Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306762009> ?p ?o ?g. }
- W4306762009 endingPage "6954" @default.
- W4306762009 startingPage "6954" @default.
- W4306762009 abstract "Salix pseudolasiogyne (Salicaceae), the weeping willow, has been used in traditional Korean medicine to treat pain and fever due to its high concentrations of salicylic acid and salicin. The present study investigated bioactive compounds from S. pseudolasiogyne twigs to discover bioactive natural products. Phytochemical investigation of the ethanol (EtOH) extract of S. pseudolasiogyne twigs followed by liquid chromatography-mass spectrometry (LC/MS)-based analysis led to the isolation of two salicin derivatives, salicortinol and salicortin, the structures of which were determined by interpretation of their NMR spectra and data from the LC/MS analysis. To the best of our knowledge, this is the first report of salicortinol isolated from S. pseudolasiogyne. The isolated compounds were evaluated for their anti-adipogenic effects in 3T3-L1 cells. Both salicortinol and salicortin were found to significantly inhibit adipocyte differentiation in 3T3-L1 cells. In particular, salicortin exhibited a strong inhibitory effect on lipid accumulation. Furthermore, salicortin inhibited the expression of lipogenic and adipogenic transcription factors, including FASN, FABP4, C/EBPα, C/EBPβ, and PPARγ, without inducing cytotoxicity. These results suggest that salicortin could be a potential therapeutic compound for the prevention or treatment of metabolic disorders such as obesity." @default.
- W4306762009 created "2022-10-19" @default.
- W4306762009 creator A5006513443 @default.
- W4306762009 creator A5028092876 @default.
- W4306762009 creator A5052359563 @default.
- W4306762009 creator A5052473615 @default.
- W4306762009 creator A5065014512 @default.
- W4306762009 creator A5068809615 @default.
- W4306762009 creator A5073559410 @default.
- W4306762009 creator A5089297064 @default.
- W4306762009 date "2022-10-17" @default.
- W4306762009 modified "2023-10-14" @default.
- W4306762009 title "Anti-Adipogenic Effects of Salicortin from the Twigs of Weeping Willow (Salix pseudolasiogyne) in 3T3-L1 Cells" @default.
- W4306762009 cites W1977586086 @default.
- W4306762009 cites W1983757151 @default.
- W4306762009 cites W1985663890 @default.
- W4306762009 cites W1989020172 @default.
- W4306762009 cites W1990497150 @default.
- W4306762009 cites W2012989172 @default.
- W4306762009 cites W2023817666 @default.
- W4306762009 cites W2052045899 @default.
- W4306762009 cites W2055193768 @default.
- W4306762009 cites W2059992589 @default.
- W4306762009 cites W2083561803 @default.
- W4306762009 cites W2085957571 @default.
- W4306762009 cites W2105470546 @default.
- W4306762009 cites W2137668368 @default.
- W4306762009 cites W2140315299 @default.
- W4306762009 cites W2167853232 @default.
- W4306762009 cites W2284659436 @default.
- W4306762009 cites W2312885017 @default.
- W4306762009 cites W2396735978 @default.
- W4306762009 cites W2405624971 @default.
- W4306762009 cites W2522814719 @default.
- W4306762009 cites W2615708622 @default.
- W4306762009 cites W2625225193 @default.
- W4306762009 cites W2790340959 @default.
- W4306762009 cites W2902747790 @default.
- W4306762009 cites W2921972886 @default.
- W4306762009 cites W2924199431 @default.
- W4306762009 cites W2983689600 @default.
- W4306762009 cites W3003819542 @default.
- W4306762009 cites W3041585215 @default.
- W4306762009 cites W3083799791 @default.
- W4306762009 cites W3144184416 @default.
- W4306762009 cites W3157405862 @default.
- W4306762009 cites W4200237735 @default.
- W4306762009 doi "https://doi.org/10.3390/molecules27206954" @default.
- W4306762009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36296558" @default.
- W4306762009 hasPublicationYear "2022" @default.
- W4306762009 type Work @default.
- W4306762009 citedByCount "2" @default.
- W4306762009 countsByYear W43067620092022 @default.
- W4306762009 countsByYear W43067620092023 @default.
- W4306762009 crossrefType "journal-article" @default.
- W4306762009 hasAuthorship W4306762009A5006513443 @default.
- W4306762009 hasAuthorship W4306762009A5028092876 @default.
- W4306762009 hasAuthorship W4306762009A5052359563 @default.
- W4306762009 hasAuthorship W4306762009A5052473615 @default.
- W4306762009 hasAuthorship W4306762009A5065014512 @default.
- W4306762009 hasAuthorship W4306762009A5068809615 @default.
- W4306762009 hasAuthorship W4306762009A5073559410 @default.
- W4306762009 hasAuthorship W4306762009A5089297064 @default.
- W4306762009 hasBestOaLocation W43067620091 @default.
- W4306762009 hasConcept C109316439 @default.
- W4306762009 hasConcept C122927707 @default.
- W4306762009 hasConcept C142536801 @default.
- W4306762009 hasConcept C185592680 @default.
- W4306762009 hasConcept C202751555 @default.
- W4306762009 hasConcept C2780220376 @default.
- W4306762009 hasConcept C55493867 @default.
- W4306762009 hasConceptScore W4306762009C109316439 @default.
- W4306762009 hasConceptScore W4306762009C122927707 @default.
- W4306762009 hasConceptScore W4306762009C142536801 @default.
- W4306762009 hasConceptScore W4306762009C185592680 @default.
- W4306762009 hasConceptScore W4306762009C202751555 @default.
- W4306762009 hasConceptScore W4306762009C2780220376 @default.
- W4306762009 hasConceptScore W4306762009C55493867 @default.
- W4306762009 hasFunder F4320322120 @default.
- W4306762009 hasIssue "20" @default.
- W4306762009 hasLocation W43067620091 @default.
- W4306762009 hasLocation W43067620092 @default.
- W4306762009 hasLocation W43067620093 @default.
- W4306762009 hasLocation W43067620094 @default.
- W4306762009 hasOpenAccess W4306762009 @default.
- W4306762009 hasPrimaryLocation W43067620091 @default.
- W4306762009 hasRelatedWork W1977136059 @default.
- W4306762009 hasRelatedWork W1995714647 @default.
- W4306762009 hasRelatedWork W2000224242 @default.
- W4306762009 hasRelatedWork W2007680694 @default.
- W4306762009 hasRelatedWork W2016298561 @default.
- W4306762009 hasRelatedWork W2082812932 @default.
- W4306762009 hasRelatedWork W2537626199 @default.
- W4306762009 hasRelatedWork W2604280754 @default.
- W4306762009 hasRelatedWork W3178353996 @default.
- W4306762009 hasRelatedWork W4225253141 @default.
- W4306762009 hasVolume "27" @default.
- W4306762009 isParatext "false" @default.