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• W4306751714 endingPage "2243" @default.
• W4306751714 startingPage "2221" @default.
• W4306751714 abstract "Personalized approaches in dermatology are designed to match the specific requirements based on the individual genetic makeup. One major factor accounting for the differences in skin phenotypes is single nucleotide polymorphism (SNP) within several genes with diverse roles that extend beyond skin tone and pigmentation. Therefore, the cellular sensitivities to the environmental stress and damage linked to extrinsic aging could also underlie the individual characteristics of the skin and dictate the unique skin care requirements. This study aimed to identify the likely biomarkers and molecular signatures expressed in skin cells of different ethnic backgrounds, which could aid further the design of personalized skin products based on specific demands.Using data mining and in-silico modeling, the association of SNP-affected genes with three major skin types of European, Asian and African origin was analyzed and compared within the structure-function gene interaction networks. Cultured dermal fibroblasts were subsequently subjected to ultraviolet radiation and oxidative stress and analyzed for DNA damage and senescent markers. The protective applications of two cosmetic ingredients, Resveratrol and Quercetin, were validated in both cellular and in-silico models.Each skin type was characterized by the presence of SNPs in the genes controlling facultative and constitutive pigmentation, which could also underlie the major differences in responses to photodamage, such as oxidative stress, inflammation, and barrier homeostasis. Skin-type-specific dermal fibroblasts cultured in-vitro demonstrated distinctive sensitivities to ultraviolet radiation and oxidative stress, which could be modulated further by the bioactive compounds with the predicted capacities to interact with some of the genes in the in-silico models.Evaluation of the SNP-affected gene networks and likely sensitivities of skin cells, defined as low threshold levels to extrinsic stress factors, can provide a valuable tool for the design and formulation of personalized skin products that match more accurately diverse ethnic backgrounds." @default.
• W4306751714 created "2022-10-19" @default.
• W4306751714 creator A5048042883 @default.
• W4306751714 creator A5090406521 @default.
• W4306751714 date "2022-10-01" @default.
• W4306751714 modified "2023-09-25" @default.
• W4306751714 title "Evaluation of Personalized Skincare Through in-silico Gene Interactive Networks and Cellular Responses to UVR and Oxidative Stress" @default.
• W4306751714 cites W1487081220 @default.
• W4306751714 cites W1528291192 @default.
• W4306751714 cites W1623863380 @default.
• W4306751714 cites W1944436417 @default.
• W4306751714 cites W1973081269 @default.
• W4306751714 cites W1973938553 @default.
• W4306751714 cites W1977254324 @default.
• W4306751714 cites W1978678832 @default.
• W4306751714 cites W1979085268 @default.
• W4306751714 cites W1979423929 @default.
• W4306751714 cites W1980051172 @default.
• W4306751714 cites W1980523931 @default.
• W4306751714 cites W1982311025 @default.
• W4306751714 cites W1982704806 @default.
• W4306751714 cites W1983125814 @default.
• W4306751714 cites W1985129442 @default.
• W4306751714 cites W1985389453 @default.
• W4306751714 cites W1985691243 @default.
• W4306751714 cites W1989970381 @default.
• W4306751714 cites W1991092008 @default.
• W4306751714 cites W1992993799 @default.
• W4306751714 cites W1994127346 @default.
• W4306751714 cites W1995087258 @default.
• W4306751714 cites W1996113298 @default.
• W4306751714 cites W1996142284 @default.
• W4306751714 cites W1997420388 @default.
• W4306751714 cites W1999879135 @default.
• W4306751714 cites W2003258166 @default.
• W4306751714 cites W2008087433 @default.
• W4306751714 cites W2010897349 @default.
• W4306751714 cites W2011693952 @default.
• W4306751714 cites W2015796460 @default.
• W4306751714 cites W2017136882 @default.
• W4306751714 cites W2025725196 @default.
• W4306751714 cites W2026209513 @default.
• W4306751714 cites W2027161175 @default.
• W4306751714 cites W2027827700 @default.
• W4306751714 cites W2027980060 @default.
• W4306751714 cites W2028199089 @default.
• W4306751714 cites W2034575591 @default.
• W4306751714 cites W2039773944 @default.
• W4306751714 cites W2046656687 @default.
• W4306751714 cites W2053724807 @default.
• W4306751714 cites W2055999471 @default.
• W4306751714 cites W2057882064 @default.
• W4306751714 cites W2062480234 @default.
• W4306751714 cites W2062665729 @default.
• W4306751714 cites W2063998511 @default.
• W4306751714 cites W2068944232 @default.
• W4306751714 cites W2070332388 @default.
• W4306751714 cites W2070638289 @default.
• W4306751714 cites W2080521432 @default.
• W4306751714 cites W2081850567 @default.
• W4306751714 cites W2091073356 @default.
• W4306751714 cites W2092039091 @default.
• W4306751714 cites W2099469300 @default.
• W4306751714 cites W2104665690 @default.
• W4306751714 cites W2106052620 @default.
• W4306751714 cites W2107304989 @default.
• W4306751714 cites W2109062539 @default.
• W4306751714 cites W2109627824 @default.
• W4306751714 cites W2120183307 @default.
• W4306751714 cites W2123602250 @default.
• W4306751714 cites W2124543958 @default.
• W4306751714 cites W2124735240 @default.
• W4306751714 cites W2127702552 @default.
• W4306751714 cites W2128725994 @default.
• W4306751714 cites W2129233990 @default.
• W4306751714 cites W2131602910 @default.
• W4306751714 cites W2141275577 @default.
• W4306751714 cites W2143088015 @default.
• W4306751714 cites W2146760247 @default.
• W4306751714 cites W2148558691 @default.
• W4306751714 cites W2152304671 @default.
• W4306751714 cites W2160576359 @default.
• W4306751714 cites W2161854858 @default.
• W4306751714 cites W2163556451 @default.
• W4306751714 cites W2168358106 @default.
• W4306751714 cites W2265820610 @default.
• W4306751714 cites W2294045289 @default.
• W4306751714 cites W2295976626 @default.
• W4306751714 cites W2409710963 @default.
• W4306751714 cites W2420758800 @default.
• W4306751714 cites W2435708719 @default.
• W4306751714 cites W2519643340 @default.
• W4306751714 cites W2520394603 @default.
• W4306751714 cites W2544642403 @default.
• W4306751714 cites W2552775806 @default.
• W4306751714 cites W2562513815 @default.
• W4306751714 cites W2564412416 @default.
• W4306751714 cites W2615834260 @default.

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