FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306756872> ?p ?o ?g. }

• W4306756872 endingPage "55" @default.
• W4306756872 startingPage "47" @default.
• W4306756872 abstract "Choline has been shown to exert atherogenic effects in Apoe-/- and Ldlr-/- mice, related to its conversion by gut bacteria into trimethylamine (TMA) that is converted by the liver into the proinflammatory metabolite trimethylamine-N-oxide (TMAO). Since butyrate beneficially modulates the gut microbiota and has anti-inflammatory and antiatherogenic properties, the aim of the present study was to investigate whether butyrate can alleviate choline-induced atherosclerosis. To this end, we used APOE*3-Leiden.CETP mice, a well-established atherosclerosis-prone model with human-like lipoprotein metabolism.Female APOE*3-Leiden.CETP mice were fed an atherogenic diet alone or supplemented with choline, butyrate or their combination for 16 weeks.Interestingly, choline protected against fat mass gain, increased the abundance of anti-inflammatory gut microbes, and increased the expression of gut microbial genes involved in TMA and TMAO degradation. Butyrate similarly attenuated fat mass gain and beneficially modulated the gut microbiome, as shown by increased abundance of anti-inflammatory and short chain fatty acid-producing microbes, and inhibited expression of gut microbial genes involved in lipopolysaccharide synthesis. Both choline and butyrate upregulated hepatic expression of flavin-containing monooxygenases, and their combination resulted in highest circulating TMAO levels. Nonetheless, choline, butyrate and their combination did not influence atherosclerosis development, and TMAO levels were not associated with atherosclerotic lesion size.While choline and butyrate have been reported to oppositely modulate atherosclerosis development in Apoe-/- and Ldlr-/- mice as related to changes in the gut microbiota, both dietary constituents did not affect atherosclerosis development while beneficially modulating the gut microbiome in APOE*3-Leiden.CETP mice." @default.
• W4306756872 created "2022-10-19" @default.
• W4306756872 creator A5009590736 @default.
• W4306756872 creator A5016373252 @default.
• W4306756872 creator A5023486589 @default.
• W4306756872 creator A5045353918 @default.
• W4306756872 creator A5047839791 @default.
• W4306756872 creator A5055222643 @default.
• W4306756872 creator A5058442779 @default.
• W4306756872 creator A5060123483 @default.
• W4306756872 creator A5067093084 @default.
• W4306756872 date "2022-12-01" @default.
• W4306756872 modified "2023-09-25" @default.
• W4306756872 title "Choline and butyrate beneficially modulate the gut microbiome without affecting atherosclerosis in APOE*3-Leiden.CETP mice" @default.
• W4306756872 cites W1990896493 @default.
• W4306756872 cites W2003342633 @default.
• W4306756872 cites W2032149290 @default.
• W4306756872 cites W2035588804 @default.
• W4306756872 cites W2073208648 @default.
• W4306756872 cites W2078599166 @default.
• W4306756872 cites W2081275026 @default.
• W4306756872 cites W2101209169 @default.
• W4306756872 cites W2115944543 @default.
• W4306756872 cites W2118882750 @default.
• W4306756872 cites W2132328792 @default.
• W4306756872 cites W2150644041 @default.
• W4306756872 cites W2162078360 @default.
• W4306756872 cites W2162601736 @default.
• W4306756872 cites W2166691283 @default.
• W4306756872 cites W2201540420 @default.
• W4306756872 cites W2211097356 @default.
• W4306756872 cites W2211887163 @default.
• W4306756872 cites W2288501492 @default.
• W4306756872 cites W2346256160 @default.
• W4306756872 cites W2559332652 @default.
• W4306756872 cites W2599061839 @default.
• W4306756872 cites W2726613625 @default.
• W4306756872 cites W2765733390 @default.
• W4306756872 cites W2789891739 @default.
• W4306756872 cites W2897063882 @default.
• W4306756872 cites W2898905022 @default.
• W4306756872 cites W2899697084 @default.
• W4306756872 cites W2899852374 @default.
• W4306756872 cites W2920558304 @default.
• W4306756872 cites W2939052468 @default.
• W4306756872 cites W2990509155 @default.
• W4306756872 cites W3009498704 @default.
• W4306756872 cites W3047287983 @default.
• W4306756872 cites W3049052172 @default.
• W4306756872 cites W3095781004 @default.
• W4306756872 cites W3107083588 @default.
• W4306756872 cites W3135668090 @default.
• W4306756872 cites W3200935965 @default.
• W4306756872 cites W3206369475 @default.
• W4306756872 cites W3207692850 @default.
• W4306756872 cites W4213378213 @default.
• W4306756872 cites W4220702962 @default.
• W4306756872 cites W4220758943 @default.
• W4306756872 cites W4224277413 @default.
• W4306756872 cites W4226070022 @default.
• W4306756872 doi "https://doi.org/10.1016/j.atherosclerosis.2022.10.009" @default.
• W4306756872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36347649" @default.
• W4306756872 hasPublicationYear "2022" @default.
• W4306756872 type Work @default.
• W4306756872 citedByCount "2" @default.
• W4306756872 countsByYear W43067568722023 @default.
• W4306756872 crossrefType "journal-article" @default.
• W4306756872 hasAuthorship W4306756872A5009590736 @default.
• W4306756872 hasAuthorship W4306756872A5016373252 @default.
• W4306756872 hasAuthorship W4306756872A5023486589 @default.
• W4306756872 hasAuthorship W4306756872A5045353918 @default.
• W4306756872 hasAuthorship W4306756872A5047839791 @default.
• W4306756872 hasAuthorship W4306756872A5055222643 @default.
• W4306756872 hasAuthorship W4306756872A5058442779 @default.
• W4306756872 hasAuthorship W4306756872A5060123483 @default.
• W4306756872 hasAuthorship W4306756872A5067093084 @default.
• W4306756872 hasBestOaLocation W43067568721 @default.
• W4306756872 hasConcept C100544194 @default.
• W4306756872 hasConcept C126322002 @default.
• W4306756872 hasConcept C134018914 @default.
• W4306756872 hasConcept C185592680 @default.
• W4306756872 hasConcept C2776149385 @default.
• W4306756872 hasConcept C2776979534 @default.
• W4306756872 hasConcept C2780924926 @default.
• W4306756872 hasConcept C2781123555 @default.
• W4306756872 hasConcept C539455810 @default.
• W4306756872 hasConcept C55493867 @default.
• W4306756872 hasConcept C71924100 @default.
• W4306756872 hasConcept C86803240 @default.
• W4306756872 hasConceptScore W4306756872C100544194 @default.
• W4306756872 hasConceptScore W4306756872C126322002 @default.
• W4306756872 hasConceptScore W4306756872C134018914 @default.
• W4306756872 hasConceptScore W4306756872C185592680 @default.
• W4306756872 hasConceptScore W4306756872C2776149385 @default.
• W4306756872 hasConceptScore W4306756872C2776979534 @default.
• W4306756872 hasConceptScore W4306756872C2780924926 @default.
• W4306756872 hasConceptScore W4306756872C2781123555 @default.
• W4306756872 hasConceptScore W4306756872C539455810 @default.

• next