Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306752006> ?p ?o ?g. }
- W4306752006 endingPage "22.2022" @default.
- W4306752006 startingPage "ENEURO.0193" @default.
- W4306752006 abstract "The subthalamic nucleus (STN) is a small, excitatory nucleus that regulates the output of basal ganglia motor circuits. The functions of the STN and its role in the pathophysiology of Parkinson's disease are now well established. However, some basic characteristics like the developmental origin and molecular phenotype of neuronal subpopulations are still being debated. The classical model of forebrain development attributed the origin of STN within the diencephalon. Recent studies of gene expression patterns exposed shortcomings of the classical model. To accommodate these findings, the prosomeric model was developed. In this concept, STN develops within the hypothalamic primordium, which is no longer a part of the diencephalic primordium. This concept is further supported by the expression patterns of many transcription factors. It is interesting to note that many transcription factors involved in the development of the STN are also involved in the pathogenesis of neurodevelopmental disorders. Thus, the study of neurodevelopmental disorders could provide us with valuable information on the roles of these transcription factors in the development and maintenance of STN phenotype. In this review, we summarize historical theories about the developmental origin of the STN and interpret the gene expression data within the prosomeric conceptual framework. Finally, we discuss the importance of neurodevelopmental disorders for the development of the STN and its potential role in the pathophysiology of neurodevelopmental disorders." @default.
- W4306752006 created "2022-10-19" @default.
- W4306752006 creator A5063293322 @default.
- W4306752006 creator A5087715820 @default.
- W4306752006 creator A5089805347 @default.
- W4306752006 date "2022-09-01" @default.
- W4306752006 modified "2023-09-26" @default.
- W4306752006 title "Transcriptional Profile of the Developing Subthalamic Nucleus" @default.
- W4306752006 cites W1486532685 @default.
- W4306752006 cites W1513126258 @default.
- W4306752006 cites W1533604136 @default.
- W4306752006 cites W1535627121 @default.
- W4306752006 cites W1559125938 @default.
- W4306752006 cites W1571154609 @default.
- W4306752006 cites W1609321187 @default.
- W4306752006 cites W1625073821 @default.
- W4306752006 cites W1720193968 @default.
- W4306752006 cites W1858273353 @default.
- W4306752006 cites W1902497723 @default.
- W4306752006 cites W1922409394 @default.
- W4306752006 cites W1939276938 @default.
- W4306752006 cites W1963822938 @default.
- W4306752006 cites W1965330058 @default.
- W4306752006 cites W1966428626 @default.
- W4306752006 cites W1967733543 @default.
- W4306752006 cites W1968946540 @default.
- W4306752006 cites W1970783808 @default.
- W4306752006 cites W1972182320 @default.
- W4306752006 cites W1972856100 @default.
- W4306752006 cites W1974343890 @default.
- W4306752006 cites W1975897354 @default.
- W4306752006 cites W1976194722 @default.
- W4306752006 cites W1976306783 @default.
- W4306752006 cites W1976862716 @default.
- W4306752006 cites W1978664503 @default.
- W4306752006 cites W1979420712 @default.
- W4306752006 cites W1981098064 @default.
- W4306752006 cites W1982014300 @default.
- W4306752006 cites W1982157210 @default.
- W4306752006 cites W1983317608 @default.
- W4306752006 cites W1983350277 @default.
- W4306752006 cites W1985187126 @default.
- W4306752006 cites W1987844453 @default.
- W4306752006 cites W1990251289 @default.
- W4306752006 cites W1990448590 @default.
- W4306752006 cites W1993888492 @default.
- W4306752006 cites W1994338282 @default.
- W4306752006 cites W1996236954 @default.
- W4306752006 cites W1996973708 @default.
- W4306752006 cites W1997980747 @default.
- W4306752006 cites W1999672424 @default.
- W4306752006 cites W1999912808 @default.
- W4306752006 cites W2000646745 @default.
- W4306752006 cites W2001923242 @default.
- W4306752006 cites W2002464695 @default.
- W4306752006 cites W2002764043 @default.
- W4306752006 cites W2003672806 @default.
- W4306752006 cites W2008095538 @default.
- W4306752006 cites W2008327380 @default.
- W4306752006 cites W2008686569 @default.
- W4306752006 cites W2011678874 @default.
- W4306752006 cites W2012600481 @default.
- W4306752006 cites W2012666276 @default.
- W4306752006 cites W2012725470 @default.
- W4306752006 cites W2013726744 @default.
- W4306752006 cites W2015956021 @default.
- W4306752006 cites W2017812012 @default.
- W4306752006 cites W2017931574 @default.
- W4306752006 cites W2017993176 @default.
- W4306752006 cites W2020374419 @default.
- W4306752006 cites W2021782736 @default.
- W4306752006 cites W2024442264 @default.
- W4306752006 cites W2024602609 @default.
- W4306752006 cites W2025189468 @default.
- W4306752006 cites W2025698913 @default.
- W4306752006 cites W2026078852 @default.
- W4306752006 cites W2026682189 @default.
- W4306752006 cites W2026888593 @default.
- W4306752006 cites W2027234236 @default.
- W4306752006 cites W2027969818 @default.
- W4306752006 cites W2029881982 @default.
- W4306752006 cites W2030897912 @default.
- W4306752006 cites W2032363591 @default.
- W4306752006 cites W2035330121 @default.
- W4306752006 cites W2037936617 @default.
- W4306752006 cites W2038059446 @default.
- W4306752006 cites W2039493143 @default.
- W4306752006 cites W2040332486 @default.
- W4306752006 cites W2040683023 @default.
- W4306752006 cites W2040953801 @default.
- W4306752006 cites W2043418789 @default.
- W4306752006 cites W2045546866 @default.
- W4306752006 cites W2046254071 @default.
- W4306752006 cites W2046980494 @default.
- W4306752006 cites W2047471489 @default.
- W4306752006 cites W2047505539 @default.
- W4306752006 cites W2047847592 @default.
- W4306752006 cites W2047936342 @default.