Matches in SemOpenAlex for { <https://semopenalex.org/work/W4306777802> ?p ?o ?g. }
- W4306777802 abstract "The late-stage site-selective derivatisation of peptides has many potential applications in structure-activity relationship studies and postsynthetic modification or conjugation of bioactive compounds. The development of orthogonal methods for C-H functionalisation is crucial for such peptide derivatisation. Among them, biocatalytic methods are increasingly attracting attention. Tryptophan halogenases emerged as valuable catalysts to functionalise tryptophan (Trp), while direct enzyme-catalysed halogenation of synthetic peptides is yet unprecedented. Here, it is reported that the Trp 6-halogenase Thal accepts a wide range of amides and peptides containing a Trp moiety. Increasing the sequence length and reaction optimisation made bromination of pentapeptides feasible with good turnovers and a broad sequence scope, while regioselectivity turned out to be sequence dependent. Comparison of X-ray single crystal structures of Thal in complex with d-Trp and a dipeptide revealed a significantly altered binding mode for the peptide. The viability of this bioorthogonal approach was exemplified by halogenation of a cyclic RGD peptide." @default.
- W4306777802 created "2022-10-19" @default.
- W4306777802 creator A5021947053 @default.
- W4306777802 creator A5024323932 @default.
- W4306777802 creator A5065841766 @default.
- W4306777802 creator A5066273209 @default.
- W4306777802 creator A5071609475 @default.
- W4306777802 creator A5073037544 @default.
- W4306777802 creator A5074716708 @default.
- W4306777802 creator A5078575294 @default.
- W4306777802 date "2022-11-23" @default.
- W4306777802 modified "2023-10-12" @default.
- W4306777802 title "Enzymatic Late‐Stage Halogenation of Peptides" @default.
- W4306777802 cites W1995666132 @default.
- W4306777802 cites W1997537633 @default.
- W4306777802 cites W2005425959 @default.
- W4306777802 cites W2006139806 @default.
- W4306777802 cites W2030557836 @default.
- W4306777802 cites W2041411283 @default.
- W4306777802 cites W2043825890 @default.
- W4306777802 cites W2046629336 @default.
- W4306777802 cites W2063097757 @default.
- W4306777802 cites W2065097700 @default.
- W4306777802 cites W2075034454 @default.
- W4306777802 cites W2098167941 @default.
- W4306777802 cites W2103968973 @default.
- W4306777802 cites W2109155760 @default.
- W4306777802 cites W2124026197 @default.
- W4306777802 cites W2126756093 @default.
- W4306777802 cites W2130038789 @default.
- W4306777802 cites W2134152126 @default.
- W4306777802 cites W2139205312 @default.
- W4306777802 cites W2141142472 @default.
- W4306777802 cites W2151709132 @default.
- W4306777802 cites W2151772329 @default.
- W4306777802 cites W2163341755 @default.
- W4306777802 cites W2163839853 @default.
- W4306777802 cites W2164203771 @default.
- W4306777802 cites W2210120548 @default.
- W4306777802 cites W2290712119 @default.
- W4306777802 cites W2332008572 @default.
- W4306777802 cites W2345761168 @default.
- W4306777802 cites W2418557497 @default.
- W4306777802 cites W2519175090 @default.
- W4306777802 cites W2520950625 @default.
- W4306777802 cites W2559872184 @default.
- W4306777802 cites W2563555446 @default.
- W4306777802 cites W2611252889 @default.
- W4306777802 cites W2735283338 @default.
- W4306777802 cites W2739637903 @default.
- W4306777802 cites W2744312350 @default.
- W4306777802 cites W2754675125 @default.
- W4306777802 cites W2789550049 @default.
- W4306777802 cites W2792184967 @default.
- W4306777802 cites W2800612869 @default.
- W4306777802 cites W2802923922 @default.
- W4306777802 cites W2811474915 @default.
- W4306777802 cites W2896706920 @default.
- W4306777802 cites W2903851210 @default.
- W4306777802 cites W2904581264 @default.
- W4306777802 cites W2914589620 @default.
- W4306777802 cites W2915681602 @default.
- W4306777802 cites W2962143688 @default.
- W4306777802 cites W2965302796 @default.
- W4306777802 cites W2971483975 @default.
- W4306777802 cites W2976485980 @default.
- W4306777802 cites W2979372408 @default.
- W4306777802 cites W2979824003 @default.
- W4306777802 cites W2981561997 @default.
- W4306777802 cites W2981797791 @default.
- W4306777802 cites W3124499690 @default.
- W4306777802 cites W3125924278 @default.
- W4306777802 cites W3134283679 @default.
- W4306777802 cites W3209896998 @default.
- W4306777802 cites W4211062751 @default.
- W4306777802 cites W4241391413 @default.
- W4306777802 cites W4244689731 @default.
- W4306777802 cites W4248872320 @default.
- W4306777802 cites W4283011713 @default.
- W4306777802 cites W4306777802 @default.
- W4306777802 doi "https://doi.org/10.1002/cbic.202200569" @default.
- W4306777802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36259362" @default.
- W4306777802 hasPublicationYear "2022" @default.
- W4306777802 type Work @default.
- W4306777802 citedByCount "4" @default.
- W4306777802 countsByYear W43067778022022 @default.
- W4306777802 countsByYear W43067778022023 @default.
- W4306777802 crossrefType "journal-article" @default.
- W4306777802 hasAuthorship W4306777802A5021947053 @default.
- W4306777802 hasAuthorship W4306777802A5024323932 @default.
- W4306777802 hasAuthorship W4306777802A5065841766 @default.
- W4306777802 hasAuthorship W4306777802A5066273209 @default.
- W4306777802 hasAuthorship W4306777802A5071609475 @default.
- W4306777802 hasAuthorship W4306777802A5073037544 @default.
- W4306777802 hasAuthorship W4306777802A5074716708 @default.
- W4306777802 hasAuthorship W4306777802A5078575294 @default.
- W4306777802 hasBestOaLocation W43067778021 @default.
- W4306777802 hasConcept C161790260 @default.
- W4306777802 hasConcept C178790620 @default.
- W4306777802 hasConcept C181199279 @default.