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• W4306755639 abstract "Microbes frequently encounter heavy metals and other toxic compounds generated from natural biogeochemical processes and anthropogenic activities. Here, we analyzed the prevalence and association of genes conferring resistance to heavy metals, biocides, and antimicrobial compounds in 394 genome sequences of clinical human-derived S. enterica from New Hampshire, USA. The most prevalent was the gold operon (gesABC-golTSB), which was present in 99.2% of the genomes. In contrast, the other five heavy metal operons (arsenic, copper, mercury, silver, tellurite) were present in 0.76% (3/394)-5.58% (22/394) of the total population. The heavy metal operons and three biocide resistance genes were differentially distributed across 15 sequence types (STs) and 16 serotypes. The number of heavy metal operons and biocide resistance genes per genome was significantly associated with high number of antimicrobial resistance (AMR) genes per genome. Notable is the mercury operon which exhibited significant association with genes conferring resistance to aminoglycosides, cephalosporins, diaminopyrimidine, sulfonamide, and fosfomycin. The mercury operon was co-located with the AMR genes aac(3)-IV, ant(3)-IIa, aph(3')-Ia, and aph(4)-Ia, CTX-M-65, dfrA14, sul1, and fosA3 genes within the same plasmid types. Lastly, we found evidence for negative selection of individual genes of each heavy metal operon and the biocide resistance genes (dN/dS < 1). Our study highlights the need for continued surveillance of S. enterica serotypes that carry those genes that confer resistance to heavy metals and biocides that are often associated with mobile AMR genes. The selective pressures imposed by heavy metals and biocides on S. enterica may contribute to the co-selection and spread of AMR in human infections." @default.
• W4306755639 created "2022-10-19" @default.
• W4306755639 creator A5038947507 @default.
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• W4306755639 date "2022-10-19" @default.
• W4306755639 modified "2023-09-26" @default.
• W4306755639 title "Population analysis of heavy metal and biocide resistance genes in Salmonella enterica from human clinical cases in New Hampshire, United States" @default.
• W4306755639 cites W1489573774 @default.
• W4306755639 cites W1811709262 @default.
• W4306755639 cites W1972153129 @default.
• W4306755639 cites W1975534363 @default.
• W4306755639 cites W2024828640 @default.
• W4306755639 cites W2026012657 @default.
• W4306755639 cites W2039876034 @default.
• W4306755639 cites W2049550628 @default.
• W4306755639 cites W2058846600 @default.
• W4306755639 cites W2069289340 @default.
• W4306755639 cites W2082181044 @default.
• W4306755639 cites W2096093282 @default.
• W4306755639 cites W2102869413 @default.
• W4306755639 cites W2107772251 @default.
• W4306755639 cites W2109342913 @default.
• W4306755639 cites W2110218889 @default.
• W4306755639 cites W2112364185 @default.
• W4306755639 cites W2118664783 @default.
• W4306755639 cites W2122673596 @default.
• W4306755639 cites W2136637914 @default.
• W4306755639 cites W2137015675 @default.
• W4306755639 cites W2138178197 @default.
• W4306755639 cites W2138811562 @default.
• W4306755639 cites W2140106443 @default.
• W4306755639 cites W2141052558 @default.
• W4306755639 cites W2144775551 @default.
• W4306755639 cites W2150418059 @default.
• W4306755639 cites W2155986121 @default.
• W4306755639 cites W2157025252 @default.
• W4306755639 cites W2164513795 @default.
• W4306755639 cites W2178047016 @default.
• W4306755639 cites W2180695509 @default.
• W4306755639 cites W2268343948 @default.
• W4306755639 cites W2300239046 @default.
• W4306755639 cites W2311203695 @default.
• W4306755639 cites W2318252144 @default.
• W4306755639 cites W2342819947 @default.
• W4306755639 cites W2399133269 @default.
• W4306755639 cites W2412724793 @default.
• W4306755639 cites W2415928627 @default.
• W4306755639 cites W2524123157 @default.
• W4306755639 cites W2597506409 @default.
• W4306755639 cites W2621632370 @default.
• W4306755639 cites W2766078585 @default.
• W4306755639 cites W2795977468 @default.
• W4306755639 cites W2800761154 @default.
• W4306755639 cites W2883838322 @default.
• W4306755639 cites W2885492560 @default.
• W4306755639 cites W2894404233 @default.
• W4306755639 cites W2896552542 @default.
• W4306755639 cites W2901864511 @default.
• W4306755639 cites W2912981349 @default.
• W4306755639 cites W2918486137 @default.
• W4306755639 cites W2937378659 @default.
• W4306755639 cites W2940809452 @default.
• W4306755639 cites W2944261658 @default.
• W4306755639 cites W2949848068 @default.
• W4306755639 cites W2950058687 @default.
• W4306755639 cites W2955977204 @default.
• W4306755639 cites W2956028194 @default.
• W4306755639 cites W2975983989 @default.
• W4306755639 cites W2977796271 @default.
• W4306755639 cites W2982531601 @default.
• W4306755639 cites W2999170785 @default.
• W4306755639 cites W3004220171 @default.
• W4306755639 cites W3034227283 @default.
• W4306755639 cites W3042408010 @default.
• W4306755639 cites W3045632094 @default.
• W4306755639 cites W3088602524 @default.
• W4306755639 cites W3113401927 @default.
• W4306755639 cites W3153428831 @default.
• W4306755639 cites W3161540023 @default.
• W4306755639 cites W3164587385 @default.
• W4306755639 cites W3170689505 @default.
• W4306755639 cites W3180924427 @default.
• W4306755639 cites W3210676561 @default.
• W4306755639 cites W34932482 @default.
• W4306755639 cites W4200248649 @default.
• W4306755639 cites W4212994002 @default.
• W4306755639 cites W4220710266 @default.
• W4306755639 cites W4242318543 @default.
• W4306755639 cites W4286761963 @default.
• W4306755639 doi "https://doi.org/10.3389/fmicb.2022.983083" @default.
• W4306755639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36338064" @default.
• W4306755639 hasPublicationYear "2022" @default.
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