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- W4306737496 endingPage "65" @default.
- W4306737496 startingPage "65" @default.
- W4306737496 abstract "The constant region of the immunoglobulin (IG) or antibody heavy gamma chain is frequently engineered to modify the effector properties of the therapeutic monoclonal antibodies. These variants are classified in regards to their effects on effector functions, antibody-dependent cytotoxicity (ADCC), antibody-dependent phagocytosis (ADCP), complement-dependent cytotoxicity (CDC) enhancement or reduction, B cell inhibition by the coengagement of antigen and FcγR on the same cell, on half-life increase, and/or on structure such as prevention of IgG4 half-IG exchange, hexamerisation, knobs-into-holes and the heteropairing H-H of bispecific antibodies, absence of disulfide bridge inter H-L, absence of glycosylation site, and site-specific drug attachment engineered cysteine. The IMGT engineered variant identifier is comprised of the species and gene name (and eventually allele), the letter 'v' followed by a number (assigned chronologically), and for each concerned domain (e.g, CH1, h, CH2 and CH3), the novel AA (single letter abbreviation) and IMGT position according to the IMGT unique numbering for the C-domain and between parentheses, the Eu numbering. IMGT engineered variants are described with detailed amino acid changes, visualized in motifs based on the IMGT numbering bridging genes, sequences, and structures for higher order description." @default.
- W4306737496 created "2022-10-19" @default.
- W4306737496 creator A5070104167 @default.
- W4306737496 creator A5074625213 @default.
- W4306737496 date "2022-10-18" @default.
- W4306737496 modified "2023-09-26" @default.
- W4306737496 title "IMGT® Nomenclature of Engineered IGHG Variants Involved in Antibody Effector Properties and Formats" @default.
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