylates and thiols or cysteines in HDAC4." @default.
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- W4306702141 date "2022-10-19" @default.
- W4306702141 modified "2023-09-26" @default.
- W4306702141 title "Synthesis and Characterization of Reversible Covalent HDAC4 Inhibitors" @default.
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- W4306702141 doi "https://doi.org/10.1007/978-1-0716-2788-4_14" @default.
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