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- W4306758897 abstract "Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines ALS using published data (3, 4). We found significant differential expression of BCAT1, encoding branched-chain amino acid transaminase 1, in the iPSC-derived motor neurons of patients with ALS. BCAT1 was also differentially expressed in the skeletal muscle of patients with ALS. BCAT1 transcript was present at significantly higher levels in ALS patient motor neurons as compared to control motor neurons. These analyses will begin to define the transcriptional landscape of ALS." @default.
- W4306758897 created "2022-10-19" @default.
- W4306758897 creator A5024900493 @default.
- W4306758897 date "2022-10-17" @default.
- W4306758897 modified "2023-09-25" @default.
- W4306758897 title "Differential expression of BCAT1 in amyotrophic lateral sclerosis." @default.
- W4306758897 doi "https://doi.org/10.31219/osf.io/wsbev" @default.
- W4306758897 hasPublicationYear "2022" @default.
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