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- W4306762707 abstract "Ovarian cryopreservation and transplantation is a fertility preservation option, but a majority of follicles were lost due to grafting process. Accelerated activation of primordial follicle and follicle apoptosis are responsible for follicle depletion following grafting. Since apoptosis and autophagy share common upstream signals, and cell switches between apoptosis and autophagy, the aim of this study was to investigate whether autophagy took place in ovaries following transplantation. Transmission electron microscopy and immunofluorescence were used to detect autophagic changes in grafted mice ovaries. Results shown that autophagosomes increased rapidly at 2 days following ovarian transplantation in granulosa cells of growing follicles, and stromal cells. The study indicated that autophagy is actively involved during ovarian grafting. Manipulation of autophagy might provide another way to improve ovarian reserved during grafting." @default.
- W4306762707 created "2022-10-19" @default.
- W4306762707 creator A5079396137 @default.
- W4306762707 date "2023-01-01" @default.
- W4306762707 modified "2023-09-27" @default.
- W4306762707 title "Autophagy phenomenon in mice ovaries following transplantation" @default.
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- W4306762707 doi "https://doi.org/10.1016/j.theriogenology.2022.10.018" @default.
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