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- W4306729853 abstract "Class I histone deacetylases (HDACs) are important regulators of cellular functions in health and disease. HDAC1, HDAC2, HDAC3, and HDAC8 are promising targets for the treatment of cancer, neurological, and immunological disorders. These enzymes have both catalytic and non-catalytic functions in the regulation of gene expression. We here describe the generation of a genetic toolbox by the CRISPR/Cas9 methodology in nearly haploid human tumor cells. This novel model system allows to discriminate between catalytic and structural functions of class I HDAC enzymes and to mimic the treatment with specific HDAC inhibitors." @default.
- W4306729853 created "2022-10-19" @default.
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- W4306729853 date "2022-10-19" @default.
- W4306729853 modified "2023-09-26" @default.
- W4306729853 title "Development of a Cellular Model Mimicking Specific HDAC Inhibitors" @default.
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- W4306729853 doi "https://doi.org/10.1007/978-1-0716-2788-4_4" @default.
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