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- W4306725878 abstract "Diethyldithiocarbamate zinc (Zn(DDC)2), has shown promising antineoplastic effects against a wide variety of cancers. However, this application was hindered by its poor water solubility. Therefore, complexation with cyclodextrin was used to enhance the solubility. Five different concentrations of 2-hydroxyl beta-cyclodextrin (HP) and ether beta-cyclodextrin (SBE) were used. CD-Zn(DDC)2 solutions were freez-dried for further characterisation using DSC, TGA and FT-IR. The phase solubility study showed a significant water-solubility enchantment of Zn(DDC)2, and the characterisation studies confirmed the formation of inclusion complexes CD-Zn(DDC)2. Overall, CDs have improved Zn(DDC)2 solubility significantly and showed a promising anticancer activity against lung cancer cells. Hence, CD-Zn(DDC)2 complexes have a great potential for further studies against cancer. " @default.
- W4306725878 created "2022-10-19" @default.
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- W4306725878 date "2022-11-02" @default.
- W4306725878 modified "2023-09-30" @default.
- W4306725878 title "Solubility Enhancement for Dietheyldithiocarbamate-Zinc for Lung Cancer Treatment" @default.
- W4306725878 doi "https://doi.org/10.5920/bjpharm.1147" @default.
- W4306725878 hasPublicationYear "2022" @default.
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