Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306746262> ?p ?o ?g. }
- W4306746262 endingPage "146" @default.
- W4306746262 startingPage "135" @default.
- W4306746262 abstract "BACKGROUND: An altered plasma fatty acid (FA) profile and desaturase activities have been associated with several metabolic diseases, including the MetS, but studies in the general populations are lacking, and only few studies have investigated a broad spectrum of FA in plasma phospholipids (PL). OBJECTIVE: We investigated, cross-sectionally, the relationship of the FA profile and desaturase activities in plasma PL with the prevalence of MetS in a general population in The Netherlands. METHODS: Baseline characteristic data from 850 participants (male: 50.2%) aged 38-68 years recruited in the Lifelines cohort study were obtained. The FA profile was determined in fasting plasma PL, and desaturase activities were estimated from product/precursor ratios. The MetS was defined according to International Diabetes Federation. Logistic regressions were used to examine the relation of the FA profile with the prevalence of MetS, and Bonferroni correction was applied to account for multiple testing. RESULTS: 151 participants (17.7%) had the MetS. After adjustment for several confounders and Bonferroni correction, higher tertiles of C18 : 0 (the early precursor of de novo lipogenesis pathway), C18 : 3n6 and C20 : 3n6 (both consistent with a high Δ6 desaturase (D6D) activity), and D6D activity itself were associated with a higher prevalence of MetS, while higher tertiles of C18 : 1n7, C24 : 0, and C24 : 1n9 (very long chain FA) as well as stearoyl-CoA desaturase (SCD)-18 were inversely associated with the MetS. CONCLUSIONS: This study shows that a wide-ranging plasma PL FA profile and estimated desaturase activities were different between adults with and without the MetS in a general representative population and implicates the importance of monitoring individual FAs and desaturase activities as novel modifiable biomarkers for the MetS." @default.
- W4306746262 created "2022-10-19" @default.
- W4306746262 creator A5010367070 @default.
- W4306746262 creator A5013020501 @default.
- W4306746262 creator A5017232068 @default.
- W4306746262 creator A5030097178 @default.
- W4306746262 creator A5038949732 @default.
- W4306746262 creator A5041146624 @default.
- W4306746262 creator A5080122516 @default.
- W4306746262 creator A5091158089 @default.
- W4306746262 date "2022-12-29" @default.
- W4306746262 modified "2023-10-16" @default.
- W4306746262 title "Plasma phospholipid fatty acid profile, estimated desaturase activities and prevalence of the metabolic syndrome in a general population cohort: A cross-sectional study" @default.
- W4306746262 cites W1895288631 @default.
- W4306746262 cites W1965062785 @default.
- W4306746262 cites W1978463257 @default.
- W4306746262 cites W2003347868 @default.
- W4306746262 cites W2003784331 @default.
- W4306746262 cites W2011869666 @default.
- W4306746262 cites W2017852953 @default.
- W4306746262 cites W2054571412 @default.
- W4306746262 cites W2095924588 @default.
- W4306746262 cites W2103516623 @default.
- W4306746262 cites W2110656045 @default.
- W4306746262 cites W2130073922 @default.
- W4306746262 cites W2134027848 @default.
- W4306746262 cites W2142323439 @default.
- W4306746262 cites W2143104968 @default.
- W4306746262 cites W2145820796 @default.
- W4306746262 cites W2151604950 @default.
- W4306746262 cites W2159959793 @default.
- W4306746262 cites W2163181319 @default.
- W4306746262 cites W2168526937 @default.
- W4306746262 cites W2318712031 @default.
- W4306746262 cites W2335278508 @default.
- W4306746262 cites W2761254197 @default.
- W4306746262 cites W2790295137 @default.
- W4306746262 cites W2793435470 @default.
- W4306746262 cites W2956101246 @default.
- W4306746262 cites W2972245663 @default.
- W4306746262 cites W2986141565 @default.
- W4306746262 cites W3027239459 @default.
- W4306746262 cites W3034949755 @default.
- W4306746262 cites W3045638927 @default.
- W4306746262 cites W3081196063 @default.
- W4306746262 cites W3083120354 @default.
- W4306746262 cites W3087133021 @default.
- W4306746262 cites W3172077583 @default.
- W4306746262 cites W4232558368 @default.
- W4306746262 cites W4243827040 @default.
- W4306746262 doi "https://doi.org/10.3233/nha-220155" @default.
- W4306746262 hasPublicationYear "2022" @default.
- W4306746262 type Work @default.
- W4306746262 citedByCount "0" @default.
- W4306746262 crossrefType "journal-article" @default.
- W4306746262 hasAuthorship W4306746262A5010367070 @default.
- W4306746262 hasAuthorship W4306746262A5013020501 @default.
- W4306746262 hasAuthorship W4306746262A5017232068 @default.
- W4306746262 hasAuthorship W4306746262A5030097178 @default.
- W4306746262 hasAuthorship W4306746262A5038949732 @default.
- W4306746262 hasAuthorship W4306746262A5041146624 @default.
- W4306746262 hasAuthorship W4306746262A5080122516 @default.
- W4306746262 hasAuthorship W4306746262A5091158089 @default.
- W4306746262 hasBestOaLocation W43067462621 @default.
- W4306746262 hasConcept C105795698 @default.
- W4306746262 hasConcept C126322002 @default.
- W4306746262 hasConcept C127808970 @default.
- W4306746262 hasConcept C134018914 @default.
- W4306746262 hasConcept C141359234 @default.
- W4306746262 hasConcept C151956035 @default.
- W4306746262 hasConcept C185592680 @default.
- W4306746262 hasConcept C201903717 @default.
- W4306746262 hasConcept C2780578515 @default.
- W4306746262 hasConcept C2908647359 @default.
- W4306746262 hasConcept C33923547 @default.
- W4306746262 hasConcept C4733338 @default.
- W4306746262 hasConcept C543025807 @default.
- W4306746262 hasConcept C55493867 @default.
- W4306746262 hasConcept C555293320 @default.
- W4306746262 hasConcept C71924100 @default.
- W4306746262 hasConcept C72563966 @default.
- W4306746262 hasConcept C77350462 @default.
- W4306746262 hasConcept C99454951 @default.
- W4306746262 hasConceptScore W4306746262C105795698 @default.
- W4306746262 hasConceptScore W4306746262C126322002 @default.
- W4306746262 hasConceptScore W4306746262C127808970 @default.
- W4306746262 hasConceptScore W4306746262C134018914 @default.
- W4306746262 hasConceptScore W4306746262C141359234 @default.
- W4306746262 hasConceptScore W4306746262C151956035 @default.
- W4306746262 hasConceptScore W4306746262C185592680 @default.
- W4306746262 hasConceptScore W4306746262C201903717 @default.
- W4306746262 hasConceptScore W4306746262C2780578515 @default.
- W4306746262 hasConceptScore W4306746262C2908647359 @default.
- W4306746262 hasConceptScore W4306746262C33923547 @default.
- W4306746262 hasConceptScore W4306746262C4733338 @default.
- W4306746262 hasConceptScore W4306746262C543025807 @default.
- W4306746262 hasConceptScore W4306746262C55493867 @default.
- W4306746262 hasConceptScore W4306746262C555293320 @default.