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- W4306709688 endingPage "121109" @default.
- W4306709688 startingPage "121109" @default.
- W4306709688 abstract "The organic solute transporter α-β (OSTα-OSTβ) is a heteromeric transporter localized to the basolateral membranes of liver, intestinal, and kidney epithelial cells and functions to extrude bile acids and steroids from these tissues. OSTα-OSTβ expression is variable among species and tissues. This transporter plays important roles in maintaining BA homeostasis and may correlate with the progression of diseases relevant to cholestasis or BA malabsorption. Crosstalk between multiple nuclear receptors and cytokines reveals a more intricate means of regulating OSTα-OSTβ. Human OSTα/β and mouse Ostα/β promoters are endowed with binding sites for several transcription factors. This review aims to uncover the current regulatory mechanism of OSTα-OSTβ, explain the rationale underlying this approach and provide practical evidence. Therapeutic strategies targeting OSTα-OSTβ or its upstream regulators may be essential to correct abnormal BA levels and intervene in the progression of diseases relevant to the disturbance of BA homeostasis." @default.
- W4306709688 created "2022-10-19" @default.
- W4306709688 creator A5003579283 @default.
- W4306709688 creator A5024328555 @default.
- W4306709688 creator A5042467158 @default.
- W4306709688 date "2022-12-01" @default.
- W4306709688 modified "2023-10-18" @default.
- W4306709688 title "Advances in understanding the regulatory mechanism of organic solute transporter α-β" @default.
- W4306709688 cites W1530165617 @default.
- W4306709688 cites W1539913287 @default.
- W4306709688 cites W1559606798 @default.
- W4306709688 cites W1568604572 @default.
- W4306709688 cites W1675359132 @default.
- W4306709688 cites W1677336966 @default.
- W4306709688 cites W1757422535 @default.
- W4306709688 cites W1902431806 @default.
- W4306709688 cites W1966374931 @default.
- W4306709688 cites W1966514588 @default.
- W4306709688 cites W1974993651 @default.
- W4306709688 cites W1976621716 @default.
- W4306709688 cites W1976811057 @default.
- W4306709688 cites W1978400865 @default.
- W4306709688 cites W1979510879 @default.
- W4306709688 cites W1980440732 @default.
- W4306709688 cites W1982056201 @default.
- W4306709688 cites W1982715024 @default.
- W4306709688 cites W1982872296 @default.
- W4306709688 cites W1989068854 @default.
- W4306709688 cites W1989357395 @default.
- W4306709688 cites W2003716616 @default.
- W4306709688 cites W2004714632 @default.
- W4306709688 cites W2004788105 @default.
- W4306709688 cites W2005786213 @default.
- W4306709688 cites W2006807155 @default.
- W4306709688 cites W2018782206 @default.
- W4306709688 cites W2019349841 @default.
- W4306709688 cites W2021444563 @default.
- W4306709688 cites W2021998283 @default.
- W4306709688 cites W2026624791 @default.
- W4306709688 cites W2027921776 @default.
- W4306709688 cites W2032693719 @default.
- W4306709688 cites W2034040273 @default.
- W4306709688 cites W2039191963 @default.
- W4306709688 cites W2041451676 @default.
- W4306709688 cites W2044732314 @default.
- W4306709688 cites W2045519188 @default.
- W4306709688 cites W2045906674 @default.
- W4306709688 cites W2046658442 @default.
- W4306709688 cites W2046811888 @default.
- W4306709688 cites W2058677848 @default.
- W4306709688 cites W2067399088 @default.
- W4306709688 cites W2068061466 @default.
- W4306709688 cites W2068999507 @default.
- W4306709688 cites W2072440377 @default.
- W4306709688 cites W2073882423 @default.
- W4306709688 cites W2074176521 @default.
- W4306709688 cites W2076316749 @default.
- W4306709688 cites W2080774916 @default.
- W4306709688 cites W2088788142 @default.
- W4306709688 cites W2089117732 @default.
- W4306709688 cites W2089816578 @default.
- W4306709688 cites W2090786698 @default.
- W4306709688 cites W2091129636 @default.
- W4306709688 cites W2095053527 @default.
- W4306709688 cites W2095204419 @default.
- W4306709688 cites W2096828108 @default.
- W4306709688 cites W2097631494 @default.
- W4306709688 cites W2102434679 @default.
- W4306709688 cites W2107601240 @default.
- W4306709688 cites W2114288535 @default.
- W4306709688 cites W2117387366 @default.
- W4306709688 cites W2117901133 @default.
- W4306709688 cites W2119347606 @default.
- W4306709688 cites W2119406942 @default.
- W4306709688 cites W2121280124 @default.
- W4306709688 cites W2123898551 @default.
- W4306709688 cites W2125457175 @default.
- W4306709688 cites W2125524268 @default.
- W4306709688 cites W2127053222 @default.
- W4306709688 cites W2133197725 @default.
- W4306709688 cites W2135248587 @default.
- W4306709688 cites W2135551496 @default.
- W4306709688 cites W2137133685 @default.
- W4306709688 cites W2138139209 @default.
- W4306709688 cites W2140065347 @default.
- W4306709688 cites W2142541950 @default.
- W4306709688 cites W2146012023 @default.
- W4306709688 cites W2151552217 @default.
- W4306709688 cites W2157666185 @default.
- W4306709688 cites W2158593148 @default.
- W4306709688 cites W2160229439 @default.
- W4306709688 cites W2161215121 @default.
- W4306709688 cites W2166040974 @default.
- W4306709688 cites W2171990314 @default.
- W4306709688 cites W2173311307 @default.
- W4306709688 cites W2211700876 @default.
- W4306709688 cites W2254156951 @default.
- W4306709688 cites W2340964572 @default.