Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306765719> ?p ?o ?g. }
Showing items 1 to 44 of
44
with 100 items per page.
- W4306765719 abstract "The COVID-19 pandemic, caused by SARS-CoV-2, has infected more than 260 million people worldwide, causing more than 5.2 million deaths. Unlike other viral infections, COVID-19 is characterized by widespread and severe systemic effects, immune dysregulation, pneumonia, ARDS, and multiple organ damage. It also causes serious inflammatory, autoimmune, endocrine, and neuropsychiatric diseases also called post-COVID syndromes. This broad spectrum of disease seen in COVID-19 cannot be explained by the previously described mechanism of viral tropism based on a single receptor mediated by ACE2 and TMPRSS2 receptors. The pathogenesis of COVID-19 can only be explained by the influence of many receptors and signaling pathways. At a crossroads in retinol metabolism and multiple inflammation-related cellular signaling pathways, STRA6 plays a key role in the pathogenesis of COVID-19. Systemic organ involvement, neuroendocrine involvement, and immunological involvement in COVID-19 can be explained very clearly through STRA6 signaling. Retinoid metabolism and STRA6 activity interact. It has been previously shown that retinol levels are reduced in COVID-19. Due to retinol depletion in COVID-19, the functions of STRA6 are also impaired. This leads to the disruption of multiple cellular signaling pathways associated with inflammation. STRA6 has a key role in the regulation of inflammatory pathways and retinoid signaling in the pathogenesis of COVID-19 and is at the center of the inflammatory process in COVID-19 due to the multiple cellular signaling pathways it directs. Targeting STRA6 and its associated signaling pathways may yield result in the prevention and treatment of many inflammatory diseases as well as COVID-19." @default.
- W4306765719 created "2022-10-19" @default.
- W4306765719 creator A5011057254 @default.
- W4306765719 date "2022-10-18" @default.
- W4306765719 modified "2023-09-23" @default.
- W4306765719 title "STRA6: key to inflammatory pathways in COVID-19" @default.
- W4306765719 doi "https://doi.org/10.31219/osf.io/3xmyq" @default.
- W4306765719 hasPublicationYear "2022" @default.
- W4306765719 type Work @default.
- W4306765719 citedByCount "0" @default.
- W4306765719 crossrefType "posted-content" @default.
- W4306765719 hasAuthorship W4306765719A5011057254 @default.
- W4306765719 hasBestOaLocation W43067657192 @default.
- W4306765719 hasConcept C203014093 @default.
- W4306765719 hasConcept C2776914184 @default.
- W4306765719 hasConcept C2780942790 @default.
- W4306765719 hasConcept C62478195 @default.
- W4306765719 hasConcept C71924100 @default.
- W4306765719 hasConcept C86803240 @default.
- W4306765719 hasConcept C95444343 @default.
- W4306765719 hasConceptScore W4306765719C203014093 @default.
- W4306765719 hasConceptScore W4306765719C2776914184 @default.
- W4306765719 hasConceptScore W4306765719C2780942790 @default.
- W4306765719 hasConceptScore W4306765719C62478195 @default.
- W4306765719 hasConceptScore W4306765719C71924100 @default.
- W4306765719 hasConceptScore W4306765719C86803240 @default.
- W4306765719 hasConceptScore W4306765719C95444343 @default.
- W4306765719 hasLocation W43067657191 @default.
- W4306765719 hasLocation W43067657192 @default.
- W4306765719 hasOpenAccess W4306765719 @default.
- W4306765719 hasPrimaryLocation W43067657191 @default.
- W4306765719 hasRelatedWork W162192359 @default.
- W4306765719 hasRelatedWork W1987712008 @default.
- W4306765719 hasRelatedWork W2186316345 @default.
- W4306765719 hasRelatedWork W2313447129 @default.
- W4306765719 hasRelatedWork W2379289745 @default.
- W4306765719 hasRelatedWork W2895946319 @default.
- W4306765719 hasRelatedWork W2992443928 @default.
- W4306765719 hasRelatedWork W3032540778 @default.
- W4306765719 hasRelatedWork W4241335203 @default.
- W4306765719 hasRelatedWork W4248746885 @default.
- W4306765719 isParatext "false" @default.
- W4306765719 isRetracted "false" @default.
- W4306765719 workType "article" @default.