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- W4306784141 abstract "Antibody-mediated rejection (ABMR) is the major cause of chronic allograft dysfunction and loss in kidney transplantation. The immunological mechanisms of ABMR that have been featured in the latest studies indicate a highly complex interplay between various immune and nonimmune cell types. Clinical diagnostic standards have long been criticized for being arbitrary and the lack of accuracy. Transcriptomic approaches, including microarray and RNA sequencing of allograft biopsies, enable the identification of differential gene expression and the continuous improvement of diagnostics. Given that conventional bulk transcriptomic approaches only reflect the average gene expression but not the status at the single-cell level, thereby ignoring the heterogeneity of the transcriptome across individual cells, single-cell RNA sequencing is rising as a powerful tool to provide a high-resolution transcriptome map of immune cells, which allows the elucidation of the pathogenesis and may facilitate the development of novel strategies for clinical treatment of ABMR." @default.
- W4306784141 created "2022-10-19" @default.
- W4306784141 creator A5017237572 @default.
- W4306784141 date "2022-10-19" @default.
- W4306784141 modified "2023-09-24" @default.
- W4306784141 title "Applications of Transcriptomics in the Research of Antibody-Mediated Rejection in Kidney Transplantation: Progress and Perspectives" @default.
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- W4306784141 doi "https://doi.org/10.1080/15476278.2022.2131357" @default.
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- W4306784141 hasPublicationYear "2022" @default.
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