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• W4306761508 endingPage "102618" @default.
• W4306761508 startingPage "102618" @default.
• W4306761508 abstract "Ferroptosis plays an important role in ischemia-reperfusion (I/R)-induced cardiac injury and there are many defects in current targeted delivery of miRNAs for the treatment of ferroptosis. We herein report a unique hydrogel (Gel) that can be triggered by a near-infrared-II (NIR-II) light with deep tissue penetration and biocompatible maximum permissible exposure (MPE) value for in situ treatment after I/R. The mir-196c-3p mimic (mimics) and photothermal nanoparticles (BTN) were co-encapsulated in an injectable Gel (mimics + Gel/BTN) with NIR-II light-triggered release. Using 1064 nm light irradiation, local microenvironment photothermal-triggered on-demand noninvasive controllable delivery of miRNA was achieved, aiming to inhibit I/R-induced ferroptosis. Consequently, declined ferroptosis in cardiomyocytes and improved cardiac function, survival rate in rats was achieved through the controlled release of Gel/BTN mimics in I/R model to simultaneously inhibit ferroptosis hub genes NOX4, P53, and LOX expression." @default.
• W4306761508 created "2022-10-19" @default.
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• W4306761508 date "2023-01-01" @default.
• W4306761508 modified "2023-10-16" @default.
• W4306761508 title "Delivery of Mir-196c-3p with NIR-II light-triggered gel attenuates cardiomyocyte ferroptosis in cardiac ischemia-reperfusion injury" @default.
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• W4306761508 doi "https://doi.org/10.1016/j.nano.2022.102618" @default.
• W4306761508 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36270453" @default.
• W4306761508 hasPublicationYear "2023" @default.
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