FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306756176> ?p ?o ?g. }

• W4306756176 endingPage "1867" @default.
• W4306756176 startingPage "1849" @default.
• W4306756176 abstract "Previously, we reported that the mediation of Newcastle disease virus (NDV) pathogenicity by the 524YLMY527 motif depends mainly on the regulation of F protein transport to the cell surface. The virus and host determinants that govern this intracellular trafficking remain unknown. Here, we confirmed that host adaptor protein (AP) complexes are involved in NDV infection using small interfering RNA. The transport of viral F protein to the cell surface depends on host transport proteins. We observed that the trends for host expression of AP complexes AP1M1 and AP2M1 were similar to those of mutated F proteins, especially in the membrane protein. NDV F protein interacted with AP1M1 and AP2M1, and the YLMY motif influenced this interaction. Knockdown of AP1M1 or AP2M1 suppressed the intracellular and extracellular virus titre of mutated-YLMY-motif NDVs, especially rSG10*-F/Y527A and rSG10*-F/Y524AY527A, to varying degrees. Therefore, the YLMY motif regulates AP-mediated viral F protein transportation from the cytoplasm to the cell surface and subsequently affects viral titer. We further found that the YLMY-motif mutants were differently associated with the process of AAK1 and GAK kinase-mediated AP – viral F protein interaction. These data demonstrate that the essential YLMY motif located in the NDV F protein cytoplasmic tail recruits AP to direct the F protein to the cell surface, which is necessary for its ability to affect virus budding. This study provides support for a deeper understanding of virus and host determinants that facilitate virus trafficking, which can be exploited in the design of novel antiviral therapies." @default.
• W4306756176 created "2022-10-19" @default.
• W4306756176 creator A5004405673 @default.
• W4306756176 creator A5009824578 @default.
• W4306756176 creator A5014345513 @default.
• W4306756176 creator A5016058045 @default.
• W4306756176 creator A5035339773 @default.
• W4306756176 creator A5036536186 @default.
• W4306756176 creator A5039070544 @default.
• W4306756176 creator A5040377676 @default.
• W4306756176 creator A5045571437 @default.
• W4306756176 creator A5064923831 @default.
• W4306756176 creator A5070106472 @default.
• W4306756176 date "2022-10-18" @default.
• W4306756176 modified "2023-09-26" @default.
• W4306756176 title "Adaptor complex-mediated trafficking of Newcastle disease virus fusion protein is regulated by the YLMY motif of its cytoplasmic tail" @default.
• W4306756176 cites W1670582766 @default.
• W4306756176 cites W1826847771 @default.
• W4306756176 cites W1967993418 @default.
• W4306756176 cites W1968971638 @default.
• W4306756176 cites W1995191281 @default.
• W4306756176 cites W1995355944 @default.
• W4306756176 cites W2000295298 @default.
• W4306756176 cites W2010841341 @default.
• W4306756176 cites W2023404116 @default.
• W4306756176 cites W2025022118 @default.
• W4306756176 cites W2031117374 @default.
• W4306756176 cites W2037203429 @default.
• W4306756176 cites W2045437791 @default.
• W4306756176 cites W2056379037 @default.
• W4306756176 cites W2062299478 @default.
• W4306756176 cites W2062660708 @default.
• W4306756176 cites W2062819360 @default.
• W4306756176 cites W2071172219 @default.
• W4306756176 cites W2072328988 @default.
• W4306756176 cites W2079232939 @default.
• W4306756176 cites W2081937823 @default.
• W4306756176 cites W2084460699 @default.
• W4306756176 cites W2085672090 @default.
• W4306756176 cites W2086999574 @default.
• W4306756176 cites W2104332066 @default.
• W4306756176 cites W2107627347 @default.
• W4306756176 cites W2112292369 @default.
• W4306756176 cites W2116550356 @default.
• W4306756176 cites W2126241449 @default.
• W4306756176 cites W2126404587 @default.
• W4306756176 cites W2126604662 @default.
• W4306756176 cites W2128421923 @default.
• W4306756176 cites W2130301047 @default.
• W4306756176 cites W2134959285 @default.
• W4306756176 cites W2143935409 @default.
• W4306756176 cites W2148351021 @default.
• W4306756176 cites W2148463680 @default.
• W4306756176 cites W2149814335 @default.
• W4306756176 cites W2156010727 @default.
• W4306756176 cites W2156802919 @default.
• W4306756176 cites W2158907019 @default.
• W4306756176 cites W2168343203 @default.
• W4306756176 cites W2169386721 @default.
• W4306756176 cites W2779334959 @default.
• W4306756176 cites W2783137619 @default.
• W4306756176 cites W2785331269 @default.
• W4306756176 cites W2803476990 @default.
• W4306756176 cites W2915543899 @default.
• W4306756176 cites W2947572658 @default.
• W4306756176 cites W2948932435 @default.
• W4306756176 cites W2982509872 @default.
• W4306756176 cites W3025149794 @default.
• W4306756176 cites W3037312024 @default.
• W4306756176 cites W3049406855 @default.
• W4306756176 cites W3131428991 @default.
• W4306756176 cites W3145225918 @default.
• W4306756176 cites W4200600086 @default.
• W4306756176 doi "https://doi.org/10.1080/21505594.2022.2136433" @default.
• W4306756176 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36258290" @default.
• W4306756176 hasPublicationYear "2022" @default.
• W4306756176 type Work @default.
• W4306756176 citedByCount "1" @default.
• W4306756176 countsByYear W43067561762023 @default.
• W4306756176 crossrefType "journal-article" @default.
• W4306756176 hasAuthorship W4306756176A5004405673 @default.
• W4306756176 hasAuthorship W4306756176A5009824578 @default.
• W4306756176 hasAuthorship W4306756176A5014345513 @default.
• W4306756176 hasAuthorship W4306756176A5016058045 @default.
• W4306756176 hasAuthorship W4306756176A5035339773 @default.
• W4306756176 hasAuthorship W4306756176A5036536186 @default.
• W4306756176 hasAuthorship W4306756176A5039070544 @default.
• W4306756176 hasAuthorship W4306756176A5040377676 @default.
• W4306756176 hasAuthorship W4306756176A5045571437 @default.
• W4306756176 hasAuthorship W4306756176A5064923831 @default.
• W4306756176 hasAuthorship W4306756176A5070106472 @default.
• W4306756176 hasBestOaLocation W43067561761 @default.
• W4306756176 hasConcept C140704245 @default.
• W4306756176 hasConcept C1491633281 @default.
• W4306756176 hasConcept C159047783 @default.
• W4306756176 hasConcept C173396325 @default.
• W4306756176 hasConcept C183786373 @default.
• W4306756176 hasConcept C190062978 @default.

• next