Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306725254> ?p ?o ?g. }
- W4306725254 endingPage "15" @default.
- W4306725254 startingPage "1" @default.
- W4306725254 abstract "The initiation and progression of allergic asthma (AA) are associated with complex interactions between inflammation and immune response. Herein, we report the specific mechanisms underlying the molecular action of interferon (IFN)-γ in AA regulation. We speculated that IFN-γ inhibits Th9 differentiation by regulating the secretion of interleukin (IL)-27 from dendritic cells (DCs), thereby suppressing airway inflammation in asthma. We constructed a mouse model of ovalbumin-induced AA and overexpressed IFN-γ to evaluate the effect on the IL-27/Th9 axis via the in vitro effect of IFN-γ on IL-27 secretion by DCs and their influence on Th9 differentiation and asthmatic inflammation. IFN-γ overexpression reduced the proportion of Th9 cells and DCs and altered lung morphology and cytokine production in AA-induced mice, thus suppressing the AA phenotype. In addition, exogenous IFN-γ stimulation promoted the secretion of IL-27 and suppressed Th9 differentiation of CD4+ T cells via signal transducer and activator of transcription 1/3 (STAT1/3) signaling in a time-dependent manner. This study aimed to clarify the regulatory effect and mechanism of the IFN-γ/DCs/IL-27/Th9 axis on AA and provide novel insights for effective targeted treatment of asthma." @default.
- W4306725254 created "2022-10-19" @default.
- W4306725254 creator A5000740143 @default.
- W4306725254 creator A5005755707 @default.
- W4306725254 creator A5016406182 @default.
- W4306725254 creator A5030536674 @default.
- W4306725254 creator A5031145569 @default.
- W4306725254 creator A5060877237 @default.
- W4306725254 creator A5089952788 @default.
- W4306725254 date "2022-10-18" @default.
- W4306725254 modified "2023-09-25" @default.
- W4306725254 title "Interferon-γ Stimulates Interleukin-27 Derived from Dendritic Cells to Regulate Th9 Differentiation through STAT1/3 Pathway" @default.
- W4306725254 cites W1070777618 @default.
- W4306725254 cites W1482193400 @default.
- W4306725254 cites W1488600638 @default.
- W4306725254 cites W1894502267 @default.
- W4306725254 cites W1919714885 @default.
- W4306725254 cites W1946410206 @default.
- W4306725254 cites W1963632824 @default.
- W4306725254 cites W1967261754 @default.
- W4306725254 cites W1978284058 @default.
- W4306725254 cites W1998118765 @default.
- W4306725254 cites W2012675566 @default.
- W4306725254 cites W2030345324 @default.
- W4306725254 cites W2034938909 @default.
- W4306725254 cites W2039989099 @default.
- W4306725254 cites W2040459409 @default.
- W4306725254 cites W2046776172 @default.
- W4306725254 cites W2052873213 @default.
- W4306725254 cites W2061882872 @default.
- W4306725254 cites W2066740231 @default.
- W4306725254 cites W2090021858 @default.
- W4306725254 cites W2099061596 @default.
- W4306725254 cites W2099892391 @default.
- W4306725254 cites W2117582728 @default.
- W4306725254 cites W2118736569 @default.
- W4306725254 cites W2121763901 @default.
- W4306725254 cites W2137368119 @default.
- W4306725254 cites W2150722068 @default.
- W4306725254 cites W2159497705 @default.
- W4306725254 cites W2162790692 @default.
- W4306725254 cites W2167130647 @default.
- W4306725254 cites W2167593148 @default.
- W4306725254 cites W2498440288 @default.
- W4306725254 cites W2509074682 @default.
- W4306725254 cites W2526232613 @default.
- W4306725254 cites W2605869276 @default.
- W4306725254 cites W2619764592 @default.
- W4306725254 cites W2726501529 @default.
- W4306725254 cites W2736635522 @default.
- W4306725254 cites W2744562444 @default.
- W4306725254 cites W2784110492 @default.
- W4306725254 cites W2808189115 @default.
- W4306725254 cites W2884816733 @default.
- W4306725254 cites W2888157059 @default.
- W4306725254 cites W2898864613 @default.
- W4306725254 cites W2900859169 @default.
- W4306725254 cites W2939247829 @default.
- W4306725254 cites W2945085089 @default.
- W4306725254 cites W2966381978 @default.
- W4306725254 cites W3023549492 @default.
- W4306725254 cites W3037760671 @default.
- W4306725254 cites W3090823323 @default.
- W4306725254 cites W4220947297 @default.
- W4306725254 cites W4282831246 @default.
- W4306725254 doi "https://doi.org/10.1155/2022/1542112" @default.
- W4306725254 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36304255" @default.
- W4306725254 hasPublicationYear "2022" @default.
- W4306725254 type Work @default.
- W4306725254 citedByCount "0" @default.
- W4306725254 crossrefType "journal-article" @default.
- W4306725254 hasAuthorship W4306725254A5000740143 @default.
- W4306725254 hasAuthorship W4306725254A5005755707 @default.
- W4306725254 hasAuthorship W4306725254A5016406182 @default.
- W4306725254 hasAuthorship W4306725254A5030536674 @default.
- W4306725254 hasAuthorship W4306725254A5031145569 @default.
- W4306725254 hasAuthorship W4306725254A5060877237 @default.
- W4306725254 hasAuthorship W4306725254A5089952788 @default.
- W4306725254 hasBestOaLocation W43067252541 @default.
- W4306725254 hasConcept C134018914 @default.
- W4306725254 hasConcept C145430368 @default.
- W4306725254 hasConcept C171958077 @default.
- W4306725254 hasConcept C191732599 @default.
- W4306725254 hasConcept C203014093 @default.
- W4306725254 hasConcept C2776178377 @default.
- W4306725254 hasConcept C2776914184 @default.
- W4306725254 hasConcept C2776946954 @default.
- W4306725254 hasConcept C2777003663 @default.
- W4306725254 hasConcept C2778277574 @default.
- W4306725254 hasConcept C2778690821 @default.
- W4306725254 hasConcept C2778923194 @default.
- W4306725254 hasConcept C2779675166 @default.
- W4306725254 hasConcept C2909016868 @default.
- W4306725254 hasConcept C49039625 @default.
- W4306725254 hasConcept C62478195 @default.
- W4306725254 hasConcept C74172505 @default.
- W4306725254 hasConcept C86803240 @default.
- W4306725254 hasConcept C8891405 @default.