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- W4306752002 abstract "Considering the importance of miR-143 and miR-222 in carcinogenicity and the importance of miRSNPs in acute myeloid leukemia, this research was done to investigate the association of miR-143 rs4705342 and miR-222 rs2858060 polymorphisms with AML. In this investigation, 150 AML patients and 150 healthy subjects participated. Genotyping of selected polymorphisms was detected by T-ARMS-PCR technique, and data was analyzed using the SPSS (version 24) software. Our findings showed that the miR-143 rs4705342 TC genotype and C allele increase the susceptibility to AML ( P < 0.001). Moreover, the miR-222 rs2858060 CC genotype ( P = 0.019) increases the risk of AML, and the C allele in this polymorphism showed an increased risk for AML in the dominant mode ( P = 0.022). Haplotypes CC (OR:8.78, P < 0.001), CT (OR:0.42, P < 0.001) and GT (OR:0.61, P = 0.003) showed significant association with AML. We reported for the first time, miR-143 rs4705342 and miR-222 rs2858060 polymorphisms are associated with increased AML risk in Iranian subjects. • Micro RNAs affect a wide range of leukemic processes. • AML is the most common acute leukemia. • miR-143 and miR-222 play significant roles in the pathogenesis of leukemia. • Specific polymorphisms in these microRNA genes could predispose to the AML." @default.
- W4306752002 created "2022-10-19" @default.
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- W4306752002 date "2022-12-01" @default.
- W4306752002 modified "2023-09-25" @default.
- W4306752002 title "Evaluation of miR-143 rs4705342 and miR-222 rs2858060 genetic variants in patients with acute myeloid leukemia" @default.
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- W4306752002 doi "https://doi.org/10.1016/j.humgen.2022.201122" @default.
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